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Items where Author is "Leake, Professor David"

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Poston, R. N., Chughtai, J., Ujkaj, D., Louis, H., Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 and Cooper, D. (2022) Monocytic cell adhesion to oxidised ligands: relevance to cardiovascular disease. Biomedicines, 10 (12). 3083. ISSN 2227-9059 doi: https://doi.org/10.3390/biomedicines10123083

Ojo, O. O. and Leake, D. ORCID: https://orcid.org/0000-0002-1742-6134 (2022) Effects of lysosomal low density lipoprotein oxidation by ferritin on macrophage function. Free Radical Research. GFRR-OM-2022-0211. ISSN 1071-5762 doi: https://doi.org/10.1080/10715762.2022.2133703

Ahmad, F., Mitchell, R., Houben, T., Palo, A., Yasdati, T., Parnell, A., Patel, K., Shiri-Sverdlov, R. and Leake, D. ORCID: https://orcid.org/0000-0002-1742-6134 (2021) Cysteamine decreases low density lipoprotein oxidation, causes regression of atherosclerosis and improves liver and muscle function in LDL receptor deficient mice. JAHA: Journal of the American Heart Association, 10 (18). ISSN 2047-9980 doi: https://doi.org/10.1161/JAHA.120.017524

Houben, T., Yadati, T., De Kruijf, R., Gijbels, M. J., Luiken, J., Van Zandvoort, M., Kapsokalyvas, D., Lütjohann, D., Westerterp, M., Plat, J., Leake, D. ORCID: https://orcid.org/0000-0002-1742-6134 and Shiri-Sverdlov, R. (2021) Pro-inflammatory implications of 2-hydroxypropyl-β-cyclodextrin treatment. Frontiers in Immunology, 12. 716357. ISSN 1664-3224 doi: https://doi.org/10.3389/fimmu.2021.716357

Ojo, O. O. and Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 (2021) Vitamins E and C do not effectively inhibit low density lipoprotein oxidation by ferritin at lysosomal pH. Free Radical Research, 55 (5). pp. 525-534. ISSN 1071-5762 doi: https://doi.org/10.1080/10715762.2021.1964494

Alboaklah, H. K.M. and Leake, D. ORCID: https://orcid.org/0000-0002-1742-6134 (2020) Effect of vitamin E on low density lipoprotein oxidation at lysosomal pH. Free Radical Research, 54 (8-9). pp. 574-584. ISSN 1071-5762 doi: https://doi.org/10.1080/10715762.2020.1817912

Bhatti, S. N., Leidi, A., Leake, D. ORCID: https://orcid.org/0000-0002-1742-6134 and Li, J.-m. ORCID: https://orcid.org/0000-0002-3294-3818 (2020) Studying biological science does not lead to adoption of a healthy lifestyle. Perspectives in Public Health, 140 (4). pp. 232-239. ISSN 1757-9139 doi: https://doi.org/10.1177/1757913919890889

Wen, Y., Ahmad, F., Mohri, Z., Weinberg, P. D. and Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 (2019) Cysteamine inhibits lysosomal oxidation of low density lipoprotein in human macrophages and reduces atherosclerosis in mice. Atherosclerosis, 291. pp. 9-18. ISSN 0021-9150 doi: https://doi.org/10.1016/j.atherosclerosis.2019.09.019

Ahmad, F. and Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 (2019) Lysosomal oxidation of LDL alters lysosomal pH, induces senescence and increases secretion of pro-inflammatory cytokines in human macrophages. Journal of Lipid Research, 60. pp. 98-110. ISSN 1539-7262 doi: https://doi.org/10.1194/jlr.M088245

Ojo, O. O. and Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 (2018) Low density lipoprotein oxidation by ferritin at lysosomal pH. Chemistry and Physics of Lipids, 217. pp. 51-57. ISSN 0009-3084 doi: https://doi.org/10.1016/j.chemphyslip.2018.09.016

Palmer, C., Peri, F., Neumann, F., Ahmad, F., Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 and Pirianov, G. (2018) The synthetic glycolipid-based TLR4 antagonist FP7 negatively regulates in vitro and in vivo haematopoietic and non-haematopoietic vascular TLR4 signalling. Innate Immunity, 24 (7). pp. 411-421. ISSN 1753-4267 doi: https://doi.org/10.1177/1753425918798904

Ahmad, F. and Leake, D. ORCID: https://orcid.org/0000-0002-1742-6134 (2018) Antioxidants inhibit low density lipoprotein oxidation less at lysosomal pH: a possible explanation as to why the clinical trials of antioxidants might have failed. Chemistry and Physics of Lipids, 213. pp. 13-24. ISSN 0009-3084 doi: https://doi.org/10.1016/j.chemphyslip.2018.03.001

