2024

Alharbi, H. O., Sugden, P. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2024) Mitogen-activated protein kinase signalling in rat hearts during postnatal development: MAPKs, MAP3Ks, MAP4Ks and DUSPs. Cellular Signalling, 124. 111397. ISSN 1873-3913 doi: https://doi.org/10.1016/j.cellsig.2024.111397

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Amadi, S. U., Smith, S. J. and Sugden, P. H. (2024) Inhibiting the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade in cancer and the heart: for better or worse, in sickness and health? International Journal of Drug Discovery and Pharmacology. ISSN 2653-6234 doi: https://doi.org/10.53941/ijddp.2024.100006

Cull, J. J., Cooper, S. T. E., Alharbi, H. O., Chothani, S. P., Rackham, O. J. L., Meijles, D., Dash, P. R., Kerkelä, R., Ruparelia, N., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2024) Striatin plays a major role in angiotensin II-induced cardiomyocyte and cardiac hypertrophy in mice in vivo. Clinical Science, 138 (10). pp. 573-597. ISSN 1470-8736 doi: https://doi.org/10.1042/CS20240496

2022

Alharbi, H. O., Hardyman, M. A., Cull, J. J., Markou, T., Cooper, S. T. E., Glennon, P. E., Fuller, S. J., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2022) Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice. Clinical Science, 136 (22). pp. 1661-1681. ISSN 0143-5221 doi: https://doi.org/10.1042/CS20220607

Marshall, J. J. T., Cull, J. J., Alharbi, H. O., Zaw Thin, M., Cooper, S. T. E., Barrington, C., Vanyai, H., Snoeks, T., Siow, B., Suáarez-Bonnet, A., Herbert, E., Stuckey, D. J., Cameron, A. J. M., Prin, F., Cook, A. C., Priestnall, S. L., Chotani, S., Rackham, O. J. L., Meijles, D. N., Mohun, T., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Parker, P. J. (2022) PKN2 deficiency leads both to prenatal congenital cardiomyopathy and defective angiotensin II stress responses. Biochemical Journal, 479 (13). pp. 1467-1486. ISSN 1470-8728 doi: https://doi.org/10.1042/BCJ20220281

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Meijles, D. N., Hardyman, M. A., Fuller, S. J., Chothani, S. P., Cull, J. J., Cooper, S. T. E., Alharbi, H. O., Vanezis, K., Felkin, L. E., Markou, T., Leonard, S. J., Shaw, S. W., Rackham, O. J. L., Cook, S. A., Glennon, P. E., Sheppard, M. N., Sembrat, J. C., Rojas, M., McTiernan, C. F., Barton, P. J. and Sugden, P. H. (2022) Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo. Biochemical Journal, 479 (3). pp. 401-424. ISSN 0264-6021 doi: https://doi.org/10.1042/BCJ20210615

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H. (2022) The insulin receptor family in the heart: new light on old insights. Bioscience reports, 42 (7). BSR20221212. ISSN 1573-4935 doi: https://doi.org/10.1042/BSR20221212

2021

Meijles, D. N., Cull, J. J., Cooper, S. T. E., Markou, T., Hardyman, M. A., Fuller, S. J., Alharbi, H. O., Haines, Z. H. R., Alcantara Alonso, V. ORCID: https://orcid.org/0000-0002-9782-2398, Glennon, P. E., Sheppard, M. N., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2021) The anti-cancer drug dabrafenib is not cardiotoxic and inhibits cardiac remodelling and fibrosis in a murine model of hypertension. Clinical Science, 135 (14). pp. 1631-1647. ISSN 0143-5221 doi: https://doi.org/10.1042/CS20210192

Meijles, D. N., Fuller, S. J., Cull, J. J., Alharbi, H. O., Cooper, S. T. E., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2021) The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and α1-adrenergic receptors. Biochemical Journal, 478 (11). pp. 2059-2079. ISSN 1470-8728 doi: https://doi.org/10.1042/BCJ20210144

