Article

Mitchell, Joanne L., Dunster, Joanne L., Kriek, Neline, Unsworth, Amanda J., Sage, Tanya, Mohammed, Yasmin M. M., De Simone, Ilaria, Taylor, Kirk A., Bye, Alexander P. ORCID: https://orcid.org/0000-0002-2061-2253, Ólafsson, Geir, Brunton, Mark, Mark, Sharon, Dymott, Leanne D., Whyte, Abigail, Ruparelia, Neil, Mckenna, Charlie, Gibbins, Jonathan M. ORCID: https://orcid.org/0000-0002-0372-5352 and Jones, Christopher I. ORCID: https://orcid.org/0000-0001-7537-1509 (2023) The rate of platelet activation determines thrombus size and structure at arterial shear. Journal of Thrombosis and Haemostasis, 21 (8). pp. 2248-2259. ISSN 1538-7836 doi: https://doi.org/10.1016/j.jtha.2023.03.044

Kuravi, Sahithi J., Ahmed, Niaz S., Taylor, Kirk A., Capes, Emily M., Bye, Alex, Unsworth, Amanda J., Gibbins, Jonathan M. and Pugh, Nicholas (2023) Delineating zinc influx mechanisms during platelet activation. International Journal of Molecular Sciences, 24 (14). 11689. ISSN 1422-0067 doi: https://doi.org/10.3390/ijms241411689

Mitchell, Joanne L., Little, Gemma, Bye, Alexander P. ORCID: https://orcid.org/0000-0002-2061-2253, Gaspar, Renato S., Unsworth, Amanda J., Kriek, Neline, Sage, Tanya, Stainer, Alexander, Sangowawa, Ibidayo, Morrow, Gael B., Bastos, Ricardo N., Shapiro, Susan, Desborough, Michael J. R., Curry, Nicola, Gibbins, Jonathan M. ORCID: https://orcid.org/0000-0002-0372-5352, Whyte, Claire S., Mutch, Nicola J. and Jones, Christopher I. ORCID: https://orcid.org/0000-0001-7537-1509 (2023) Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability. Research and Practice in Thrombosis and Haemostasis, 7 (5). 100200. ISSN 2475-0379 doi: https://doi.org/10.1016/j.rpth.2023.100200

Kriek, Neline, Nock, Sophie H., Sage, Tanya, Khalifa, Badrija, Bye, Alexander P. ORCID: https://orcid.org/0000-0002-2061-2253, Mitchell, Joanne L., Thomson, Steven, McLaughlin, Mark G., Jones, Sarah, Gibbins, Jonathan M. ORCID: https://orcid.org/0000-0002-0372-5352 and Unsworth, Amanda J. ORCID: https://orcid.org/0000-0003-3809-5984 (2022) Cucurbitacins elicit anti-platelet activity via perturbation of the cytoskeleton and integrin function. Thrombosis and Haemostasis, 122 (07). pp. 1115-1129. ISSN 0340-6245 doi: https://doi.org/10.1055/a-1788-5322

Dunster, Joanne, Bye, Alex, Kriek, Neline, Sage, Tanya, Mitchell, Joanne, Kempster, Carly, Batista, Joana, KcKinney, Harriet, Thomas, Patrick, Jones, Chris ORCID: https://orcid.org/0000-0001-7537-1509, Downes, Kate, Unsworth, Amanda and Gibbins, Jon ORCID: https://orcid.org/0000-0002-0372-5352 (2021) Multi-parameter phenotyping of platelet reactivity for stratification of human cohorts. Blood Advances, 5 (20). pp. 4017-4030. ISSN 2473-9529 doi: https://doi.org/10.1182/bloodadvances.2020003261

Unsworth, Amanda J., Bye, Alexander P., Sage, Tanya, Gaspar, Renato S., Eaton, Nathan, Drew, Caleb, Stainer, Alexander, Kriek, Neline, Volberding, Peter J., Hutchinson, James L., Riley, Ryan, Jones, Sarah, Mundell, Stuart J., Cui, Weiguo, Falet, Hervé and Gibbins, Jonathan M. (2021) Anti-platelet properties of Pim kinase inhibition is mediated through disruption of thromboxane A2 receptor signalling. Haematologica, 106 (7). ISSN 1592-8721 doi: https://doi.org/10.3324/haematol.2019.223529

Sahli, Khaled A., Flora, Gagan D., Sasikumar, Parvathy, Maghrabi, Ali H, Holbrook, Lisa, AlOuda, Sarah K, Elgheznawy, Amro, Sage, Tanya, Stainer, Alex R., Adiyaman, Recep, AboHassan, Mohammad, Crescente, Marilena, Kriek, Neline, Vaiyapuri, Sakthi, Bye, Alex P., Unsworth, Amanda J., Jones, Chris I., McGuffin, Liam J. and Gibbins, Jon M. (2021) Structural, functional and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets. Blood, 137 (6). pp. 830-843. ISSN 0006-4971 doi: https://doi.org/10.1182/blood.2019004575

