Article

Wang, X., Gibson, G. R., Costabile, A., Sailer, M., Theis, S. and Rastall, R. A. (2019) Prebiotic supplementation of In Vitro fecal fermentations inhibits proteolysis by gut bacteria, and host diet shapes gut bacterial metabolism and response to intervention. Applied and Environmental Microbiology, 85 (9). e02749-18. ISSN 1098-5336 doi: https://doi.org/10.1128/AEM.02749-18

Alemán, J. O., Bokulich, N. A., Swann, J. R., Walker, J. M., De Rosa, J. C., Battaglia, T., Costabile, A., Pechlivanis, A., Liang, Y., Breslow, J. L., Blaser, M. J. and Holt, P. R. (2018) Fecal microbiota and bile acid interactions with systemic and adipose tissue metabolism in diet-induced weight loss of obese postmenopausal women. Journal of Translational Medicine, 16 (1). 244. ISSN 1479-5876 doi: https://doi.org/10.1186/s12967-018-1619-z

Grimaldi, R., Gibson, G. R., Vulevic, J., Giallourou, N., Castro-Mejía, J. L., Hansen, L. H., Gibson, E. L., Nielsen, D. S. and Costabile, A. (2018) A prebiotic intervention study in children with autism spectrum disorders (ASDs). Microbiome, 6 (1). 133. ISSN 2049-2618 doi: https://doi.org/10.1186/s40168-018-0523-3

Costabile, A., Bergillos-Meca, T., Raskinkangas, P., Korpela, K., de Vos, W. M. and Gibson, G. R. (2017) Effects of soluble corn fiber alone or in synbiotic combination with Lactobacillus rhamnosus GG and the Pilus-deficient derivative GG-PB12 on fecal microbiota, metabolism, and markers of immune function: a randomized, double-blind, placebo-controlled, crossover study in healthy elderly (Saimes study). Frontiers in Immunology, 8. 1443. ISSN 1664-3224 doi: https://doi.org/10.3389/fimmu.2017.01443

Alqurashi, R. M., Alarifi, S. N., Walton, G. E., Costabile, A. F., Rowland, I. R. and Commane, D. M. (2017) In vitro approaches to assess the effects of açai (Euterpe oleracea) digestion on polyphenol availability and the subsequent impact on the faecal microbiota. Food Chemistry, 234. pp. 190-198. ISSN 0308-8146 doi: https://doi.org/10.1016/j.foodchem.2017.04.164

Grimaldi, R., Cela, D., Swann, J. R., Vulevic, J., Gibson, G. R., Tzortzis, G. and Costabile, A. (2017) In vitro fermentation of B-GOS: impact on faecal bacterial populations and metabolic activity in autistic and non-autistic children. FEMS Microbiology Ecology, 93 (2). fiw233. ISSN 1574-6941 doi: https://doi.org/10.1093/femsec/fiw233

Bevilacqua, A., Costabile, A., Bergillos-Meca, T., Gonzalez-Salvador, I., Landriscina, L., Ciuffreda, E., D'Agnello, P., Corbo, M. R., Sinigaglia, M. and Lamacchia, C. (2016) Impact of gluten-friendly bread on the metabolism and function of in vitro gut microbiota in healthy human and coeliac subjects. PLoS ONE, 11 (9). e0162770. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0162770

Pérez-López, E., Cela, D., Costabile, A., Mateos-Aparicio, I. and Rupérez, P. (2016) In vitro fermentability and prebiotic potential of soyabean Okara by human faecal microbiota. British Journal of Nutrition, 116 (06). pp. 1116-1124. ISSN 1475-2662 doi: https://doi.org/10.1017/S0007114516002816

de Barros, J. M.S., Costabile, A., Charalampopoulos, D. ORCID: https://orcid.org/0000-0003-1269-8402, Khutoryanskiy, V. V. and Edwards, A. D. (2016) Evaluating and optimizing oral formulations of live bacterial vaccines using a gastro-small intestine model. European Journal of Pharmaceutics and Biopharmaceutics, 102. pp. 115-122. ISSN 0939-6411 doi: https://doi.org/10.1016/j.ejpb.2016.03.010

Guergoletto, K. B., Costabile, A., Flores, G., Garcia, S. and Gibson, G. R. (2016) In vitro fermentation of juçara pulp (Euterpe edulis) by human colonic microbiota. Food Chemistry, 196. pp. 251-258. ISSN 0308-8146 doi: https://doi.org/10.1016/j.foodchem.2015.09.048