Fuller, S. J., Edmunds, N. S., McGuffin, L. J. ORCID: https://orcid.org/0000-0003-4501-4767, Hardyman, M. A., Cull, J. J., Alharbi, H. O., Meijles, D. N., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2021) MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins. Biochemical Journal, 478 (11). pp. 2121-2143. ISSN 0264-6021 doi: https://doi.org/10.1042/BCJ20210003

2020

St George's Hospital Medical School (2020) Treatment of fibrosis With RAF inhibitors. WO 2020/161477. doi: WO 2020/161477

Meijles, D. N., Cull, J. J., Markou, T., Cooper, S. T. E., Haines, Z. H. R., Fuller, S. J., O'Gara, P., Sheppard, M. N., Harding, S. E., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2020) Redox regulation of cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) controls p38-MAPK (Mitogen-Activated Protein Kinase) and orchestrates cardiac remodelling to hypertension. Hypertension, 76 (4). pp. 1208-1218. ISSN 1524-4563 doi: https://doi.org/10.1161/HYPERTENSIONAHA.119.14556

2019

Meijles, D. N., Zoumpoulidou, G., Markou, T., Rostron, K. A., Patel, R., Lay, K., Handa, B. S., Wong, B., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2019) The cardiomyocyte "redox rheostat": Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death. Journal of molecular and cellular cardiology, 129. pp. 118-129. ISSN 1095-8584 doi: https://doi.org/10.1016/j.yjmcc.2019.02.006

2015

Fuller, S. J., Osborne, S. A., Leonard, S. J., Hardyman, M. A., Vaniotis, G., Allen, B. G., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2015) Cardiac protein kinases: the cardiomyocyte kinome and differential kinase expression in human failing hearts. Cardiovascular Research, 108 (1). pp. 87-98. ISSN 0008-6363 doi: https://doi.org/10.1093/cvr/cvv210

2014

Tindall, M. J. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2014) Modelling negative feedback networks for activating transcription factor 3 predicts a dominant role for miRNAs in immediate early gene regulation. PLoS Computational Biology, 10 (5). e1003597. ISSN 1553-734X doi: https://doi.org/10.1371/journal.pcbi.1003597

Leite-Moreira, A. F., Lourenço, A. P., Balligand, J.-L., Bauersachs, J., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, De Windt, L. J., Heymans, S., Hilfiker-Kleiner, D., Hirsch, E., Iaccarino, G., Kaminski, K. A., Knöll, R., Mayr, M., Tarone, G., Thum, T. and Tocchetti, C. G. (2014) ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models. European Journal of Heart Failure, 16 (5). pp. 509-18. ISSN 1879-0844 doi: https://doi.org/10.1002/ejhf.66

Tarone, G., Balligand, J.-L., Bauersachs, J., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, De Windt, L., Heymans, S., Hilfiker-Kleiner, D., Hirsch, E., Iaccarino, G., Knöll, R., Leite-Moreira, A. F., Lourenço, A. P., Mayr, M., Thum, T. and Tocchetti, C. G. (2014) Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology. European Journal of Heart Failure, 16 (5). pp. 494-508. ISSN 1879-0844 doi: https://doi.org/10.1002/ejhf.62

2013

Sugden, P. H., McGuffin, L. J. ORCID: https://orcid.org/0000-0003-4501-4767 and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2013) SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein–protein interactions. Biochemical Journal, 454 (1). pp. 13-30. ISSN 0264-6021 doi: https://doi.org/10.1042/BJ20130219

Barrett, O. P. T., Yndestad, A., Marshall, A. K., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2013) The early transcriptomic response to interleukin 1β and interleukin 33 in rat neonatal cardiomyocytes. Cytokine, 61 (2). pp. 340-344. ISSN 1096-0023 doi: https://doi.org/10.1016/j.cyto.2012.11.004