Dunster, Joanne L., Unsworth, Amanda J., Bye, Alexander P., Haining, Elizabeth J,, Sowa, Marcin A., Di, Ying, Sage, Tanya, Pallini, Chiara, Pike, Jeremy A., Hardy, Alexander T., Nieswandt, Bernhard, García, Ángel, Watson, Steve P., Poulter, Natalie S., Gibbins, Jonathan M. and Pollitt, Alice Y. (2020) Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation. Journal of Thrombosis and Haemostasis, 18 (2). pp. 485-496. ISSN 1538-7836 doi: https://doi.org/10.1111/jth.14673

Flora, Gagan D., Sahli, Khaled A., Sasikumar, Parvathy, Holbrook, Lisa-Marie, Stainer, Alex R., Alouda, Sarah K., Crescente, Marilena, Sage, Tanya, Unsworth, Amanda J. and Gibbins, Jon M. (2019) Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis. Scientific Reports, 9 (1). 17210. ISSN 2045-2322 doi: https://doi.org/10.1038/s41598-019-53218-x

Stainer, Alex, Sasikumar, Parvathy, Bye, Alex, Unsworth, Amanda, Holbrook, Lisa, Tindall, Marcus, Lovegrove, Julie and Gibbins, Jon (2019) Quercetin and its methylated metabolites possess anti-thrombotic properties that interact with aspirin to enhance its anti-platelet effects. TH Open, 3 (3). e244-e258. ISSN 2512-9465 doi: https://doi.org/10.1055/s-0039-1694028

Unsworth, Amanda J., Bombik, I., Pinto-Fernandez, A., McGouran, J. F., Konietzny, R., Zahedi, R. P., Watson, S. P., Kessler, B. M. and Pears, C. J. (2019) Human platelet protein ubiquitylation and changes following GPVI activation. Thrombosis and Haemostasis, 119 (1). pp. 104-116. ISSN 0340-6245 doi: https://doi.org/10.1055/s-0038-1676344

Unsworth, Amanda J., Bye, Alex P., Kriek, Neline, Sage, Tanya, Osborne, Ashley A., Donaghy, Dillon and Gibbins, Jonathan M. (2019) Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction. Platelets, 30 (6). pp. 762-772. ISSN 0953-7104 doi: https://doi.org/10.1080/09537104.2018.1514107

Stainer, Alexander R., Sasikumar, Parvathy, Bye, Alexander P., Unsworth, Amanda P., Holbrook, Lisa M., Tindall, Marcus, Lovegrove, Julie A. and Gibbins, Jonathan M. (2019) The metabolites of the dietary flavonoid quercetin possess potent antithrombotic activity, and interact with aspirin to enhance antiplatelet effects. TH Open, 3 (3). e244-e258. ISSN 2512-9465 doi: https://doi.org/10.1055/s-0039-1694028

Sasikumar, P., AlOuda, K. S., Kaiser, W. J., Holbrook, L. M., Kriek, N., Unsworth, A. J., Bye, A. P., Sage, T., Ushioda, R. W., Nagata, K., Farndale, R. W. and Gibbins, J. M. (2018) The chaperone protein HSP47: a platelet collagen binding protein that contributes to thrombosis and haemostasis. Journal of Thrombosis and Haemostasis, 16 (5). pp. 946-959. ISSN 1538-7933 doi: https://doi.org/10.1111/jth.13998

Unsworth, Amanda J., Flora, Gagan D. and Gibbins, Jon M. (2018) Non-genomic effects of nuclear receptors: insights from the anucleate platelet. Cardiovascular Research, 114 (5). pp. 645-655. ISSN 0008-6363 doi: https://doi.org/10.1093/cvr/cvy044

Bye, Alex P., Unsworth, Amanda J., Desborough, Michael J., Hildyard, Catherine A. T., Appleby, Niamh, Bruce, David, Kriek, Neline, Nock, Sophie H., Sage, Tanya, Hughes, Craig E. and Gibbins, Jon M. (2017) Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib. Blood Advances, 1 (26). pp. 2610-2623. ISSN 2473-9529 doi: https://doi.org/10.1182/bloodadvances.2017011999

