Article

Bizley, S. C., Dudhia, J., Smith, R. K. W. and Williams, A. C. ORCID: https://orcid.org/0000-0003-3654-7916 (2023) Transdermal drug delivery in horses: an in vitro comparison of skin structure and permeation of two model drugs at various anatomical sites. Veterinary Dermatology, 34 (3). pp. 235-245. ISSN 1365-3164 doi: https://doi.org/10.1111/vde.13162

Soradech, S., Kengkwasingh, P., Williams, A. C. ORCID: https://orcid.org/0000-0003-3654-7916 and Khutoryanskiy, V. V. (2022) Synthesis and evaluation of poly(3-hydroxypropyl ethylene-imine) and its blends with chitosan forming novel elastic films for delivery of haloperidol. Pharmaceutics, 14 (12). 2671. ISSN 1999-4923 doi: https://doi.org/10.3390/pharmaceutics14122671

Soradech, S., Williams, A. ORCID: https://orcid.org/0000-0003-3654-7916 and Khutoryanskiy, V. (2022) Physically cross-linked cryogels of linear polyethyleneimine: influence of cooling temperature and solvent composition. Macromolecules, 55 (21). pp. 9537-9546. ISSN 0024-9297 doi: https://doi.org/10.1021/acs.macromol.2c01308

Neil, J. E., Brown, M. B., Lenn, J. D. and Williams, A. C. ORCID: https://orcid.org/0000-0003-3654-7916 (2022) Accelerating topical formulation development for inflammatory dermatoses; an ex vivo human skin culture model consistent with clinical therapeutics. International Journal of Pharmaceutics, 618. p. 121648. ISSN 0378-5173 doi: https://doi.org/10.1016/j.ijpharm.2022.121648

Neil, M. S. J. E., Lenn, J. D., Brown, M. B. and Williams, A. C. ORCID: https://orcid.org/0000-0003-3654-7916 (2022) A new ex vivo skin model for mechanistic understanding of putative anti-inflammatory topical therapeutics. International Journal of Pharmaceutics, 617. 121610. ISSN 0378-5173 doi: https://doi.org/10.1016/j.ijpharm.2022.121610

Shan, X., Aspinall, S., Kaldybekov, D. B., Buang, F., Williams, A. C. ORCID: https://orcid.org/0000-0003-3654-7916 and Khutoryanskiy, V. V. (2021) Synthesis and evaluation of methacrylated poly(2-ethyl-2-oxazoline) as a mucoadhesive polymer for nasal drug delivery. ACS Applied Polymer Materials, 3 (11). pp. 5882-5892. ISSN 2637-6105 doi: https://doi.org/10.1021/acsapm.1c01097

Mansfield, E. D. H., Filippov, S. K., de la Rosa, V. R., Cook, M. T., Grillo, I., Hoogenboom, R., Williams, A. C. ORCID: https://orcid.org/0000-0003-3654-7916 and Khutoryanskiy, V. V. (2021) Understanding the temperature induced aggregation of silica nanoparticles decorated with temperature-responsive polymers: can a small step in the chemical structure make a giant leap for a phase transition? Journal of Colloid and Interface Science, 590. pp. 249-259. ISSN 0021-9797 doi: https://doi.org/10.1016/j.jcis.2021.01.044

Shan, X., Moghul, M. A., Williams, A. C. ORCID: https://orcid.org/0000-0003-3654-7916 and Khutoryanskiy, V. V. (2021) Mutual Effects of Hydrogen Bonding and Polymer Hydrophobicity on Ibuprofen Crystal Inhibition in Solid Dispersions with Poly(N-vinyl pyrrolidone) and Poly(2-oxazolines). Pharmaceutics, 13 (5). 659. ISSN 1999-4923 doi: https://doi.org/10.3390/pharmaceutics13050659

Shah, S. I., Khutoryanskiy, V. and Williams, A. C. ORCID: https://orcid.org/0000-0003-3654-7916 (2021) A novel polymer insect repellent conjugate for extended release and decreased skin permeation of Para-Menthane-3,8-Diol. Pharmaceutics, 13 (3). 403. ISSN 1999-4923 doi: https://doi.org/10.3390/pharmaceutics13030403

