Article

Ingrande, J., Patel, H. H., Kendall, D., Stefanska, B., Alexander, S., Bakhle, M., Cirino, G., Docherty, J. R., George, C. H., Insel, P. A., Ji, Y., King, B. F., Lilley, E., Panettieri, R. A., Ramage, A. G., Sobey, C. G., Stanford, S. C., Stephens, G. ORCID: https://orcid.org/0000-0002-8966-4238, Teixeira, M., Vergnolle, N. and Ahluwalia, A. (2023) Guidance for the use and reporting of anaesthetic agents in BJP manuscripts involving work with animals. British Journal of Pharmacology, 180 (3). pp. 255-263. ISSN 0007-1188 doi: https://doi.org/10.1111/bph.15992

Day, C., Silva, J.-P., Munro, R., Baker, T. S., Wolff, C., Bithell, A. and Stephens, G. J. ORCID: https://orcid.org/0000-0002-8966-4238 (2023) Anti-AMPA receptor autoantibodies reduce excitatory currents in rat hippocampal neurons. Pharmaceuticals, 16 (1). 77. ISSN 1424-8247 doi: https://doi.org/10.3390/ph16010077

Kaisis, E., Thei, L. J., Stephens, G. J. ORCID: https://orcid.org/0000-0002-8966-4238 and Dallas, M. L. ORCID: https://orcid.org/0000-0002-5190-0522 (2022) Protofibrillar amyloid beta modulation of recombinant hCaV2.2 (N-type) voltage-gated channels. Pharmaceuticals, 15 (12). 1459. ISSN 1424-8247 doi: https://doi.org/10.3390/ph15121459

Ablinger, C., Eibl, C., Geisler, S. M., Campiglio, M., Stephens, G. J. ORCID: https://orcid.org/0000-0002-8966-4238, Missler, M. and Obermair, G. J. (2022) α2δ-4 and Cachd1 proteins are regulators of presynaptic functions. International Journal of Molecular Sciences, 23 (17). 9885. ISSN 1422-0067 doi: https://doi.org/10.3390/ijms23179885

Curtis, M. J., Alexander, S. P. H., Cirino, G., George, C. H., Kendall, D. A., Insel, P. A., Izzo, A. A., Ji, Y., Panettieri, R. A., Patel, H. H., Sobey, C. G., Stanford, S. C., Stanley, P., Stefanska, B., Stephens, G. ORCID: https://orcid.org/0000-0002-8966-4238, Teixeira, M. M., Vergnolle, N. and Ahluwalia, A. (2022) Planning experiments: updated guidance on experimental design and analysis and their reporting III. British Journal of Pharmacology, 179 (15). pp. 3907-3913. ISSN 0007-1188 doi: https://doi.org/10.1111/bph.15868

Banazadeh, M., Olangian-Tehrani, S., Sharifi, M., Malek- Ahmadi, M., Nikzad, F., Doozandeh- Nargesi, N., Mohammadi, A., Stephens, G. J. ORCID: https://orcid.org/0000-0002-8966-4238 and Shabani, M. (2022) Mechanisms of COVID-19-induced cerebellitis. Current medical research and opinion, 38 (12). pp. 2109-2118. ISSN 0300-799 doi: https://doi.org/10.1080/03007995.2022.2141963

Stephens, G. J. ORCID: https://orcid.org/0000-0002-8966-4238 and Shukla, A. K. (2022) Targeting the cell's gatekeepers for novel drug discovery. British Journal of Pharmacology, 179 (14). pp. 3485-3486. ISSN 0007-1188 doi: https://doi.org/10.1111/bph.15831