Amirak, E., Fuller, S. J., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2013) p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to Gq protein-coupled receptor stimuli, endothelin-1 and α1-adrenergic receptor agonists. Biochemical Journal, 450 (2). pp. 351-363. ISSN 0264-6021 doi: https://doi.org/10.1042/BJ20121371

2012

Giraldo, A., Barrett, O. P. T., Tindall, M. J., Fuller, S. J., Amirak, E., Bhattacharya, B. S., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2012) Feedback regulation by Atf3 in the endothelin-1-responsive transcriptome of cardiomyocytes: Egr1 is a principal Atf3 target. Biochemical Journal, 444 (2). pp. 343-355. ISSN 0264-6021 doi: https://doi.org/10.1042/BJ20120125

Fuller, S. J., McGuffin, L. J. ORCID: https://orcid.org/0000-0003-4501-4767, Marshall, A. K., Giraldo, A., Pikkarainen, S., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. (2012) A novel, non-canonical mechanism of regulation of MST3 (mammalian Sterile20-related kinase 3). Biochemical Journal, 442 (3). pp. 595-610. ISSN 0264-6021 doi: https://doi.org/10.1042/BJ20112000

2011

Sugden, P. H., Markou, T., Fuller, S. J., Tham, E. L., Molkentin, J. D., Paterson, H. F. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2011) Monophosphothreonyl extracellular signal-regulated kinases 1 and 2 (ERK1/2) are formed endogenously in intact cardiac myocytes and are enzymically active. Cellular Signalling, 23 (2). pp. 468-477. ISSN 0898-6568 doi: https://doi.org/10.1016/j.cellsig.2010.10.024

2010

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H. (2010) Dying by the way you live: AIF vs. caspases in apoptosis of hypertrophied cardiomyocytes. Cardiovascular research, 85 (1). pp. 3-4. ISSN 1755-3245

Marshall, A. K., Barrett, O. P. T., Cullingford, T. E., Shanmugasundram, A., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2010) ERK1/2 signaling dominates over RhoA signaling in regulating early changes in RNA expression induced by endothelin-1 in neonatal rat cardiomyocytes. PLoS ONE, 5 (4). e10027. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0010027

Yndestad, A., Marshall, A. K., Hodgkinson, J. D., Tham, E. L., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2010) Modulation of interleukin signalling and gene expression in cardiac myocytes by endothelin-1. International Journal of Biochemistry & Cell Biology, 42 (2). pp. 263-272. ISSN 1357-2725 doi: https://doi.org/10.1016/j.biocel.2009.10.021

Markou, T., Marshall, A. K., Cullingford, T. E., Tham, E. L., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2010) Regulation of the cardiomyocyte transcriptome vs translatome by endothelin-1 and insulin: translational regulation of 5' terminal oligopyrimidine tract (TOP) mRNAs by insulin. BMC Genomics, 11. 343. ISSN 1471-2164 doi: https://doi.org/10.1186/1471-2164-11-343

2009

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Cullingford, T. E., Fuller, S. J., Giraldo, A. and Sugden, P. H. (2009) Endothelin-1 regulation of immediate early gene expression in cardiac myocytes: negative feedback regulation of interleukin 6 by Atf3 and Klf2. Advances in Enzyme Regulation, 49 (1). pp. 30-42. ISSN 0065-2571 doi: https://doi.org/10.1016/j.advenzreg.2008.12.007

Pikkarainen, S., Kennedy, R. A., Marshall, A. K., Tham, E. L., Lay, K., Kriz, T. A., Handa, B. S., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H. (2009) Regulation of expression of the rat orthologue of mouse double minute 2 (MDM2) by H2O2-induced oxidative stress in neonatal rat cardiac myocytes. The Journal of Biological Chemistry, 284 (40). pp. 27195-27210. ISSN 1083-351X doi: https://doi.org/10.1074/jbc.M109.037887

2008

Cook, S. A., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H. (2008) Are transgenic mice the 'alkahest' to understanding myocardial hypertrophy and failure? Journal of Molecular and Cellular Cardiology, 46 (2). pp. 118-129. ISSN 0022-2828 doi: https://doi.org/10.1016/j.yjmcc.2008.11.005

