2022

Clavere, N. G., Alqallaf, A., Rostron, K. A., Parnell, A., Mitchell, R., Patel, K. and Boateng, S. Y. (2022) Inhibition of activin A receptor signalling attenuates age-related pathological cardiac remodelling. Disease Models & Mechanisms, 15 (5). dmm049424. ISSN 1754-8411 doi: https://doi.org/10.1242/dmm.049424

2021

Suarez-Berumen, K., Collins-Hooper, H., Gormova, A., Meech, R., Sacco, A., Dash, P., Mitchell, R., Shestopalov, V., Woolley, T., Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517, Patel, K. and Makarenkova, H. (2021) Pannexin 1 regulates skeletal muscle regeneration by promoting bleb-based myoblast migration and fusion through a novel lipid based signaling mechanism. Frontiers in Cell and Developmental Biology, 9. 736813. ISSN 2296-634X doi: https://doi.org/10.3389/fcell.2021.736813

Ahmad, F., Mitchell, R., Houben, T., Palo, A., Yasdati, T., Parnell, A., Patel, K., Shiri-Sverdlov, R. and Leake, D. ORCID: https://orcid.org/0000-0002-1742-6134 (2021) Cysteamine decreases low density lipoprotein oxidation, causes regression of atherosclerosis and improves liver and muscle function in LDL receptor deficient mice. JAHA: Journal of the American Heart Association, 10 (18). ISSN 2047-9980 doi: https://doi.org/10.1161/JAHA.120.017524

solagna, f., Tezze, c., Lindenmeyer, M., Lu, S., Wu, G., Liu, S., Zhao, Y., Mitchell, R., Mayer, C., Omairi, S., Kilic, t., Paolini, A., Ritvos, O., Pasternak, A., Kylies, D., Wiesch, J., Turner, J.-E., Wanner, N., Nair, V., Eichinger, F., Menon, R., Martin, I., Klinkhammer, B., Hoxha, E., Cohen, C., Tharaux, P.-L., Boor, P., Ostendorf, T., Kretzler, M., Sandri, M., Kretz, O., Puelles, V., Patel, K. and Huber, T. (2021) Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs. Journal of Clinical Investigation, 131 (11). e135821. ISSN 0021-9738 doi: https://doi.org/10.1172/JCI135821

Barlow, J., Sfyri, P. P., Mitchell, R., Verpoorten, S., Scully, D., Andreeou, C., Papadopoulos, P., Patel, K. and Matsakas, A. (2021) Platelet releasate normalises the compromised muscle regeneration in a mouse model of hyperlipidaemia. Experimental Physiology, 106 (3). pp. 700-713. ISSN 0958-0670 doi: https://doi.org/10.1113/EP088937

Vaughan, D., Mitchell, R., Kretz, O., Chambers, D., Lalowski, M., Amthor, H., Ritvos, O., Pasternack, A., Matsakas, A., Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517, Huber, T. B., Denecke, B., Mukherjee, A., Widera, D. ORCID: https://orcid.org/0000-0003-1686-130X and Patel, K. (2021) A muscle growth promoting treatment based on the attenuation of activin/myostatin signalling in young mice results in long-term testicular abnormalities. Disease Models & Mechanisms, 14 (2). ISSN 1754-8411 doi: https://doi.org/10.1242/dmm.047555

Antounians, L., Catania, V. D., Montalva, L., Liu, B. D., Hou, H., Chan, C., Matie, A. C., Tzabetakis, A., Li, B., Figueira, R. L., da Costa, K. M., Wong, A. P., Mitchell, R., David, A. L., Patel, K., de Coppi, P., Sbragia, L., Wilson, M. D., Rossant, J. and Zani, A. (2021) Fetal lung underdevelopment is rescued by administration of amniotic fluid stem cell extracellular vesicles in rodents. Science Translational Medicine, 13 (590). eaax5941. ISSN 1946-6234 doi: https://doi.org/10.1126/scitranslmed.aax5941

2020

Vaughan, D., Kretz, O., Alqallaf, A., Mitchell, R., Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517, Matsakas, A., Pasternack, A., Collins-Hooper, H., Ritvos, O., Ballesteros, R., Huber, T. B., Amthor, H., Mukherjee, A. and Patel, K. (2020) Diminution in sperm quantity and quality in mouse models of Duchenne Muscular Dystrophy induced by a myostatin-based muscle growth-promoting intervention. European Journal of Translational Myology, 30 (2). pp. 276-285. ISSN 2037-7452 doi: https://doi.org/10.4081/ejtm.2019.8904