Al Mahrooqi, J. H., Khutoryanskiy, V. V. and Williams, A. ORCID: https://orcid.org/0000-0003-3654-7916 (2021) Thiolated and PEGylated silica nanoparticle delivery to hair follicles. International Journal of Pharmaceutics, 593. 120130. ISSN 0378-5173 doi: https://doi.org/10.1016/j.ijpharm.2020.120130

Neil, J. E., Brown, M. B. and Williams, A. C. (2020) Human skin explant model for the investigation of topical therapeutics. Scientific Reports, 10 (1). 21192. ISSN 2045-2322 doi: https://doi.org/10.1038/s41598-020-78292-4

Shah, S. I., Williams, A. C., Lau, W. M. and Khutoryanskiy, V. V. (2020) Planarian toxicity fluorescent assay: a rapid and cheap pre-screening tool for potential skin irritants. Toxicology in Vitro, 69. 105004. ISSN 1879-3177 doi: https://doi.org/10.1016/j.tiv.2020.105004

Shan, X., Williams, A. C. and Khutoryanskiy, V. V. (2020) Polymer structure and property effects on solid dispersions with haloperidol: poly(N-vinyl pyrrolidone) and poly(2-oxazolines) studies. International Journal of Pharmaceutics, 590. 119884. ISSN 0378-5173 doi: https://doi.org/10.1016/j.ijpharm.2020.119884

Kademoglou, K., Williams, A. C. and Collins, C. D. (2018) Bioaccessibility of PBDEs present in indoor dust: a novel dialysis membrane method with a Tenax TA® absorption sink. Science of the Total Environment, 621. pp. 1-8. ISSN 0048-9697 doi: https://doi.org/10.1016/j.scitotenv.2017.11.097

Lenn, J. D., Neil, J., Donahue, C., Demock, K., Tibbetts, C. V., Cote-Sierra, J., Smith, S. H., Rubenstein, D., Therrien, J.-P., Pendergrast, P. S., Killough, J., Brown, M. B. and Williams, A. (2018) RNA aptamer delivery through intact human skin. The Journal of Investigative Dermatology, 138 (2). pp. 282-290. ISSN 1523-1747 doi: https://doi.org/10.1016/j.jid.2017.07.851

Al Mahrooqi, J. H., Mun, E. A., Williams, A. C. and Khutoryanskiy, V. V. (2018) Controlling the size of thiolated organosilica nanoparticles. Langmuir, 34 (28). pp. 8347-8354. ISSN 0743-7463 doi: https://doi.org/10.1021/acs.langmuir.8b01556

Mansfield, E. D. H., Pandya, Y., Mun, E. A., Rogers, S. E., Abutbul-Ionita, I., Danino, D., Williams, A. C. and Khutoryanskiy, V. V. (2018) Structure and characterisation of hydroxyethylcellulose–silica nanoparticles. RSC Advances, 8 (12). pp. 6471-6478. ISSN 2046-2069 doi: https://doi.org/10.1039/C7RA08716K

Arezki, N. R., Williams, A. C., Cobb, A. J. A. and Brown, M. B. (2017) Design, synthesis and characterisation of linear unnatural amino acids for skin moisturisation. International Journal of Cosmetic Science, 39 (1). pp. 72-82. ISSN 1468-2494 doi: https://doi.org/10.1111/ics.12351

Arezki, N. R., Williams, A. C., Cobb, A. J. A. and Brown, M. B. (2017) Design, synthesis and characterization of linear unnatural amino acids for skin moisturization. International Journal of Cosmetic Science, 39 (1). pp. 72-82. ISSN 1468-2494 doi: https://doi.org/10.1111/ics.12351

Kabova, E. A., Cole, J. C., Korb, O., Williams, A. C. and Shankland, K. (2017) Improved crystal structure solution from powder diffraction data by the use of conformational information. Journal of Applied Crystallography, 50. pp. 1421-1427. ISSN 0021-8898 doi: https://doi.org/10.1107/S1600576717012596

Kabova, E. A., Cole, J. C., Korb, O., López-Ibáñez, M., Williams, A. and Shankland, K. (2017) Improved performance of crystal structure solution from powder diffraction data through parameter tuning of a simulated annealing algorithm. Journal of Applied Crystallography, 50. pp. 1411-1420. ISSN 0021-8898 doi: https://doi.org/10.1107/S1600576717012602