Calabuig-Navarro, M. V., Jackson, K. G. ORCID: https://orcid.org/0000-0002-0070-3203, Kemp, C. F., Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134, Walden, C. M., Lovegrove, J. A. ORCID: https://orcid.org/0000-0001-7633-9455 and Minihane, A. M. (2017) A randomized trial and novel SPR technique identifies altered lipoprotein-LDL receptor binding as a mechanism underlying elevated LDL-cholesterol in APOE4s. Scientific Reports, 7. 44119. ISSN 2045-2322 doi: https://doi.org/10.1038/srep44119

Gerry, A. B. and Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 (2014) Effect of low extracellular pH on NF-κB activation in macrophages. Atherosclerosis, 233 (2). pp. 537-544. ISSN 0021-9150 doi: https://doi.org/10.1016/j.atherosclerosis.2014.01.014

Wraith, K. S., Magwenzi, S., Aburima, A., Wen, Y., Leake, D. ORCID: https://orcid.org/0000-0002-1742-6134 and Naseem, K. M. (2013) Oxidised low-density lipoproteins induce rapid platelet activation and shape change through tyrosine kinase and Rho kinase-signaling pathways. Blood, 122 (4). pp. 580-589. ISSN 0006-4971 doi: https://doi.org/10.1182/blood-2013-04-491688

Satchell, L. and Leake, D. ORCID: https://orcid.org/0000-0002-1742-6134 (2012) Oxidation of low density lipoprotein by iron at lysosomal pH: implications for atherosclerosis. Biochemistry, 51 (18). pp. 3767-3775. ISSN 0006-2960 doi: https://doi.org/10.1021/bi2017975

Gieseg, S. P., Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134, Flavall, E. M., Amit, Z., Reid, L. and Yang, Y. T. (2009) Macrophage antioxidant protection within atherosclerotic plaques. Frontiers in Bioscience, 1 (14). pp. 1230-1246. ISSN 1093-9946 doi: https://doi.org/10.2741/3305

Gomez-Ruiz, J. A., Ames, J. M. and Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 (2008) Antioxidant activity and protective effects of green and dark coffee components against human low density lipoprotein oxidation. European Food Research and Technology, 227 (4). pp. 1017-1024. ISSN 1438-2377 doi: https://doi.org/10.1007/s00217-007-0815-5

Gerry, A. B. and Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 (2008) A moderate reduction in extracellular pH protects macrophages against apoptosis induced by oxidised low density lipoprotein. Journal of Lipid Research, 49 (4). pp. 782-789. ISSN 1539-7262 doi: https://doi.org/10.1194/jlr.M700349-JLR200

Gerry, A. B., Satchell, L. and Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 (2008) A novel method for production of lipid hydroperoxide- or oxysterol-rich low-density lipoprotein. Atherosclerosis, 197 (2). pp. 579-587. ISSN 0021-9150 doi: https://doi.org/10.1016/j.atherosclerosis.2007.08.026

Kappler, M., Gerry, A. B., Brown, E., Reid, L., Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 and Gieseg, S. P. (2007) Aqueous peroxyl radical exposure to THP-1 cells causes glutathione loss followed by protein oxidation and cell death without increased caspase-3 activity. Biochimica Et Biophysica Acta-Molecular Cell Research, 1773 (6). pp. 945-953. ISSN 0167-4889 doi: https://doi.org/10.1016/j.bbamcr.2007.04.001

Wong, W. M. R., Gerry, A. B., Putt, W., Roberts, J. L., Weinberg, R. B., Humphries, S. E., Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 and Talmud, P. J. (2007) Common variants of apolipoprotein A-IV differ in their ability to inhibit low density lipoprotein oxidation. Atherosclerosis, 192 (2). pp. 266-274. ISSN 0021-9150 doi: https://doi.org/10.1016/j.atherosclerosis.2006.07.017

Gomez-Ruiz, J. A., Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 and Ames, J. M. (2007) In vitro antioxidant activity of coffee compounds and their metabolites. Journal of Agricultural and Food Chemistry, 55 (17). pp. 6962-6969. ISSN 0021-8561 doi: https://doi.org/10.1021/jf0710985

Wen, Y. and Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 (2007) Low density lipoprotein undergoes oxidation within lysosomes in cells. Circulation Research, 100. pp. 1337-1343. ISSN 0009-7330 doi: https://doi.org/10.1161/CIRCRESAHA.107.151704

Wen, Y. C. and Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 (2007) Low density lipoprotein undergoes oxidation within lysosomes in cells. Circulation Research, 100 (9). pp. 1337-1343. ISSN 0009-7330 doi: https://doi.org/10.1161/circresaha.107.151704

Horsley, E. T. M., Burkitt, M. J., Jones, C. M. ORCID: https://orcid.org/0000-0001-7537-1509, Patterson, R. A., Harris, L. K., Moss, N. J., del Rio, J. D. and Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 (2007) Mechanism of the antioxidant to pro-oxidant switch in the behavior of dehydroascorbate during LDL oxidation by copper(II) ions. Archives of Biochemistry and Biophysics, 465 (2). pp. 303-314. ISSN 0003-9861 doi: https://doi.org/10.1016/j.abb.2007.07.005