Grimaldi, R., Swann, J. R., Vulevic, J., Gibson, G. R. and Costabile, A. (2016) Fermentation properties and potential prebiotic activity of Bimuno® galacto-oligosaccharide (65 % galacto-oligosaccharide content) on in vitro gut microbiota parameters. British Journal of Nutrition, 116 (3). pp. 480-486. ISSN 0007-1145 doi: https://doi.org/10.1017/S0007114516002269

Costabile, A., Deaville, E. R., Morales, A. M. and Gibson, G. R. (2016) Prebiotic potential of a maize-based soluble fibre and impact of dose on the human gut microbiota. PLoS ONE, 11 (1). e0144457. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0144457

Massot-Cladera, M., Costabile, A., Childs, C. E., Yaqoob, P., Franch, A., Castell, M. and Perez-Cano, F. J. (2015) Prebiotic effects of cocoa fibre on rats. Journal of Functional Foods, 19. pp. 341-352. ISSN 1756-4646 doi: https://doi.org/10.1016/j.jff.2015.09.021

Sannasiddappa, T., Hood, G., Hanson, K., Costabile, A., Gibson, G. and Clarke, S. (2015) Staphylococcus aureus MnhF mediates cholate efflux and facilitates survival under human colonic conditions. Infection and Immunity, 83 (6). pp. 2350-2357. ISSN 0019-9567 doi: https://doi.org/10.1128/IAI.00238-15

Costabile, A., Walton, G. E., Tzortzis, G., Vulevic, J., Charalampopoulos, D. and Gibson, G. R. (2015) Effects of orange juice formulation on prebiotic functionality using an in vitro colonic model sytem. PLoS ONE, 10 (3). e0121955. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0121955

Bergillos-Meca, T., Costabile, A., Walton, G., Moreno-Montoro, M., Ruiz-Bravo, A. and Ruiz-López, M. D. (2015) In vitro evaluation of the fermentation properties and potential probiotic activity of Lactobacillus plantarum C4 in batch culture systems. LWT-Food Science and Technology, 60 (1). pp. 420-426. ISSN 0023-6438 doi: https://doi.org/10.1016/j.lwt.2014.08.006

Eid, N., Osmanova, H., Natchez, C., Walton, G., Costabile, A., Gibson, G., Rowland, I. and Spencer, J. P.E. (2015) Impact of palm date consumption on microbiota growth and large intestinal health: a randomised, controlled, cross-over, human intervention study. British Journal of Nutrition, 114 (8). pp. 1226-1236. ISSN 1475-2662 doi: https://doi.org/10.1017/S0007114515002780

Ramnani, P., Costabile, A., Bustillo, A. G. R. and Gibson, G. R. (2015) A randomised, double- blind, cross-over study investigating the prebiotic effect of agave fructans in healthy human subjects. Journal of Nutritional Science, 4. e10. ISSN 2048-6790 doi: https://doi.org/10.1017/jns.2014.68

Costabile, A., Santarelli, S., Claus, S. P., Sanderson, J., Hudspith, B. N., Brostoff, J., Ward, J. L., Lovegrove, A., Shewry, P. R., Jones, H. E., Whitley, A. M. and Gibson, G. R. (2014) Effect of breadmaking process on In Vitro gut microbiota parameters in irritable bowel syndrome. PLoS ONE, 9 (10). e111225. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0111225

Eid, N., Enani, S., Walton, G., Corona, G., Costabile, A., Gibson, G., Rowland, I. and Spencer, J. P. E. (2014) The impact of date palm fruits and their component polyphenols, on gut microbial ecology, bacterial metabolites and colon cancer cell proliferation. Journal of nutritional science, 3. e46. ISSN 2048-6790 doi: https://doi.org/10.1017/jns.2014.16

Frost, G. S., Walton, G. E. ORCID: https://orcid.org/0000-0001-5426-5635, Swann, J. R., Psichas, A., Costabile, A., Johnson, L. P., Sponheimer, M., Gibson, G. R. and Barraclough, T. G. (2014) Impacts of plant-based foods in ancestral hominin diets on the metabolism and function of gut microbiota in vitro. mBio, 5. e00853-14. ISSN 2150-7511 doi: https://doi.org/10.1128/mbio.00853-14

Bodinham, C. L., Smith, L., Thomas, E. L., Bell, J. D., Swann, J. R., Costabile, A., Russell-Jones, D., Umpleby, A. M. and Robertson, M. D. (2014) Efficacy of increased resistant starch consumption in human type 2 diabetes. Endocrine connections, 3 (2). pp. 75-84. ISSN 2049-3614 doi: https://doi.org/10.1530/EC-14-0036

