Number of items: 40.
Article
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Amadi, S. U., Smith, S. J. and Sugden, P. H.
(2024)
Inhibiting the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade in cancer and the heart: for better or worse, in sickness and health?
International Journal of Drug Discovery and Pharmacology.
ISSN 2653-6234
doi: https://doi.org/10.53941/ijddp.2024.100006
Cull, J. J., Cooper, S. T. E., Alharbi, H. O., Chothani, S. P., Rackham, O. J. L., Meijles, D., Dash, P. R., Kerkelä, R., Ruparelia, N., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2024)
Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice in vivo.
Clinical Science, 138 (10).
pp. 573-597.
ISSN 1470-8736
doi: https://doi.org/10.1042/CS20240496
Alharbi, H. O., Hardyman, M. A., Cull, J. J., Markou, T., Cooper, S. T. E., Glennon, P. E., Fuller, S. J., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2022)
Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice.
Clinical Science, 136 (22).
pp. 1661-1681.
ISSN 0143-5221
doi: https://doi.org/10.1042/CS20220607
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Meijles, D. N., Hardyman, M. A., Fuller, S. J., Chothani, S. P., Cull, J. J., Cooper, S. T. E., Alharbi, H. O., Vanezis, K., Felkin, L. E., Markou, T., Leonard, S. J., Shaw, S. W., Rackham, O. J. L., Cook, S. A., Glennon, P. E., Sheppard, M. N., Sembrat, J. C., Rojas, M., McTiernan, C. F., Barton, P. J. and Sugden, P. H.
(2022)
Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo.
Biochemical Journal, 479 (3).
pp. 401-424.
ISSN 0264-6021
doi: https://doi.org/10.1042/BCJ20210615
Meijles, D. N., Cull, J. J., Cooper, S. T. E., Markou, T., Hardyman, M. A., Fuller, S. J., Alharbi, H. O., Haines, Z. H. R., Alcantara Alonso, V.
ORCID: https://orcid.org/0000-0002-9782-2398, Glennon, P. E., Sheppard, M. N., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2021)
The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension.
Clinical Science, 135 (14).
pp. 1631-1647.
ISSN 0143-5221
doi: https://doi.org/10.1042/CS20210192
Meijles, D. N., Fuller, S. J., Cull, J. J., Alharbi, H. O., Cooper, S. T. E., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2021)
The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α1-adrenergic receptors.
Biochemical Journal, 478 (11).
pp. 2059-2079.
ISSN 1470-8728
doi: https://doi.org/10.1042/BCJ20210144
Fuller, S. J., Edmunds, N. S., McGuffin, L. J.
ORCID: https://orcid.org/0000-0003-4501-4767, Hardyman, M. A., Cull, J. J., Alharbi, H. O., Meijles, D. N., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2021)
MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins.
Biochemical Journal, 478 (11).
pp. 2121-2143.
ISSN 0264-6021
doi: https://doi.org/10.1042/BCJ20210003
Meijles, D. N., Cull, J. J., Markou, T., Cooper, S. T. E., Haines, Z. H. R., Fuller, S. J., O'Gara, P., Sheppard, M. N., Harding, S. E., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2020)
Redox regulation of cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) controls p38-MAPK (Mitogen-Activated Protein Kinase) and orchestrates cardiac remodelling to hypertension.
Hypertension, 76 (4).
pp. 1208-1218.
ISSN 1524-4563
doi: https://doi.org/10.1161/HYPERTENSIONAHA.119.14556
Meijles, D. N., Zoumpoulidou, G., Markou, T., Rostron, K. A., Patel, R., Lay, K., Handa, B. S., Wong, B., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2019)
The cardiomyocyte "redox rheostat": Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death.
Journal of molecular and cellular cardiology, 129.
pp. 118-129.
ISSN 1095-8584
doi: https://doi.org/10.1016/j.yjmcc.2019.02.006
Fuller, S. J., Osborne, S. A., Leonard, S. J., Hardyman, M. A., Vaniotis, G., Allen, B. G., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2015)
Cardiac protein kinases: the cardiomyocyte kinome and differential kinase expression in human failing hearts.
Cardiovascular Research, 108 (1).
pp. 87-98.
ISSN 0008-6363
doi: https://doi.org/10.1093/cvr/cvv210
Sugden, P. H., McGuffin, L. J.
ORCID: https://orcid.org/0000-0003-4501-4767 and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2013)
SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein–protein interactions.
Biochemical Journal, 454 (1).
pp. 13-30.
ISSN 0264-6021
doi: https://doi.org/10.1042/BJ20130219
Barrett, O. P. T., Yndestad, A., Marshall, A. K., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2013)
The early transcriptomic response to interleukin 1β and interleukin 33 in rat neonatal cardiomyocytes.
Cytokine, 61 (2).
pp. 340-344.
ISSN 1096-0023
doi: https://doi.org/10.1016/j.cyto.2012.11.004
Amirak, E., Fuller, S. J., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2013)
p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to Gq protein-coupled receptor stimuli, endothelin-1 and α1-adrenergic receptor agonists.