Cullingford, T. E., Butler, M. J., Marshall, A. K., Tham, E. L., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2008) Differential regulation of Krüppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines. Biochimica Et Biophysica Acta-Molecular Cell Research, 1783 (6). pp. 1229-1236. ISSN 0167-4889 doi: https://doi.org/10.1016/j.bbamcr.2008.03.007

Sugden, P. H., Fuller, S. J., Weiss, S. C. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2008) Glycogen synthase kinase 3 (GSK3) in the heart: a point of integration in hypertrophic signalling and a therapeutic target? A critical analysis. British Journal of Pharmacology, 153 (S1). S137-S153. ISSN 1476-5381 doi: https://doi.org/10.1038/sj.bjp.0707659

Prasad, S. K., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Cullingford, T. E., Chen, A. W. Y., Kemp, T. J., Cannell, T. M., Cowie, M. R. and Petrou, M. (2008) Gene expression profiling of human hibernating myocardium: Increased expression of B-type natriuretic peptide and proenkephalin in hypocontractile vs normally-contracting regions of the heart. European Journal of Heart Failure, 10 (12). pp. 1177-1180. ISSN 1388-9842 doi: https://doi.org/10.1016/j.ejheart.2008.08.008

Markou, T., Cullingford, T. E., Giraldo Ramirez, A., Weiss, S. C., Alsafi, A., Fuller, S. J., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H. (2008) Glycogen synthase kinases 3α and 3β in cardiac myocytes: regulation and consequences of their inhibition. Cellular Signalling, 20 (1). pp. 206-218. ISSN 0898-6568 doi: https://doi.org/10.1016/j.cellsig.2007.10.004

Fuller, S. J., Pikkarainen, S., Tham, E. L., Cullingford, T. E., Molkentin, J. D., Cornils, H., Hergovitch, A., Hemmings, B. A., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H. (2008) Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors. Cellular Signalling, 20 (8). pp. 1564-1577. ISSN 0898-6568 doi: https://doi.org/10.1016/j.cellsig.2008.04.013

Cullingford, T. E., Markou, T., Fuller, S. J., Giraldo, A., Pikkarainern, S., Zoumpoulidou, G., Alsafi, A., Ekere, C., Kemp, T. J., Dennis, J. L., Game, L., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2008) Temporal regulation of expression of immediate early and second phase transcripts by endothelin-1 in cardiomyocytes. Genome Biology, 9 (2). R32. ISSN 1474-760X doi: https://doi.org/10.1186/gb-2008-9-2-r32

2007

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Cullingford, T. E., Fuller, S. J., Giraldo, A., Markou, T., Pikkarainen, S. and Sugden, P. (2007) Signaling pathways mediating cardiac myocyte gene expression in physiological and stress responses. Journal of cellular physiology, 212 (2). pp. 311-322. ISSN 0021-9541 doi: https://doi.org/10.1002/jcp.21094

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Kemp, T. J., Zoumpoulidou, G. and Sugden, P. (2007) Cardiac myocyte gene expression profiling during H2O2-induced apoptosis. Physiological genomics, 29 (2). pp. 118-127. ISSN 1531-2267 doi: https://doi.org/10.1152/physiolgenomics.00168.2006

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Giraldo, A. and Sugden, P. (2007) Chemotherapeutic agents and gene expression in cardiac myocytes. Advances in Enzyme Regulation, 47 (1). pp. 140-153. ISSN 0065-2571 doi: https://doi.org/10.1016/j.advenzreg.2006.12.004

2006

Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2006) Oxidative stress and growth-regulating intracellular signaling pathways in cardiac myocytes. Antioxidants & Redox Signaling, 8 (11-12). pp. 2111-2124. ISSN 1523-0864 doi: https://doi.org/10.1089/ars.2006.8.2111