Mun, E. A., Williams, A. C. and Khutoryanskiy, V. V. (2016) Adhesion of thiolated silica nanoparticles to urinary bladder mucosa: effects of PEGylation, thiol content and particle size. International Journal of Pharmaceutics, 512 (1). pp. 32-38. ISSN 0378-5173 doi: https://doi.org/10.1016/j.ijpharm.2016.08.026

Mansfield, E. D. H., de la Rosa, V. R., Kowalczyk, R. M., Grillo, I., Hoogenboom, R., Sillence, K., Hole, P., Williams, A. C. and Khutoryanskiy, V. V. (2016) Side chain variations radically alter the diffusion of poly(2-alkyl-2-oxazoline) functionalised nanoparticles through a mucosal barrier. Biomaterials Science. ISSN 2047-4830 doi: https://doi.org/10.1039/c6bm00375c

Spillman, M. J., Shankland, K., Williams, A. C. and Cole, J. C. (2015) CDASH: a cloud-enabled program for structure solution from powder diffraction data. Journal of Applied Crystallography, 48 (6). pp. 2033-2039. ISSN 0021-8898 doi: https://doi.org/10.1107/S160057671502049X

Ng, K. W., Lau, W. M. and Williams, A. C. (2015) Towards pain-free diagnosis of skin diseases through multiplexed microneedles: biomarker extraction and detection using a highly sensitive blotting method. Drug Delivery and Translational Research, 5 (4). pp. 387-396. ISSN 2190-393X doi: https://doi.org/10.1007/s13346-015-0231-5

Mansfield, E. D.H., Sillence, K., Hole, P., Williams, A. C. and Khutoryanskiy, V. V. (2015) POZylation: a new approach to enhance nanoparticle diffusion through mucosal barriers. Nanoscale, 7 (32). pp. 13671-13679. ISSN 2040-3364 doi: https://doi.org/10.1039/C5NR03178H

Mun, E. A., Morrison, P. W. J., Williams, A. C. and Khutoryanskiy, V. V. (2014) On the barrier properties of the cornea: a microscopy study of the penetration of fluorescently labeled nanoparticles, polymers, and sodium fluorescein. Molecular Pharmaceutics, 11 (10). pp. 3556-3564. ISSN 1543-8392 doi: https://doi.org/10.1021/mp500332m

Bizley, S. C., Williams, A. C. and Khutoryanskiy, V. V. (2014) Thermodynamic and kinetic properties of interpolymer complexes assessed by isothermal titration calorimetry and surface plasmon resonance. Soft Matter, 10. pp. 8254-8260. ISSN 1744-683X doi: https://doi.org/10.1039/C4SM01138D

Mun, E. A., Hannell, C., Rogers, S. E., Hole, P., Williams, A. C. and Khutoryanskiy, V. V. (2014) On the role of specific interactions in the diffusion of nanoparticles in aqueous polymer solutions. Langmuir, 30 (1). pp. 308-317. ISSN 0743-7463 doi: https://doi.org/10.1021/la4029035

Aravindan, L., Bicknell, K.A., Brooks, G., Khutoryanskiy, V.V. and Williams, A.C. (2013) A comparison of thiolated and disulfide‐crosslinked polyethylenimine for nonviral gene delivery. Macromolecular Bioscience, 13 (9). pp. 1163-1173. ISSN 1616-5187 doi: https://doi.org/10.1002/mabi.201300103

Majumder, M., Buckton, G., Rawlinson, C. F., Williams, A. C., Spillman, M. J., Pidcok, E. and Shankland, K. (2013) Application of hydrogen-bond propensity calculations to an indomethacin–nicotinamide (1:1) co-crystal. CrystEngComm, 15. pp. 4041-4044. ISSN 1466-8033 doi: https://doi.org/10.1039/c3ce40367j

Arif, I. S., Hooper, C. L., Greco, F., Williams, A. C. and Boateng, S. Y. (2013) Increasing doxorubicin activity against breast cancer cells using PPARγ-ligands and by exploiting circadian rhythms. British Journal of Pharmacology, 169 (5). pp. 1178-1188. ISSN 1476-5381 doi: https://doi.org/10.1111/bph.12202