George, C. H., Alexander, S. P. H., Cirino, G., Insel, P. A., Izzo, A. A., JI, Y., Kendall, D. A., Panettieri, R. A., Patel, H. H., Sobey, C. G., Stanford, S. C., Stefanska, B., Stephens, G. ORCID: https://orcid.org/0000-0002-8966-4238, Teixeira, M. and Ahluwalia, A. (2021) Editorial policy regarding the citation of preprints in the British Journal of Pharmacology (BJP). British Journal of Pharmacology, 178 (18). pp. 3605-3610. ISSN 0007-1188 doi: https://doi.org/10.1111/bph.15589

Silveirinha, V., Lin, H., Tanifuji, S., Mochida, S., Cottrell, G. ORCID: https://orcid.org/0000-0001-9098-7627, Cimarosti, H. and Stephens, G. ORCID: https://orcid.org/0000-0002-8966-4238 (2021) CaV2.2 (N-type) voltage-gated calcium channels are activated by SUMOylation pathways. Cell Calcium, 93. 102326. ISSN 0143-4160 doi: https://doi.org/10.1016/j.ceca.2020.102326

Williams, C. ORCID: https://orcid.org/0000-0003-4452-671X and Stephens, G. ORCID: https://orcid.org/0000-0002-8966-4238 (2020) Development of cannabidiol as a treatment for severe childhood epilepsies. British Journal of Pharmacology, 177 (24). pp. 5509-5517. ISSN 0007-1188 doi: https://doi.org/10.1111/bph.15274

Lilley, E., Stanford, S. C., Kendall, D. E., Alexander, S. P. H., Cirino, G., Docherty, J. R., George, C. H., Insel, P. A., Izzo, A. A., Ji, Y., Panettieri, R. A., Sobey, C. G., Stefanska, B., Stephens, G., Teixeira, M. and Ahluwalia, A. (2020) ARRIVE 2.0 and the British Journal of Pharmacology: updated guidance for 2020. British Journal of Pharmacology, 177 (16). pp. 3611-3616. ISSN 0007-1188 doi: https://doi.org/10.1111/bph.15178

Natfji, A. A., Nikitin, D. O., Semina, I. I., Moustafine, R. I., Khutoryanskiy, V. V., Lin, H., Stephens, G. J., Watson, K. A., Osborn, H. M. I. and Greco, F. (2020) Conjugation of haloperidol to PEG allows peripheral localisation of haloperidol and eliminates CNS extrapyramidal effects. Journal of Controlled Release, 322. pp. 227-235. ISSN 0168-3659 doi: https://doi.org/10.1016/j.jconrel.2020.02.037

Izzo, A. A., Teixeira, M., Alexander, S. P.H., Cirino, G., Docherty, J. R., George, C. H., Insel, P. A., Ji, Y., Kendall, D. A., Panattieri, R. A., Sobey, C. G., Stanford, S. C., Stefanska, B., Stephens, G. and Ahluwalia, A. (2020) A practical guide for transparent reporting of research on natural products in the British Journal of Pharmacology: reproducibility of natural product research. British Journal of Pharmacology, 177 (10). pp. 2169-2178. ISSN 0007-1188 doi: https://doi.org/10.1111/bph.15054

Docherty, J. R., Stanford, S. C., Panattieri, R. A., Alexander, S. P.H., Cirino, G., George, C. H., Hoyer, D., Izzo, A. A., Ji, Y., Lilley, E., Sobey, C. G., Stanley, P., Stefanska, B., Stephens, G., Teixeira, M. and Ahluwalia, A. (2019) Sex: a change in our guidelines to authors to ensure that this is no longer an ignored experimental variable. British Journal of Pharmacology, 176 (21). pp. 4081-4086. ISSN 0007-1188 doi: https://doi.org/10.1111/bph.14761

Tabatabaee, S., Baker, D., Selwood, D. L., Whalley, B. J. and Stephens, G. J. (2019) The Cannabinoid-Like Compound, VSN16R, Acts on Large Conductance, Ca2+-Activated K+ Channels to Modulate Hippocampal CA1 Pyramidal Neuron Firing. Pharmaceuticals, 12 (3). 104. ISSN 1424-8247 doi: https://doi.org/10.3390/ph12030104