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. (2006) Ras: the stress and the strain. Journal of Molecular and Cellular Cardiology, 41 (4). pp. 595-600. ISSN 0022-2828 doi: https://doi.org/10.1016/j.yjmcc.2006.06.075

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. (2006) Inflame my heart (by p38-MAPK). Circulation Research, 99 (5). pp. 455-458. ISSN 0009-7330 doi: https://doi.org/10.1161/01.RES.0000241053.89089.c3

Kennedy, R. A., Kemp, T. J., Sugden, P. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2006) Using U0126 to dissect the role of the extracellular signal-regulated kinase 1/2 (ERK1/2) cascade in the regulation of gene expression by endothelin-1 in cardiac myocytes. Journal of Molecular and Cellular Cardiology, 41 (2). pp. 236-247. ISSN 0022-2828 doi: https://doi.org/10.1016/j.yjmcc.2006.04.011

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Aggeli, I.-K. S., Stathopoulou, K. and Sugden, P. H. (2006) Peptide growth factors signal differentially through protein kinase C to extracellular signal-regulated kinases in neonatal cardiomyocytes. Cellular Signalling, 18 (2). pp. 225-235. ISSN 0898-6568 doi: https://doi.org/10.1016/j.cellsig.2005.04.005

Cullingford, T. E., Wait, R., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H. (2006) Effects of oxidative stress on the cardiac myocyte proteome: modifications to peroxiredoxins and small heat shock proteins. Journal of Molecular and Cellular Cardiology, 40 (1). pp. 157-172. ISSN 0022-2828 doi: https://doi.org/10.1016/j.yjmcc.2005.10.004

2005

Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2005) Endothelin signalling in the cardiac myocyte and its pathophysiological relevance. Current vascular pharmacology, 3 (4). pp. 343-351. ISSN 1570-1611 doi: https://doi.org/10.2174/157016105774329390

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Cullingford, T. E., Kemp, T. J., Kennedy, R. A. and Sugden, P. H. (2005) Regulation of gene and protein expression in cardiac myocyte hypertrophy and apoptosis. Advances in Enzyme Regulation, 45 (1). pp. 94-111. ISSN 0065-2571 doi: https://doi.org/10.1016/j.advenzreg.2005.02.007

2004

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H. (2004) Signaling through the extracellular signal-regulated kinase 1/2 cascade in cardiac myocytes. Biochemistry and cell biology = Biochimie et biologie cellulaire, 82 (6). pp. 603-9. ISSN 0829-8211

Kemp, T. J., Aggeli, I.-K., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2004) Phenylephrine and endothelin-1 upregulate connective tissue growth factor in neonatal rat cardiac myocytes. Journal of molecular and cellular cardiology, 37 (2). pp. 603-6. ISSN 0022-2828

Harrison, J. G., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2004) Endothelin-1 promotes phosphorylation of CREB transcription factor in primary cultures of neonatal rat cardiac myocytes: implications for the regulation of c-jun expression. Biochimica et biophysica acta, 1644 (1). pp. 17-25. ISSN 0006-3002

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Kemp, T. J., Harrison, J. G., Pham, F. H. and Sugden, P. H. (2004) Integration of protein kinase signaling pathways in cardiac myocytes: signaling to and from the extracellular signal-regulated kinases. Advances in enzyme regulation, 44. pp. 233-48. ISSN 0065-2571

2003

Kemp, T. J., Causton, H. C. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2003) Changes in gene expression induced by H(2)O(2) in cardiac myocytes. Biochemical and biophysical research communications, 307 (2). pp. 416-21. ISSN 0006-291X

Valks, D. M., Kemp, T. J. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2003) Regulation of Bcl-xL expression by H2O2 in cardiac myocytes. The Journal of biological chemistry, 278 (28). pp. 25542-7. ISSN 0021-9258

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2003) The radical balance between life and death. Journal of molecular and cellular cardiology, 35 (6). pp. 599-602. ISSN 0022-2828