Sogias, I., Williams, A. and Khutoryanskiy, V. (2012) Chitosan-based mucoadhesive tablets for oral delivery of ibuprofen. International Journal of Pharmaceutics, 436 (1-2). pp. 602-610. ISSN 0378-5173 doi: https://doi.org/10.1016/j.ijpharm.2012.07.007

Niemczyk, A. I., Williams, A. C., Rawlinson-Malone, C. F., Hayes, W., Greenland, B., Chappell, D. and Khutoryanskaya, O. (2012) Novel polyvinylpyrrolidones to improve delivery of poorly-water soluble drugs; from design to synthesis and evaluation. Molecular Pharmaceutics, 9 (8). pp. 2237-2247. ISSN 1543-8392 doi: https://doi.org/10.1021/mp300079x

Bizley, S. C., Williams, A. C., Kemp, F. and Khutoryanskiy, V. V. (2012) Optimizing layer-by-layer deposition of interpolymer complexes on solid substrates using Biacore. Soft Matter, 8 (25). pp. 6782-6787. ISSN 1744-683X doi: https://doi.org/10.1039/C2SM25652E

Majumder, M., Buckton, G., Rawlinson-Malone, C., Williams, A. C., Spillman, M. J., Shankland, N. and Shankland, K. (2011) A carbamazepine-indomethacin (1 : 1) cocrystal produced by milling. Crystengcomm, 13 (21). pp. 6327-6328. ISSN 1466-8033 doi: https://doi.org/10.1039/c1ce05650f

Rizi, K., Green, B., Donaldson, M. and Williams, A. (2011) Production of pH-responsive microparticles by spray drying: investigation of experimental parameter effects on morphological and release properties. Journal of Pharmaceutical Sciences, 100 (2). pp. 566-579. ISSN 1520-6017 doi: https://doi.org/10.1002/jps.22291

Rizi, K., Green, R. J., Khutoryanskaya, O., Donaldson, M. and Williams, A. C. (2011) Mechanisms of burst release from pH-responsive polymeric microparticles. Journal of Pharmacy and Pharmacology, 63 (9). pp. 1141-1155. ISSN 0022-3573 doi: https://doi.org/10.1111/j.2042-7158.2011.01322.x

Rizi, K., Green, R. J., Donaldson, M. X. and Williams, A. C. (2011) Using pH abnormalities in diseased skin to trigger and target topical therapy. Pharmaceutical Research, 28 (10). pp. 2589-2598. ISSN 0724-8741 doi: https://doi.org/10.1007/s11095-011-0488-4

Majumder, M., Buckton, G., Rawlinson-Malone, C., Williams, A., Spillman, M., Shankland, N. and Shankland, K. (2011) A carbamazepine-indomethacin (1:1) cocrystal produced by milling. Crystengcomm, 13 (21). pp. 6327-6328. ISSN 1466-8033 doi: https://doi.org/10.1039/c1ce05650f

Ali, W., Williams, A. C. and Rawlinson, C. F. (2010) Stochiometrically governed molecular interactions in drug: Poloxamer solid dispersions. International Journal of Pharmaceutics, 391 (1-2). pp. 162-168. ISSN 0378-5173 doi: https://doi.org/10.1016/j.ijpharm.2010.03.014

Sogias, I., Khutoryanskiy, V. V. and Williams, A. C. (2010) Exploring the Factors Affecting the Solubility of Chitosan in Water. Macromolecular Chemistry and Physics, 211 (4). pp. 426-433. ISSN 1022-1352 doi: https://doi.org/10.1002/macp.200900385

Aravindan, L. , Bicknell, K. A., Brooks, G., Khutoryanskiy, V. V. and Williams, A. C. (2009) Effect of acyl chain length on transfection efficiency and toxicity of polyethylenimine. International Journal of Pharmaceutics, 378 (1-2). pp. 201-210. ISSN 0378-5173 doi: https://doi.org/10.1016/j.ijpharm.2009.05.052

El Maghraby, G. M. and Williams, A. C. (2009) Vesicular systems for delivering conventional small organic molecules and larger macromolecules to and through human skin. Expert Opinion on Drug Delivery, 6 (2). pp. 149-163. ISSN 1742-5247 doi: https://doi.org/10.1517/17425240802691059