Stephens, G. J. and Cottrell, G. S. (2019) CACHD1: a new activity-modifying protein for voltage-gated calcium channels. Channels, 13 (1). pp. 120-123. ISSN 1933-6969 doi: https://doi.org/10.1080/19336950.2019.1600968

Whalley, B. J., Lin, H., Bell, L., Hill, T., Patel, A., Gray, R. A., Roberts, E., Devinsky, O., Bazelot, M., Williams, C. M. and Stephens, G. J. (2019) Species-specific susceptibility to cannabis-induced convulsions. British Journal of Pharmacology, 176 (10). pp. 1506-1523. ISSN 0007-1188 doi: https://doi.org/10.1111/bph.14165

Cottrell, G. S., Soubrane, C. H., Hounshell, J. A., Lin, H., Owenson, V., Rigby, M., Cox, P. J., Barker, B. S., Ottolini, M., Ince, S., Bauer, C. C., Perez-Reyes, E., Patel, M. K., Stevens, E. B. and Stephens, G. J. (2018) CACHD1 is an α2δ-like protein that modulates CaV3 voltage-gated calcium channel activity. The Journal of Neuroscience, 38 (4). pp. 9186-9201. ISSN 1529-2401 doi: https://doi.org/10.1523/JNEUROSCI.3572-15.2018

Arjmand, S. , Behzadi, M., Stephens, G. J., Ezzatabadipou, S. , Seifaddini, R. , Arjmand, S. and Shabani, M. (2018) A brain on a roller coaster: can the dopamine reward system act as a protagonist to subdue the ups and downs of bipolar disorder? The Neuroscientist, 24 (5). pp. 423-439. ISSN 1073-8584 doi: https://doi.org/10.1177/1073858417714226

Coelho-Silva, L., Stephens, G. J. and Cimarosti, H. (2017) SUMOylation and calcium signalling: potential roles in the brain and beyond. Neuronal Signaling, 1 (3). NS20160010. ISSN 2059-6553 doi: https://doi.org/10.1042/NS20160010

Heath, F., Newman, A., Clementi, C., Pasut, G., Lin, H., Stephens, G. J., Whalley, B. J., Osborn, H. M. I. and Greco, F. (2016) A novel PEG–haloperidol conjugate with a non-degradable linker shows the feasibility of using polymer–drug conjugates in a non-prodrug fashion. Polymer Chemistry, 7 (47). pp. 7204-7210. ISSN 1759-9954 doi: https://doi.org/10.1039/c6py01418f

Stephens, G. J. (2016) Does modulation of the endocannabinoid system have potential therapeutic utility in cerebellar ataxia? Journal of Physiology, 594 (16). pp. 4631-4641. ISSN 1469-7793 doi: https://doi.org/10.1113/JP271106

Arjmand, S., Vaziri, Z., Behzadi, M., Abbassian, H., Stephens, G. J. and Shabani, M. (2015) Cannabinoids and tremor induced by motor-related disorders: friend or foe? Neurotherapeutics, 12 (4). pp. 778-787. ISSN 1933-7213 doi: https://doi.org/10.1007/s13311-015-0367-5

Ronzitti, G., Bucci, G., Stephens, G. and Chieregatti, E. (2015) Raft-partitioning of calcium channels regulates their function. Channels, 9 (4). pp. 169-170. ISSN 1933-6969 doi: https://doi.org/10.1080/19336950.2015.1063285

Vogl, C., Tanifuji, S., Danis, B., Daniels, V., Foerch, P., Wolff, C., Whalley, B. J., Mochida, S. and Stephens, G. J. (2015) Synaptic vesicle glycoprotein 2A modulates vesicular release and calcium channel function at peripheral sympathetic synapses. The European Journal of Neuroscience, 41 (4). pp. 398-409. ISSN 0953-816X doi: https://doi.org/10.1111/ejn.12799