Biochemical Journal, 450 (2).
pp. 351-363.
ISSN 0264-6021
doi: https://doi.org/10.1042/BJ20121371
Giraldo, A., Barrett, O. P. T., Tindall, M. J., Fuller, S. J., Amirak, E., Bhattacharya, B. S., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2012)
Feedback regulation by Atf3 in the endothelin-1-responsive transcriptome of cardiomyocytes: Egr1 is a principal Atf3 target.
Biochemical Journal, 444 (2).
pp. 343-355.
ISSN 0264-6021
doi: https://doi.org/10.1042/BJ20120125
Fuller, S. J., McGuffin, L. J.
ORCID: https://orcid.org/0000-0003-4501-4767, Marshall, A. K., Giraldo, A., Pikkarainen, S., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P.
(2012)
A novel, non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3).
Biochemical Journal, 442 (3).
pp. 595-610.
ISSN 0264-6021
doi: https://doi.org/10.1042/BJ20112000
Zhou, Y., Adolfs, Y., Pijnappel, W. W. M. P., Fuller, S. J., Van der Schors, R. C., Li, K. W., Sugden, P. H., Smit, A. B., Hergovich, A. and Pasterkamp, R. J.
(2011)
MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis.
Molecular and cellular biology, 31 (17).
pp. 3603-3615.
ISSN 1098-5549
doi: https://doi.org/10.1128/MCB.01389-10
Korf-Klingebiel, M., Kempf, T., Schlüter, K.-D., Willenbockel, C., Brod, T., Heineke, J., Schmidt, V. J., Jantzen, F., Brandes, R. P., Sugden, P. H., Drexler, H., Molkentin, J. D. and Wollert, K. C.
(2011)
Conditional transgenic expression of fibroblast growth factor 9 in the adult mouse heart reduces heart failure mortality after myocardial infarction.
Circulation, 123 (5).
pp. 504-14.
ISSN 1524-4539
doi: https://doi.org/10.1161/CIRCULATIONAHA.110.989665
Sugden, P. H., Markou, T., Fuller, S. J., Tham, E. L., Molkentin, J. D., Paterson, H. F. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2011)
Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active.
Cellular Signalling, 23 (2).
pp. 468-477.
ISSN 0898-6568
doi: https://doi.org/10.1016/j.cellsig.2010.10.024
Marshall, A. K., Barrett, O. P. T., Cullingford, T. E., Shanmugasundram, A., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2010)
ERK1/2 signaling dominates over RhoA signaling in regulating early changes in RNA expression induced by endothelin-1 in neonatal rat cardiomyocytes.
PLoS ONE, 5 (4).
e10027.
ISSN 1932-6203
doi: https://doi.org/10.1371/journal.pone.0010027
Yndestad, A., Marshall, A. K., Hodgkinson, J. D., Tham, E. L., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2010)
Modulation of interleukin signalling and gene expression in cardiac myocytes by endothelin-1.
International Journal of Biochemistry & Cell Biology, 42 (2).
pp. 263-272.
ISSN 1357-2725
doi: https://doi.org/10.1016/j.biocel.2009.10.021
Markou, T., Marshall, A. K., Cullingford, T. E., Tham, E. L., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2010)
Regulation of the cardiomyocyte transcriptome vs translatome by endothelin-1 and insulin: translational regulation of 5' terminal oligopyrimidine tract (TOP) mRNAs by insulin.
BMC Genomics, 11.
343.
ISSN 1471-2164
doi: https://doi.org/10.1186/1471-2164-11-343
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Cullingford, T. E., Fuller, S. J., Giraldo, A. and Sugden, P. H.
(2009)
Endothelin-1 regulation of immediate early gene expression in cardiac myocytes: negative feedback regulation of interleukin 6 by Atf3 and Klf2.
Advances in Enzyme Regulation, 49 (1).
pp. 30-42.
ISSN 0065-2571
doi: https://doi.org/10.1016/j.advenzreg.2008.12.007
Pikkarainen, S., Kennedy, R. A., Marshall, A. K., Tham, E. L., Lay, K., Kriz, T. A., Handa, B. S., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(2009)
Regulation of expression of the rat orthologue of mouse double minute 2 (MDM2) by H2O2-induced oxidative stress in neonatal rat cardiac myocytes.
The Journal of Biological Chemistry, 284 (40).
pp. 27195-27210.
ISSN 1083-351X
doi: https://doi.org/10.1074/jbc.M109.037887
Cook, S. A., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(2008)
Are transgenic mice the 'alkahest' to understanding myocardial hypertrophy and failure?
Journal of Molecular and Cellular Cardiology, 46 (2).
pp. 118-129.
ISSN 0022-2828
doi: https://doi.org/10.1016/j.yjmcc.2008.11.005
Cullingford, T. E., Butler, M. J., Marshall, A. K., Tham, E. L., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2008)
Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines.
Biochimica Et Biophysica Acta-Molecular Cell Research, 1783 (6).
pp. 1229-1236.
ISSN 0167-4889
doi: https://doi.org/10.1016/j.bbamcr.2008.03.007
Sugden, P. H., Fuller, S. J., Weiss, S. C. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2008)
Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis.