Unsworth, Amanda J., Bye, Alexander P., Tannetta, Dionne S., Desborough, Michael J. R., Kriek, Neline, Sage, Tanya, Allan, Harriet E., Crescente, Marilena, Yaqoob, Parveen, Warner, Timothy D., Jones, Chris I. and Gibbins, Jon M. (2017) Farnesoid X receptor and liver X receptor ligands initiate formation of coated platelets. Arteriosclerosis, thrombosis, and vascular biology, 37 (8). pp. 1482-1493. ISSN 1524-4636 doi: https://doi.org/10.1161/ATVBAHA.117.309135

Unsworth, Amanda J., Flora, Gagan D., Sasikumar, Parvathy, Bye, Alexander P., Sage, Tanya, Kriek, Neline, Crescente, Marilena and Gibbins, Jonathan M. (2017) RXR ligands negatively regulate thrombosis and hemostasis. Arteriosclerosis Thrombosis and Vascular Biology, 37 (5). pp. 812-822. ISSN 1524-4636 doi: https://doi.org/10.1161/ATVBAHA.117.309207

Unsworth, A. J., Kriek, N., Bye, A. P., Naran, K., Sage, T., Flora, G. D. and Gibbins, J. M. (2017) PPARγ agonists negatively regulate αIIbβ3 integrin outside-in signalling and platelet function through upregulation of protein kinase A activity. Journal of Thrombosis and Haemostasis, 15 (2). pp. 356-369. ISSN 1538-7933 doi: https://doi.org/10.1111/jth.13578

Moraes, Leonardo A., Unsworth, Amanda J., Vaiyapuri, Sakthivel, Ali, Marfoua S., Sasikumar, Parvathy, Sage, Tanya, Flora, Gagan D., Bye, Alex P., Kriek, Neline, Dorchies, Emilie, Molendi-Coste, Olivier, Dombrowicz, David, Staels, Bart, Bishop-Bailey, David and Gibbins, Jonathan M. (2016) Farnesoid X Receptor and its ligands inhibit the function of platelets. Arteriosclerosis Thrombosis and Vascular Biology, 36 (12). pp. 2324-2333. ISSN 1524-4636 doi: https://doi.org/10.1161/ATVBAHA.116.308093

Bye, Alex P., Unsworth, Amanda J. and Gibbins, Jon M. (2016) Platelet signaling: a complex interplay between inhibitory and activatory networks. Journal of Thrombosis and Haemostasis, 14 (5). pp. 918-930. ISSN 1538-7933 doi: https://doi.org/10.1111/jth.13302

Bye, Alex P., Unsworth, Amanda J., Vaiyapuri, Sakthi, Stainer, Alexander R., Fry, Mike J. and Gibbins, Jon M. (2015) Ibrutinib inhibits platelet integrin αIIbβ3 outside-in signaling and thrombus stability but not adhesion to collagen. Arteriosclerosis Thrombosis and Vascular Biology, 35 (11). pp. 2326-2335. ISSN 1524-4636 doi: https://doi.org/10.1161/ATVBAHA.115.306130

Vaiyapuri, Sakthivel, Roweth, Harvey, Ali, Marfoua, Unsworth, Amanda, Stainer, Alexander, Flora, Gagan, Crescente, Marilena, Jones, Chris, Moraes, Leo and Gibbins, Jon (2015) Pharmacological actions of nobiletin in the modulation of platelet function. British Journal of Pharmacology, 172 (16). pp. 4133-4145. ISSN 0007-1188 doi: https://doi.org/10.1111/bph.13191

Vaiyapuri, Sakthivel, Sage, Tanya, Rana, Rekha H., Schenk, Michael P., Ali, Marfoua S., Unsworth, Amanda J., Jones, Chris I., Stainer, Alexander R., Kriek, Neline Kriek, Moraes, Leonardo A. and Gibbins, Jonathan (2015) EphB2 regulates contact-dependent and independent signalling to control platelet function. Blood, 125 (4). pp. 720-730. ISSN 0006-4971 doi: https://doi.org/10.1182/blood-2014-06-585083

Book or Report Section

Bye, Alex, Ilkan, Zeki, Unsworth, Amanda and Jones, Chris (2018) Immobilization of nonactivated unfixed platelets for real-time single-cell analysis. In: Gibbins, Jon and Mahaut-Smith, Martyn (eds.) Platelets and Megakaryocytes (Volume 4, Advanced Protocols and Perspectives). Methods in Molecular Biology, 1812. Springer Protocols, pp. 1-11. ISBN 9781493985845

Bye, Alexander P., Unsworth, Amanda J. and Gibbins, Jonathan M. (2018) Screening and high-throughput platelet assays. In: Gibbins, Jonathan M. and Mahaut-Smith, Martyn (eds.) Platelets and Megakaryocytes: Volume 4, Advanced Protocols and Perspectives. Humana Press, New York, pp. 81-94. ISBN 9781493985845 doi: https://doi.org/10.1007/978-1-4939-8585-2_5