Ronzitti, G., Bucci, G., Emanuele, M., Leo, D., Sotnikova, T. D., Mus, L. V., Soubrane, C. H., Dallas, M. L., Thalhammer, A., Cingolani, L. A., Mochida, S., Gainetdinov, R. R., Stephens, G. J. and Chieregatti, E. (2014) Exogenous alpha-Synuclein decreases raft partitioning of Cav2.2 channels inducing dopamine release. Journal of Neuroscience, 34 (32). pp. 10603-10615. ISSN 1529-2401 doi: https://doi.org/10.1523/JNEUROSCI.0608-14.2014

Iannotti, F. A., Hill, C. L., Leo, A., Alhusaini, A., Soubrane, C., Mazzarella, E., Russo, E., Whalley, B. J., Di Marzo, V. and Stephens, G. J. (2014) Nonpsychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability. ACS Chemical Neuroscience, 5 (11). pp. 1131-1141. ISSN 1948-7193 doi: https://doi.org/10.1021/cn5000524

Hill, A., Jones, N., Smith, I., Hill, C., Williams, C., Stephens, G. and Whalley, B. (2014) Voltage-gated sodium (NaV) channel blockade by plant cannabinoids does not confer anticonvulsant effects per se. Neuroscience Letters, 566. pp. 269-274. ISSN 0304-3940 doi: https://doi.org/10.1016/j.neulet.2014.03.013

Wang, X., Whalley, B. J. and Stephens, G. J. (2013) The du2J mouse model of ataxia and absence epilepsy has deficient cannabinoid CB1 receptor-mediated signalling. Journal of Physiology, 591 (16). pp. 3919-3933. ISSN 1469-7793 doi: https://doi.org/10.1113/jphysiol.2012.244947

Silveirinha, V., Stephens, G. J. and Cimarosti, H. (2013) Molecular targets underlying SUMO-mediated neuroprotection in brain ischemia. Journal of Neurochemistry, 127 (5). pp. 580-591. ISSN 0022-3042 doi: https://doi.org/10.1111/jnc.12347

Baillie, G. L. , Horswill, J., Anavi-Goffer,, S. , Reggio, P. H. , Bolognini , D. , Abood, M. E. , McAllister, S. , Strange, P., Stephens, G., Pertwee, R. G. and Ross, R. A. (2013) CB1 receptor allosteric modulators display both agonist and signaling pathway specificity. Molecular Pharmacology, 82 (2). pp. 322-338. ISSN 1521-0111 doi: https://doi.org/10.1124/mol.112.080879

Hill, A. J., Mercier, M. S., Hill, T. D., Glyn, S. E., Jones, N. A., Yamasaki, Y., Futamura, T., Duncan, M., Stott, C.G., Stephens, G.J., Williams, C. M. and Whalley, B.J. (2012) Cannabidivarin is anticonvulsant in mouse and rat in vitro and in seizure models. British Journal of Pharmacology, 167 (8). pp. 1629-1642. ISSN 0007-1188 doi: https://doi.org/10.1111/j.1476-5381.2012.02207.x

Jones, N. A., Glyn, S. E., Akiyama, S., Hill, T. D. M., Hill, A. J., Weston, S. E., Burnett, M. D. A., Yamasaki, Y., Stephens, G. J., Whalley, B. J. and Williams, C. M. (2012) Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures. Seizure, 21 (5). pp. 344-352. ISSN 1059-1311 doi: https://doi.org/10.1016/j.seizure.2012.03.001

Hill, A. J., Williams, C. M., Whalley, B. J. and Stephens, G. J. (2012) Phytocannabinoids as novel therapeutic agents in CNS disorders. Pharmacology & Therapeutics, 133 (1). pp. 79-97. ISSN 0163-7258 doi: https://doi.org/10.1016/j.pharmthera.2011.09.002