British Journal of Pharmacology, 153 (S1).
S137-S153.
ISSN 1476-5381
doi: https://doi.org/10.1038/sj.bjp.0707659
Markou, T., Cullingford, T. E., Giraldo Ramirez, A., Weiss, S. C., Alsafi, A., Fuller, S. J., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(2008)
Glycogen synthase kinases 3α and 3β in cardiac myocytes: regulation and consequences of their inhibition.
Cellular Signalling, 20 (1).
pp. 206-218.
ISSN 0898-6568
doi: https://doi.org/10.1016/j.cellsig.2007.10.004
Fuller, S. J., Pikkarainen, S., Tham, E. L., Cullingford, T. E., Molkentin, J. D., Cornils, H., Hergovitch, A., Hemmings, B. A., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(2008)
Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors.
Cellular Signalling, 20 (8).
pp. 1564-1577.
ISSN 0898-6568
doi: https://doi.org/10.1016/j.cellsig.2008.04.013
Cullingford, T. E., Markou, T., Fuller, S. J., Giraldo, A., Pikkarainern, S., Zoumpoulidou, G., Alsafi, A., Ekere, C., Kemp, T. J., Dennis, J. L., Game, L., Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2008)
Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes.
Genome Biology, 9 (2).
R32.
ISSN 1474-760X
doi: https://doi.org/10.1186/gb-2008-9-2-r32
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Cullingford, T. E., Fuller, S. J., Giraldo, A., Markou, T., Pikkarainen, S. and Sugden, P.
(2007)
Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses.
Journal of cellular physiology, 212 (2).
pp. 311-322.
ISSN 0021-9541
doi: https://doi.org/10.1002/jcp.21094
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Kemp, T. J., Zoumpoulidou, G. and Sugden, P.
(2007)
Cardiac myocyte gene expression profiling during H2O2-induced apoptosis.
Physiological genomics, 29 (2).
pp. 118-127.
ISSN 1531-2267
doi: https://doi.org/10.1152/physiolgenomics.00168.2006
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Giraldo, A. and Sugden, P.
(2007)
Chemotherapeutic agents and gene expression in cardiac myocytes.
Advances in Enzyme Regulation, 47 (1).
pp. 140-153.
ISSN 0065-2571
doi: https://doi.org/10.1016/j.advenzreg.2006.12.004
Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2006)
Oxidative stress and growth-regulating intracellular signaling pathways in cardiac myocytes.
Antioxidants & Redox Signaling, 8 (11-12).
pp. 2111-2124.
ISSN 1523-0864
doi: https://doi.org/10.1089/ars.2006.8.2111
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P.
(2006)
Ras: the stress and the strain.
Journal of Molecular and Cellular Cardiology, 41 (4).
pp. 595-600.
ISSN 0022-2828
doi: https://doi.org/10.1016/j.yjmcc.2006.06.075
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P.
(2006)
Inflame my heart (by p38-MAPK).
Circulation Research, 99 (5).
pp. 455-458.
ISSN 0009-7330
doi: https://doi.org/10.1161/01.RES.0000241053.89089.c3
Kennedy, R. A., Kemp, T. J., Sugden, P. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2006)
Using U0126 to dissect the role of the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade in the regulation of gene expression by endothelin-1 in cardiac myocytes.
Journal of Molecular and Cellular Cardiology, 41 (2).
pp. 236-247.
ISSN 0022-2828
doi: https://doi.org/10.1016/j.yjmcc.2006.04.011
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Aggeli, I.-K. S., Stathopoulou, K. and Sugden, P. H.
(2006)
Peptide growth factors signal differentially through protein kinase C to extracellular signal-regulated kinases in neonatal cardiomyocytes.
Cellular Signalling, 18 (2).
pp. 225-235.
ISSN 0898-6568
doi: https://doi.org/10.1016/j.cellsig.2005.04.005
Cullingford, T. E., Wait, R., Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H.
(2006)
Effects of oxidative stress on the cardiac myocyte proteome: modifications to peroxiredoxins and small heat shock proteins.
Journal of Molecular and Cellular Cardiology, 40 (1).
pp. 157-172.
ISSN 0022-2828
doi: https://doi.org/10.1016/j.yjmcc.2005.10.004
Sugden, P. H. and Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708
(2005)
Endothelin signalling in the cardiac myocyte and its pathophysiological relevance.
Current vascular pharmacology, 3 (4).
pp. 343-351.
ISSN 1570-1611
doi: https://doi.org/10.2174/157016105774329390
Clerk, A.
ORCID: https://orcid.org/0000-0002-5658-0708, Cullingford, T. E., Kemp, T. J., Kennedy, R. A. and Sugden, P. H.
(2005)
Regulation of gene and protein expression in cardiac myocyte hypertrophy and apoptosis.
Advances in Enzyme Regulation, 45 (1).
pp. 94-111.
ISSN 0065-2571
doi: https://doi.org/10.1016/j.advenzreg.2005.02.007
This list was generated on Fri Aug 16 21:18:27 2024 UTC.