Harris, L. K., Mann, G. E., Ruiz, E., Mushtaq, S. and Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 (2006) Ascorbate does not protect macrophages against apoptosis induced by oxidised low density lipoprotein. Archives of Biochemistry and Biophysics, 455 (1). pp. 68-76. ISSN 0003-9861 doi: https://doi.org/10.1016/j.abb.2006.07.019

Tricon, S., Burdge, G.C., Jones, E.L., Russell, J.J., El-Khazen, S., Moretti, E., Hall, W.L., Gerry, A.B., Leake, D.S. ORCID: https://orcid.org/0000-0002-1742-6134, Grimble, R.F., Williams, C.M., Calder, P.C. and Yaqoob, P. ORCID: https://orcid.org/0000-0002-6716-7599 (2006) Effects of dairy products naturally enriched with cis-9,trans-11 conjugated linoleic acid on the blood lipid profile in healthy middle-aged men. American Journal of Clinical Nutrition, 83 (4). pp. 744-753. ISSN 0002-9165

Jackson, K.G. ORCID: https://orcid.org/0000-0002-0070-3203, Maitin, V., Leake, D.S. ORCID: https://orcid.org/0000-0002-1742-6134, Yaqoob, P. ORCID: https://orcid.org/0000-0002-6716-7599 and Williams, C.M. (2006) Saturated fat-induced changes in S-f 60-400 particle composition reduces uptake of LDL by HepG2 cells. Journal of Lipid Research, 47 (2). pp. 393-403. ISSN 0022-2275 doi: https://doi.org/10.1194/jlr.M500382-JLR200

Anwar, A. A., Li, F. Y. L., Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134, Ishii, T., Mann, G. E. and Siow, R. C. M. (2005) Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: role of mitogen-activated protein kinases and Nrf2. Free Radical Biology and Medicine, 39 (2). pp. 227-236. ISSN 0891-5849 doi: https://doi.org/10.1016/j.freeradbiomed.2005.03.012

Anwar, A. A., Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 and Siow, R. C. M. (2004) MAPK pathways mediate induction of heme oxygenase-1 and glutathione by moderately oxidized low density lipoproteins in vascular smooth muscle cells. Free Radical Biology and Medicine, 36. S44-S44. ISSN 0891-5849

Ishii, T., Itoh, K., Ruiz, E., Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134, Unoki, H., Yamamoto, M. and Mann, G. E. (2004) Role of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages - Activation by oxidatively modified LDL and 4-hydroxynonenal. Circulation Research, 94 (5). pp. 609-616. ISSN 0009-7330 doi: https://doi.org/10.1161/01.res.0000119171.44657.45

Kavanagh, I.C., Symes, C.E., Renaudin, P., Nova, E., Mesa, M.D., Boukouvalas, G., Leake, D.S. ORCID: https://orcid.org/0000-0002-1742-6134 and Yaqoob, P. ORCID: https://orcid.org/0000-0002-6716-7599 (2003) Degree of oxidation of low density lipoprotein affects expression of CD36 and PPAR gamma, but not cytokine production, by human monocyte-macrophages. Atherosclerosis, 168 (2). pp. 271-282. ISSN 0021-9150 doi: https://doi.org/10.1016/s0021-9150(03)00148-5

Patterson, R. A., Lamb, D. J. and Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 (2003) Mechanisms by which cysteine can inhibit or promote the oxidation of low density lipoprotein by copper. Atherosclerosis, 169 (1). pp. 87-94. ISSN 0021-9150 doi: https://doi.org/10.1016/s0021-9150(03)00154-0

Talbot, R. M., del Rio, J. D., Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 and Weinberg, P. D. (2003) Oxidation affects the flow-induced aggregation of low density lipoprotein and its inhibition by albumin. Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids, 1634 (1-2). pp. 24-29. ISSN 1388-1981 doi: https://doi.org/10.1016/j.bbalip.2003.08.002

Patterson, R. A., Horsley, E. T. M. and Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 (2003) Prooxidant and antioxidant properties of human serum ultrafiltrates toward LDL: important role of uric acid. Journal of Lipid Research, 44 (3). pp. 512-521. ISSN 0022-2275 doi: https://doi.org/10.1194/jlr.M200407-JLR200

Alderman, C. J. J., Bunyard, P. R., Chain, B. M., Foreman, J. C., Leake, D. ORCID: https://orcid.org/0000-0002-1742-6134 and Katz, D. R. (2002) Effects of oxidised low density lipoprotein on dendritic cells: a possible immunoregulatory component of the atherogenic micro-environment? Cardiovascular Research, 55 (4). pp. 806-819. ISSN 0008-6363 doi: https://doi.org/10.1016/S0008-6363(02)00447-9

Leigh-Firbank, E. C., Minihane, A. M., Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134, Wright, J. W., Murphy, M. C., Griffin, B. A. and Williams, C. M. (2002) Eicosapentaenoic acid and docosahexaenoic acid from fish oils: differential associations with lipid responses. British Journal of Nutrition, 87. pp. 435-445. ISSN 0007-1145 doi: https://doi.org/10.1079/BJN2002556

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