Vogl, C., Mochida, S., Wolff, C., Whalley, B. and Stephens, G. (2012) The SV2A ligand levetiracetam inhibits presynaptic Ca2+ channels via an intracellular pathway. Molecular Pharmacology, 82 (2). pp. 199-208. ISSN 1521-0111 doi: https://doi.org/10.1124/mol.111.076687

Bucci, G., Mochida, S. and Stephens, G. J. (2011) Inhibition of synaptic transmission and G protein modulation by synthetic CaV2.2 Ca2+ channel peptides. Journal of Physiology, 589 (13). pp. 3085-3101. ISSN 0022-3751 doi: https://doi.org/10.1113/jphysiol.2010.204735

Wang, X., Horswill, J. G., Whalley, B. J. and Stephens, G. J. (2011) Effects of the Allosteric Antagonist 1-(4-Chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea (PSNCBAM-1) on CB1 Receptor Modulation in the Cerebellum. Molecular Pharmacology, 79 (4). pp. 758-767. ISSN 1521-0111 doi: https://doi.org/10.1124/mol.110.068197

Hill, A. J., Weston, S. E., Jones, N., Smith, I., Bevan , S., Williamson, E. M., Stephens, G. J., Williams, C. M. and Whalley, B. J. (2010) Δ9-tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rat. Epilepsia, 51 (8). pp. 1522-1532. ISSN 0013-9580 doi: https://doi.org/10.1111/j.1528-1167.2010.02523.x

Jones, N. A., Hill, A. J., Smith, I., Bevan, S. A., Williams, C. M., Whalley, B. J. and Stephens, G. J. (2010) Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo. Journal of Pharmacology and Experimental Therapeutics, 332 (2). pp. 569-577. ISSN 0022-3565 doi: https://doi.org/10.1124/jpet.109.159145

Hill, A. J., Jones, N., Williams, C. M., Stephens, G. J. and Whalley, B. J. (2010) Development of multi-electrode array screening for anticonvulsants in acute rat brain slices. Journal of Neuroscience Methods, 185 (2). 246 -256 . ISSN 0165-0270 doi: https://doi.org/10.1016/j.jneumeth.2009.10.007

Yang, L. and Stephens, G. J. (2009) Effects of neuropathy on high-voltage-activated Ca2+ current in sensory neurones. Cell Calcium, 46 (4). 248-256 . ISSN 01434160 doi: https://doi.org/10.1016/j.ceca.2009.08.001

Stephens, G. J. (2009) G-protein-coupled-receptor-mediated presynaptic inhibition in the cerebellum. Trends in Pharmacological Sciences, 30 (8). 421-430 . ISSN 01656147 doi: https://doi.org/10.1016/j.tips.2009.05.008

Long, P., Mercer, A., Begum, R., Stephens, G. J., Sihra, T. and Jovanovic, J. (2009) Nerve terminal GABAA receptors activate Ca2+/calmodulin-dependent signaling to inhibit voltage-gated Ca2+ influx and glutamate release. The Journal of Biological Chemistry, 284 (13). pp. 8717-8728. ISSN 1083-351X doi: https://doi.org/10.1074/jbc.M805322200

Whalley, B. J., Stephens, G. J. and Constanti, A. (2009) Investigation of the effects of the novel anticonvulsant compound carisbamate(RWJ-333369) on rat piriform cortical neurones in vitro. British Journal of Pharmacology, 156 (6). pp. 994-1008. ISSN 0007-1188 doi: https://doi.org/10.1111/j.1476-5381.2008.00110.x

Farrimond, J., Hill, A. J., Jones, N., Stephens, G. J., Whalley, B. J. and Williams, C. M. (2009) A cost-effective high-throughput digital system for observation and acquisition of animal behavioral data. Behavior Research Methods, 41 (2). pp. 446-451. ISSN 1554-351X doi: https://doi.org/10.3758/BRM.41.2.446