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Cole, S. M., Cullingford, T. E., Harrison, J. G., Jormakka, M. and Valks, D. M. (2003) Regulation of cardiac myocyte cell death. Pharmacology & therapeutics, 97 (3). pp. 223-61. ISSN 0163-7258

Vlahos, C. J., McDowell, S. A. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2003) Kinases as therapeutic targets for heart failure. Nature reviews. Drug discovery, 2 (2). pp. 99-113. ISSN 1474-1776

2002

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Kemp, T. J., Harrison, J. G., Mullen, A. J., Barton, P. J. R. and Sugden, P. H. (2002) Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein. The Biochemical journal, 368 (Pt 1). pp. 101-10. ISSN 0264-6021

Valks, D. M., Cook, S. A., Pham, F. H., Morrison, P. R., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H. (2002) Phenylephrine promotes phosphorylation of Bad in cardiac myocytes through the extracellular signal-regulated kinases 1/2 and protein kinase A. Journal of molecular and cellular cardiology, 34 (7). pp. 749-63. ISSN 0022-2828

2001

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H. (2001) Untangling the Web: specific signaling from PKC isoforms to MAPK cascades. Circulation research, 89 (10). pp. 847-9. ISSN 1524-4571

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2001) Death by protein kinase C inhibitor: a stressful event. Journal of molecular and cellular cardiology, 33 (10). pp. 1773-6. ISSN 0022-2828

Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2001) Akt like a woman: gender differences in susceptibility to cardiovascular disease. Circulation research, 88 (10). pp. 975-7. ISSN 1524-4571

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Pham, F. H., Fuller, S. J., Sahai, E., Aktories, K., Marais, R., Marshall, C. and Sugden, P. H. (2001) Regulation of mitogen-activated protein kinases in cardiac myocytes through the small G protein Rac1. Molecular and cellular biology, 21 (4). pp. 1173-84. ISSN 0270-7306

Pham, F. H., Cole, S. M. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2001) Regulation of cardiac myocyte protein synthesis through phosphatidylinositol 3' kinase and protein kinase B. Advances in enzyme regulation, 41. pp. 73-86. ISSN 0065-2571

2000

Pham, F. H., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2000) Regulation of protein kinase B and 4E-BP1 by oxidative stress in cardiac myocytes. Circulation research, 86 (12). pp. 1252-8. ISSN 1524-4571

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H. (2000) Small guanine nucleotide-binding proteins and myocardial hypertrophy. Circulation research, 86 (10). pp. 1019-23. ISSN 1524-4571

Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2000) Activation of the small GTP-binding protein Ras in the heart by hypertrophic agonists. Trends in cardiovascular medicine, 10 (1). pp. 1-8. ISSN 1050-1738

1999

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Harrison, J. G., Long, C. S. and Sugden, P. H. (1999) Pro-inflammatory cytokines stimulate mitogen-activated protein kinase subfamilies, increase phosphorylation of c-Jun and ATF2 and upregulate c-Jun protein in neonatal rat ventricular myocytes. Journal of molecular and cellular cardiology, 31 (12). pp. 2087-99. ISSN 0022-2828

Cook, S. A., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (1999) Regulation of bcl-2 family proteins during development and in response to oxidative stress in cardiac myocytes: association with changes in mitochondrial membrane potential. Circulation research, 85 (10). pp. 940-9. ISSN 1524-4571

Ping, P., Zhang, J., Huang, S., Cao, X., Tang, X. L., Li, R. C., Zheng, Y. T., Qiu, Y., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Sugden, P., Han, J. and Bolli, R. (1999) PKC-dependent activation of p46/p54 JNKs during ischemic preconditioning in conscious rabbits. The American journal of physiology, 277 (5 Pt 2). H1771-85. ISSN 0002-9513

Cook, S. A., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (1999) Activation of c-Jun N-terminal kinases and p38-mitogen-activated protein kinases in human heart failure secondary to ischaemic heart disease. Journal of molecular and cellular cardiology, 31 (8). pp. 1429-34. ISSN 0022-2828