Eid, N., Walton, G., Costabile, A., Kuhnle, G. G. C. and Spencer, J. P. E. (2014) Polyphenols, glucosinolates, dietary fibre and colon cancer: Understanding the potential of specific types of fruit and vegetables to reduce bowel cancer progression. Nutrition and Aging, 2 (1). pp. 45-67. ISSN 1879-7725 doi: https://doi.org/10.3233/NUA-130029

Daud, N. M., Ismail, N. A., Thomas, E. L., Fitzpatrick, J. A., Bell, J. D., Swann, J. R., Costabile, A., Childs, C. E., Pedersen, C., Goldstone, A. P. and Frost, G. S. (2014) The impact of oligofructose on stimulation of gut hormones, appetite regulation, and adiposity. Obesity, 22 (6). pp. 1430-1438. ISSN 1930-739X doi: https://doi.org/10.1002/oby.20754

Tejero-Sarinena, S., Barlow, J., Costabile, A., Gibson, G. R. and Rowland, I. (2013) Antipathogenic activity of probiotics against Salmonella Typhimurium and Clostridium difficile in anaerobic batch culture systems: is it due to synergies in probiotic mixtures or the specificity of single strains? Anaerobe, 24. pp. 60-65. ISSN 1075-9964 doi: https://doi.org/10.1016/j.anaerobe.2013.09.011

Hobden, M. R., Martin-Morales, A., Guerin-Deremaux, L., Wils, D., Costabile, A., Walton, G. E., Rowland, I., Kennedy, O. B. and Gibson, G. R. (2013) In Vitro Fermentation of NUTRIOSE® FB06, a wheat dextrin soluble fibre, in a continuous culture human colonic model system. PLoS ONE, 8 (10). e77128. doi: https://doi.org/10.1371/journal.pone.0077128

Maki, K. C., Gibson, G. R., Dickmann, R. S., Kendall, C. W., Oliver Chen, C.-Y., Costabile, A., Comeli, E. M., McKay, D. L., Almedia, N. G., Jenkins, D., Zello, G. A. and Blumberg, J. B. (2012) Digestive and physiologic effects of a wheat bran extract, arabino-xylan-oligosaccharide, in breakfast cereal. Nutrition, 28 (11-12). pp. 1151-1121. ISSN 0899-9007 doi: https://doi.org/10.1016/j.nut.2012.02.010

Tejero-Sariñena, S., Barlow, J., Costabile, A., Gibson, G. R. and Rowland, I. (2012) In vitro evaluation of the antimicrobial activity of a range of probiotics against pathogens: Evidence for the effects of organic acids. Anaerobe, 18 (5). pp. 530-538. ISSN 1075-9964 doi: https://doi.org/10.1016/j.anaerobe.2012.08.004

Costabile, A., Fava, F., Roytio, H., Forssten, S. D., Olli, K., Klievink, J., Rowland, I. R., Ouwehand, A. C., Rastall, R. A., Gibson, G. R. and Walton, G. E. (2012) Impact of polydextrose on the faecal microbiota: a double-blind, crossover, placebo-controlled feeding study in healthy human subjects. British Journal of Nutrition, 108 (3). pp. 471-481. ISSN 1475-2662 doi: https://doi.org/10.1017/S0007114511005782

Oliveira, D. L., Costabile, A., Wilbey, R., Grandison, A. S., Duarte, L. C. and Roseiro, L. B. (2012) In vitro evaluation of the fermentation properties and potential prebiotic activity of caprine cheese whey oligosaccharides in batch culture systems. BioFactors, 38 (6). pp. 440-449. ISSN 1872-8081 doi: https://doi.org/10.1002/biof.1043

Maccaferri, S., Klinder, A., Cacciatore, S., Chittarari, R., Honda, H., Luchinat, C., Bertini, I., Carnevali, P., Gibson, G. R., Brigidi, P. and Costabile, A. (2012) In vitro fermentation of potential prebiotic flours from natural sources: impact on the human colonic microbiota and metabolome. Molecular Nutrition & Food Research, 56 (8). pp. 1342-1352. ISSN 1613-4125 doi: https://doi.org/10.1002/mnfr.201200046

Sannasiddappa, T.H., Costabile, A., Gibson, G. and Clarke, S. (2011) The influence of Staphylococcus aureus on gut microbial ecology in an in vitro continuous culture human colonic model system. PLoS ONE, 6 (8). E23227. ISSN 1932-6203