Dennis, I., Whalley, B. J. and Stephens, G. J. (2008) Effects of Delta9-tetrahydrocannabivarin on [35S]GTPgammaS binding in mouse brain cerebellum and piriform cortex membranes. British Journal of Pharmacology, 154 (6). pp. 1349-58. ISSN 0007-1188 doi: https://doi.org/10.1038/bjp.2008.190

Ma, Y.-L., Weston, S.E., Whalley, B.J. and Stephens, G.J. (2008) The phytocannabinoid Δ9-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum. British Journal of Pharmacology, 154 (1). pp. 204-215. ISSN 0007-1188 doi: https://doi.org/10.1038/bjp.2008.57

Matthews, E.A., Bee, L.A., Stephens, G.J. and Dickenson, A.H. (2007) The Ca(v)2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain. European Journal of Neuroscience, 25 (12). pp. 3561-3569. ISSN 0953-816X doi: https://doi.org/10.1111/j.1460-9568.2007.05605.x

Harvey, V.L., Duguid, I.C., Krasel, C. and Stephens, G.J. (2006) Evidence that GABA rho subunits contribute to functional ionotropic GABA receptors in mouse cerebellar Purkinje cells. Journal of Physiology-London, 577 (1). pp. 127-139. ISSN 0022-3751 doi: https://doi.org/10.1113/jphysiol.2006.112482

Stephens, G.J. and Mochida, S. (2005) G protein ss gamma subunits mediate presynaptic inhibition of transmitter release from rat superior cervical ganglion neurones in culture. Journal of Physiology, 563 (3). pp. 765-776. ISSN 0022-3751 doi: https://doi.org/10.1113/jphysiol.2004.080192

Book or Report Section

Stephens, G. J. ORCID: https://orcid.org/0000-0002-8966-4238 (2023) Cannabinoids. In: Gruol, D. L., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J. D. and Shen, Y. (eds.) Essentials of Cerebellum and Cerebellar Disorders. A Primer for Graduate Students. 2nd edition. Springer, pp. 221-224. ISBN 9783031150692 doi: https://doi.org/10.1007/978-3-031-15070-8_34

Barker, B. S. , Young , G. T. , Soubrane, C. H., Stephens, G. J., Stevens, E. B. and Patel , M. K. (2017) Ion channels. In: Conn, P. M. (ed.) Conn's Translational Neuroscience 1st Edition. Elsevier Academic Press, London, pp. 11-43. ISBN 9780128023815 doi: https://doi.org/10.1016/B978-0-12-802381-5.00002-6

Stephens, G. J. (2016) Cerebellar circuits: biochemistry, neurotransmitters and neuromodulators: cannabinoids as modulators in the cerebellum. In: Gruol, D. L., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J. D. and Shen, Y. (eds.) Essentials of Cerebellum and Cerebellar Disorders: A Primer For Graduate Students. Springer, Dordrecht, pp. 255-259. ISBN 9783319245492 doi: https://doi.org/10.1007/978-3-319-24551-5_33

Bucci, G., Mochida, S. and Stephens, G. (2013) Use of synthetic CaV2.2 Ca2+ channel peptides to study presynaptic function. In: Stephens, G. and Mochida, S. (eds.) Modulation of Presynaptic Calcium Channels. Springer, Dordrecht, pp. 223-240. ISBN 9789400763333 doi: https://doi.org/10.1007/978-94-007-6334-0

Conference or Workshop Item

Weston, S. E., Williamson, E. M., Constanti, A., Stephens, G. J. and Whalley, B. J. (2006) Tetrahydrocannabivarin exhibits anticonvulsant effects in a piriform cortical brain slice model of epileptiform activity. In: British Pharmacological Society Winter Meeting 2006.

Book

Stevens, E. B. and Stephens, G. J., eds. (2018) Recent advances in targeting ion channels to treat chronic pain. British Journal of Pharmacology, 175 (12). Wiley, pp. 2133-2137. doi: https://doi.org/10.1111/bph.14215