Chiloeches, A., Paterson, H. F., Marais, R., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Marshall, C. J. and Sugden, P. H. (1999) Regulation of Ras.GTP loading and Ras-Raf association in neonatal rat ventricular myocytes by G protein-coupled receptor agonists and phorbol ester. Activation of the extracellular signal-regulated kinase cascade by phorbol ester is mediated by Ras. The Journal of biological chemistry, 274 (28). pp. 19762-70. ISSN 0021-9258

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H. (1999) Activation of protein kinase cascades in the heart by hypertrophic G protein-coupled receptor agonists. The American journal of cardiology, 83 (12A). 64H-69H. ISSN 0002-9149

1998

Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (1998) Cellular mechanisms of cardiac hypertrophy. Journal of molecular medicine (Berlin, Germany), 76 (11). pp. 725-46. ISSN 0946-2716

Haq, S. E., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H. (1998) Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by adenosine in the perfused rat heart. FEBS letters, 434 (3). pp. 305-8. ISSN 0014-5793

Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (1998) "Stress-responsive" mitogen-activated protein kinases (c-Jun N-terminal kinases and p38 mitogen-activated protein kinases) in the myocardium. Circulation research, 83 (4). pp. 345-52. ISSN 0009-7330

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Michael, A. and Sugden, P. H. (1998) Stimulation of multiple mitogen-activated protein kinase sub-families by oxidative stress and phosphorylation of the small heat shock protein, HSP25/27, in neonatal ventricular myocytes. The Biochemical journal, 333 ( Pt 3. pp. 581-9. ISSN 0264-6021

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Michael, A. and Sugden, P. H. (1998) Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein-coupled receptor agonists, endothelin-1 and phenylephrine: a role in cardiac myocyte hypertrophy? The Journal of cell biology, 142 (2). pp. 523-35. ISSN 0021-9525

Lazou, A., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (1998) Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. The Biochemical journal, 332 ( Pt 2. pp. 459-65. ISSN 0264-6021

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H. (1998) The p38-MAPK inhibitor, SB203580, inhibits cardiac stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs). FEBS letters, 426 (1). pp. 93-6. ISSN 0014-5793

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Fuller, S. J., Michael, A. and Sugden, P. H. (1998) Stimulation of "stress-regulated" mitogen-activated protein kinases (stress-activated protein kinases/c-Jun N-terminal kinases and p38-mitogen-activated protein kinases) in perfused rat hearts by oxidative and other stresses. The Journal of biological chemistry, 273 (13). pp. 7228-34. ISSN 0021-9258

Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (1998) Regulation of mitogen-activated protein kinase cascades in the heart. Advances in enzyme regulation, 38. pp. 87-98. ISSN 0065-2571

1997

Sugden, P. H., Fuller, S. J., Michael, A. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (1997) Activation of mitogen-activated protein kinase subfamilies by oxidative stress in the perfused rat heart. Biochemical Society transactions, 25 (4). S565. ISSN 0300-5127

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H. (1997) Mitogen-activated protein kinases are activated by oxidative stress and cytokines in neonatal rat ventricular myocytes. Biochemical Society transactions, 25 (4). S566. ISSN 0300-5127

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H. (1997) Cell stress-induced phosphorylation of ATF2 and c-Jun transcription factors in rat ventricular myocytes. The Biochemical journal, 325 ( Pt 3. pp. 801-10. ISSN 0264-6021

Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (1997) Regulation of the ERK subgroup of MAP kinase cascades through G protein-coupled receptors. Cellular signalling, 9 (5). pp. 337-51. ISSN 0898-6568

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H. (1997) Regulation of phospholipases C and D in rat ventricular myocytes: stimulation by endothelin-1, bradykinin and phenylephrine. Journal of molecular and cellular cardiology, 29 (6). pp. 1593-604. ISSN 0022-2828

Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (1997) Cell stresses regulate the phosphorylation state of c-Jun and ATF2 in ventricular myocytes. Biochemical Society transactions, 25 (2). 221S. ISSN 0300-5127