Fogliano, V., Corollaro, M. L., Vitaglione, P., Napolitano, A., Ferracane, R., Travaglia, F., Arlorio, M., Costabile, A., Klinder, A. and Gibson, G. (2011) In vitro bioaccessibility and gut biotransformation of polyphenols present in the water-insoluble cocoa fraction. Molecular Nutrition & Food Research, 55 (Supplement). pp. 44-55. ISSN 1613-4125 doi: https://doi.org/10.1002/mnfr.201000360

Costabile, A., Sanghi, S., Martin-Palaez, S., Mueller-Harvey, I., Gibson, G. R., Rastall, R. A. and Klinder, A. (2011) Inhibition of Salmonella Typhimurium by tannins in vitro. Journal of Food, Agriculture & Environment, 9 (1). pp. 119-124. ISSN 1459-0263

Maccaferri, S., Vitali, B., Klinder, A., Kolida, S., Ndagijimana, M., Laghi, L., Calanni, F., Brigidi, P., Gibson, G. R. and Costabile, A. (2010) Rifaximin modulates the colonic microbiota of patients with Crohn's disease: an in vitro approach using a continuous culture colonic model system. Journal of Antimicrobial Chemotherapy, 65 (12). pp. 2556-2565. ISSN 0305-7453 doi: https://doi.org/10.1093/jac/dkq345

Costabile, A., Kolida, S., Klinder, A., Gielt, E., Bäuerlein, M., Frohberg, C., Landschütze, V. and Gibson, G. R. (2010) A double-blind, placebo-controlled, cross-over study to establish the bifidogenic effect of a very-long-chain inulin extracted from globe artichoke (Cynara scolymus) in healthy human subjects. British Journal of Nutrition, 104 (7). pp. 1007-1017. ISSN 1475-2662 doi: https://doi.org/10.1017/S0007114510001571

Gomez, E., Tuohy, K.M., Gibson, G.R., Klinder, A. and Costabile, A. (2010) In vitro evaluation of the fermentation properties and potential prebiotic activity of Agave fructans. Journal of Applied Microbiology, 108 (6). pp. 2114-2121. ISSN 1364-5072 doi: https://doi.org/10.1111/j.1365-2672.2009.04617.x

Martin-Pelaez, S., Costabile, A., Hoyles, L., Rastall, R. A., Gibson, G. R., Mateu, E., Martin-Orue, S. M., La Ragione, R. M. and Woodward, M. J. (2010) Evaluation of the inclusion of a mixture of organic acids or lactulose into the feed of pigs experimentally challenged with Salmonella Typhimurium. Veterinary Microbiology, 142 (3-4). pp. 337-345. ISSN 0378-1135 doi: https://doi.org/10.1016/j.vetmic.2009.09.061

Swann, J., Wang, Y., Abecia, L., Costabile, A., Tuohy, K., Gibson, G., Roberts, D., Sidaway, J., Jones, H., Wilson, I. D., Nicholson, J. and Holmes, E. (2009) Gut microbiome modulates the toxicity of hydrazine: a metabonomic study. Molecular Biosystems, 5. pp. 351-355. ISSN 1742-206X

Napolitano, A., Costabile, A., Martin-Pelaiez, S., Vitaglione, P., Klinder, A., Gibson, G. R. and Fogliano, V. (2009) Potential prebiotic activity of oligosaccharides obtained by enzymatic conversion of durum wheat insoluble dietary fibre into soluble dietary fibre. Nutrition Metabolism and Cardiovascular Diseases, 19 (4). pp. 283-290. ISSN 0939-4753 doi: https://doi.org/10.1016/j.numecd.2008.07.005

Tuohy, K.M., Costabile, A. and Fava, F. (2009) The gut microbiota in obesity and metabolic disease - a novel therapeutic target. Nutritional Therapy & Metabolism, 27 (3). pp. 113-133. ISSN 1828-6232

Martin-Pelaez, S., Gibson, G. R., Martin-Orue, S. M., Klinder, A., Rastall, R. A., La Ragione, R. M., Woodward, M. J. and Costabile, A. (2008) In vitro fermentation of carbohydrates by porcine faecal inocula and their influence on Salmonella Typhimurium growth in batch culture systems. Fems Microbiology Ecology, 66 (3). pp. 608-619. ISSN 0168-6496 doi: https://doi.org/10.1111/j.1574-6941.2008.00610.x

Costabile, A., Klinder, A., Fava, F., Napolitano, A., Foglian, V., Leonard, C., Gibson, G. R. and Tuohy, K. M. (2008) Whole-grain wheat breakfast cereal has a prebiotic effect on the human gut microbiota: a double-blind, placebo-controlled, crossover study. British Journal of Nutrition, 99 (1). pp. 110-120. ISSN 0007-1145 doi: https://doi.org/10.1017/s0007114507793923