Verpoorten, S., Sfryi, P., Scully, D., Mitchell, R., Tzimou, A., Mougious, V., Patel, K. and Matsakas, A. (2020) Loss of CD36 protects against diet-induced obesity but results in impaired muscle stem cell function, delayed muscle regeneration and hepatic steatosis. Acta Physiologica, 228 (3). e13395. ISSN 1748-1716 doi: https://doi.org/10.1111/apha.13395

2019

Scully, D., Sfyri, P., Verpooten, S., Papadopoulos, P., Muñoz-Turrillas, M. C., Mitchell, R., Aburima, A., Patel, K., Gutierez, l., Naseem, K. M. and Matsakas, A. (2019) Platelet releasate promotes skeletal myogenesis by increasing muscle stem cell commitment to differentiation and accelerates muscle regeneration following acute injury. Acta Physiologica, 225 (3). e13207. ISSN 1748-1708 doi: https://doi.org/10.1111/apha.13207

Williams, H., Mellows, B., Mitchell, R., Sfyri, P., Layfield, H., Salamah, M., Vaiyapuri, R., Collins-Hooper, H., Bicknell, A., Matsakas, A., Patel, K. and Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517 (2019) Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease. PLoS Neglected Tropical Diseases, 13 (1). e0007041. ISSN 1935-2735 doi: https://doi.org/10.1371/journal.pntd.0007041

Alyodawi, K., Vermeij, W. P., Omairi, S., kretz, O., Hopkinson, M., Solagna, F., Joch, B., Brandt, R. M. C., Barnhoorn, S., van Vliet, N., Ridwan, Y., Essers, J., Mitchell, R., Morash, T., Pasternack, A., Ritvos, O., Matsakas, A., Collins-Hooper, H., Huber, T. B., Hoeijmakers, J. H. J. and Patel, K. (2019) Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling. Journal of Cachexia, Sarcopenia and Muscle, 10 (3). pp. 662-686. ISSN 2190-6009 doi: https://doi.org/10.1002/jcsm.12404

Mitchell, R., Mellows, B., Sheard, J., Antonioli, M., Kretz, O., Chambers, D., Zeuner, M.-T., Tomkins, J. E., Denecke, B., Musante, L., Joch, B., Debacq-Chainiaux, F., Holthofer, H., Ray, S., Huber, T. B., Dengjel, J., De Coppi, P., Widera, D. ORCID: https://orcid.org/0000-0003-1686-130X and Patel, K. (2019) Secretome of adipose-derived mesenchymal stem cells promotes skeletal muscle regeneration through synergistic action of extracellular vesicle cargo and soluble proteins. Stem Cell Research and Therapy, 10. 116. ISSN 1757-6512 doi: https://doi.org/10.1186/s13287-019-1213-1

2018

Paolini, A., Omairi, S., Mitchell, R., Vaughan, D., Matsakas, A., Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517, Ricketts, T., Rubinsztein, D. C. and Patel, K. (2018) Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury. Scientific Reports, 8. 9062. ISSN 2045-2322 doi: https://doi.org/10.1038/s41598-018-27429-7

Maden, M., Brant, J. O., Rubiano, A., Sandova, A. G. W., Simmons, C., Mitchell, R., Collins-Hooper, H., Jacobson, J., Omairi, S. and Patel, K. (2018) Perfect chronic skeletal muscle regeneration in adult spiny mice, Acomys cahirinus. Scientific Reports, 8 (1). 8920. ISSN 2045-2322 doi: https://doi.org/10.1038/s41598-018-27178-7

2017

Mellows, B., Mitchell, R., Antonioli, M., Kretz, O., Chamber, D., Zeuner, M.-T., Bernd, D., Musante, L., Durrgah, R., Debacq-Chainiaux, F., Holthofer, H., Joch, B., Ray, S., Widera, D. ORCID: https://orcid.org/0000-0003-1686-130X, David, A. L., Huber, T. B., Dengjel, J., De Coppi, P. and Patel, K. (2017) Protein and molecular characterization of a clinically compliant amniotic fluid stem cell derived extracellular vesicle fraction capable of accelerating muscle regeneration through the enhancement of angiogenesis. Stem Cells and Development, 26 (18). pp. 1316-1333. ISSN 1547-3287 doi: https://doi.org/10.1089/scd.2017.0089

Lacour, F., Vezin, E., Bentzinger, C. F., Sincennes, M.-C., Giordani, L., Ferry, A., Mitchell, R., Patel, K., Rudnicki, M. A., Chaboissier, M.-C., Chassot, A.-A. and Le Grand, F. (2017) R-spondin1 controls muscle cell fusion through dual regulation of antagonistic Wnt signaling pathways. Cell reports, 18 (10). pp. 2320-2330. ISSN 2211-1247 doi: https://doi.org/10.1016/j.celrep.2017.02.036