Sogias, I., Williams, A. C. and Khutoryanskiy, V. V. (2008) Why is Chitosan Mucoadhesive? Biomacromolecules, 9 (7). pp. 1837-1842. ISSN 1525-7797 doi: https://doi.org/10.1021/bm800276d

Maghraby, G. M., Barry, B. W. and Williams, A. C. (2008) Liposomes and skin: From drug delivery to model membranes. European Journal of Pharmaceutical Sciences, 34 (4-5). pp. 203-222. ISSN 0928-0987 doi: https://doi.org/10.1016/j.ejps.2008.05.002

Rawlinson, C.F., Williams, A.C., Timmins, P. and Grimsey, I. (2007) Polymer-mediated disruption of drug crystallinity. International Journal of Pharmaceutics, 336 (1). pp. 42-48. ISSN 0378-5173 doi: https://doi.org/10.1016/j.ijpharm.2006.11.029

Dematos, L.L., Williams, A.C., Booth, S.W., Petts, C.R., Taylor, D.J. and Blagden, N. (2007) Solvent influences on metastable polymorph lifetimes: real-time interconversions using energy dispersive X-ray diffractometry. Journal of Pharmaceutical Sciences, 96 (5). pp. 1069-1078. ISSN 0022-3549 doi: https://doi.org/10.1002/jps.20924

Khutoryanskaya, O.V., Williams, A.C. and Khutoryanskiy, V.V. (2007) pH-mediated interactions between poly(acrylic acid) and methylcellulose in the formation of ultrathin multilayered hydrogels and spherical nanoparticles. Macromolecules, 40 (21). pp. 7707-7713. ISSN 0024-9297 doi: https://doi.org/10.1021/ma071644v

El Maghraby, G.M.M., Williams, A.C. and Barry, B.W. (2006) Can drug-bearing liposomes penetrate intact skin? Journal of Pharmacy and Pharmacology, 58 (4). pp. 415-429. ISSN 0022-3573 doi: https://doi.org/10.1211/jpp.58.4.0001

Williams, A. C., Edwards, H. G. M., Lawson, E. E. and Barry, B. W. (2006) Molecular interactions between the penetration enhancer 1,8-cineole and human skin. Journal of Raman Spectroscopy, 37 (1-3). pp. 361-366. ISSN 0377-0486 doi: https://doi.org/10.1002/jrs.1468

Tekko, I.A., Bonner, M.C., Bowen, R.D. and Williams, A.C. (2006) Permeation of bioactive constituents from Arnica montana preparations through human skin in-vitro. Journal of Pharmacy and Pharmacology, 58 (9). pp. 1167-1176. ISSN 0022-3573 doi: https://doi.org/10.1211/jpp.58.9.0002

Tekko, I.A., Bonner, M.C. and Williams, A.C. (2006) An optimized reverse-phase high performance liquid chromatographic method for evaluating percutaneous absorption of glucosamine hydrochloride. Journal of Pharmaceutical and Biomedical Analysis, 41 (2). pp. 385-392. ISSN 0731-7085 doi: https://doi.org/10.1016/j.jpba.2005.11.044

Williams, A. C., Timmins, P., Lu, M. C. and Forbes, R. T. (2005) Disorder and dissolution enhancement: Deposition of ibuprofen on to insoluble polymers. European Journal of Pharmaceutical Sciences, 26 (3-4). pp. 288-294. ISSN 0928-0987 doi: https://doi.org/10.1016/j.ejps.2005.06.006

El Maghraby, G.M.M., Williams, A.C. and Barry, B.W. (2005) Drug interaction and location in liposomes: correlation with polar surface areas. International Journal of Pharmaceutics, 292 (1-2). pp. 179-185. ISSN 0378-5173 doi: https://doi.org/10.1016/j.ijpharm.2004.11.037

Williams, A. C., Cooper, V. B., Thomas, L., Griffith, L. J., Petts, C. R. and Booth, S. W. (2004) Evaluation of drug physical form during granulation, tabletting and storage. International Journal of Pharmaceutics, 275 (1-2). pp. 29-39. ISSN 0378-5173 doi: https://doi.org/10.1016/j.ijpharm.2004.01.042

El Maghraby, G. M. M., Williams, A. C. and Barry, B. W. . (2004) Interactions of surfactants (edge activators) and skin penetration enhancers with liposomes. International Journal of Pharmaceutics, 276 (1-2). pp. 143-161. ISSN 0378-5173 doi: https://doi.org/10.1016/j.ijpharm.2004.02.024

Ahmed, A., Barry, B. W., Williams, A. C. and Davis, A. F. (2004) Penciclovir solubility in Eudragit films: a comparison of X-ray, thermal, microscopic and release rate techniques. Journal of Pharmaceutical and Biomedical Analysis, 34. pp. 945-956. ISSN 0731-7085 doi: https://doi.org/10.1016/j.jpba.2003.11.018

O'Brien, L. E., Timmins, P., Williams, A. and York, P. (2004) Use of in situ FT-Raman spectroscopy to study the kinetics of the transformation of carbamazepine polymorphs. Journal of Pharmaceutical and Biomedical Analysis, 36 (2). pp. 335-340. ISSN 0731-7085 doi: https://doi.org/10.1016/j.jpba.2004.06.024

Caspers, P. J., Williams, A. C., Carter, E. A., Edwards, H. G. M., Barry, B. W., Bruining, H. A. and Pupples, G. J. (2002) Monitoring the penetration enhancer dimethyl sulfoxide in human stratum corneum in vivo by confocal raman spectroscopy. Pharmaceutical Research, 19 (10). pp. 1577-1580. ISSN 0724-8741 doi: https://doi.org/10.1023/A:1020481305420

Campbell Roberts, S. N. C., Williams, A. C., Grimsey, I. M. and Booth, S. W. (2002) Quantitative analysis of mannitol polymorphs: FT-Raman spectroscopy. Journal of Pharmaceutical and Biomedical Analysis, 28. pp. 1135-1147. ISSN 0731-7085 doi: https://doi.org/10.1016/S0731-7085(02)00059-6

Campbell Roberts, S. N. C., Williams, A. C., Grimsey, I. M. and Booth, S. W. (2002) Quantitative analysis of mannitol polymorphs: X-ray powder diffractometry—exploring preferred orientation effects. Journal of Pharmaceutical and Biomedical Analysis, 28 (6). pp. 1149-1159. ISSN 0731-7085 doi: https://doi.org/10.1016/S0731-7085(02)00053-5

Sznitowska, M., Janicki, S. and Williams, A. C. (1998) Intracellular or intercellular localization of the polar pathway of penetration across stratum corneum. Journal of Pharmaceutical Sciences, 87 (9). pp. 1109-1114. ISSN 1520-6017 doi: https://doi.org/10.1021/js980018w

Book or Report Section

Williams, A. ORCID: https://orcid.org/0000-0003-3654-7916 (2021) Controlled Drug Delivery into and Through Skin. In: Benson, H. A. E., Roberts, M. S., Williams, A. C. ORCID: https://orcid.org/0000-0003-3654-7916 and Liang, X. (eds.) Fundamentals of Drug Delivery. Wiley, pp. 507-534. ISBN 9781119769644 doi: https://doi.org/10.1002/9781119769644.ch20

Williams, A. ORCID: https://orcid.org/0000-0003-3654-7916 (2021) Drug Delivery of the Future (?). In: Benson, H. A. E., Roberts, M. S., Williams, A. C. ORCID: https://orcid.org/0000-0003-3654-7916 and Liang, X. (eds.) Fundamentals of Drug Delivery. Wiley, pp. 39-51. ISBN 9781119769644 doi: https://doi.org/10.1002/9781119769644.ch3

Mansfield, E. D. H., Williams, A. C. and Khutoryanskiy, V. V. (2018) Applications of temperature-responsive polymers grafted onto solid core nanoparticles. In: Khutoryanskiy, V. V. and Georgiou, T. K. (eds.) Temperature-Responsive Polymers: Chemistry, Properties, and Applications. Wiley and sons, pp. 281-299, 408 pp.. ISBN 9781119157786

Book

Benson, H. A. E., Roberts, M. S. and Williams, A. C. ORCID: https://orcid.org/0000-0003-3654-7916, eds. (2021) Fundamentals of Drug Delivery. Wiley, pp576. ISBN 9781119769675