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H. (1997) Phosphorylation c-Jun and ATF2 in ventricular myocytes by endothelin and phenylephrine. Biochemical Society transactions, 25 (2). 222S. ISSN 0300-5127

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H. (1997) Activation of p21-activated protein kinase alpha (alpha PAK) by hyperosmotic shock in neonatal ventricular myocytes. FEBS letters, 403 (1). pp. 23-5. ISSN 0014-5793

1996

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Gillespie-Brown, J., Fuller, S. J. and Sugden, P. H. (1996) Stimulation of phosphatidylinositol hydrolysis, protein kinase C translocation, and mitogen-activated protein kinase activity by bradykinin in rat ventricular myocytes: dissociation from the hypertrophic response. The Biochemical journal, 317 ( Pt 1. pp. 109-18. ISSN 0264-6021

Bogoyevitch, M. A., Andersson, M. B., Gillespie-Brown, J., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Glennon, P. E., Fuller, S. J. and Sugden, P. H. (1996) Adrenergic receptor stimulation of the mitogen-activated protein kinase cascade and cardiac hypertrophy. The Biochemical journal, 314 ( Pt 1. pp. 115-21. ISSN 0264-6021

1995

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Bogoyevitch, M. A., Fuller, S. J., Lazou, A., Parker, P. J. and Sugden, P. H. (1995) Expression of protein kinase C isoforms during cardiac ventricular development. The American journal of physiology, 269 (3 Pt 2). H1087-97. ISSN 0002-9513

Bogoyevitch, M. A., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Sugden, P. H. (1995) Activation of the mitogen-activated protein kinase cascade by pertussis toxin-sensitive and -insensitive pathways in cultured ventricular cardiomyocytes. The Biochemical journal, 309 ( Pt 2. pp. 437-43. ISSN 0264-6021

1994

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Bogoyevitch, M. A., Anderson, M. B. and Sugden, P. H. (1994) Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts. The Journal of biological chemistry, 269 (52). pp. 32848-57. ISSN 0021-9258

Lazou, A., Bogoyevitch, M. A., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Fuller, S. J., Marshall C, J. and Sugden, P. H. (1994) Regulation of mitogen-activated protein kinase cascade in adult rat heart preparations in vitro. Circulation research, 75 (5). pp. 932-41. ISSN 0009-7330

Bogoyevitch, M. A., Glennon, P. E., Andersson, M. B., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Lazou, A., Marshall, C. J., Parker, P. J. and Sugden, P. H. (1994) Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy. The Journal of biological chemistry, 269 (2). pp. 1110-9. ISSN 0021-9258

1993

Muntoni, F., Mateddu, A., Marchei, F., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 and Serra, G. (1993) Muscular weakness in the mdx mouse. Journal of the neurological sciences, 120 (1). pp. 71-7. ISSN 0022-510X

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Bogoyevitch, M. A., Parker, P. J. and Sugden, P. H. (1993) Down-regulation of protein kinase C isotypes during postnatal development of rat heart. Biochemical Society transactions, 21 (4). 385S. ISSN 0300-5127

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Morris, G. E., Dubowitz, V., Davies, K. E. and Sewry, C. A. (1993) Dystrophin-related protein, utrophin, in normal and dystrophic human fetal skeletal muscle. The Histochemical journal, 25 (8). pp. 554-61. ISSN 0018-2214

Sewry, C. A., Sansome, A., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Sherratt, T. G., Hasson, N., Rodillo, E., Heckmatt, J. Z., Strong, P. N. and Dubowitz, V. (1993) Manifesting carriers of Xp21 muscular dystrophy; lack of correlation between dystrophin expression and clinical weakness. Neuromuscular disorders : NMD, 3 (2). pp. 141-8. ISSN 0960-8966

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Muntoni, F. and Strong, P. N. (1993) A dystrophin-immunoreactive protein in mammalian brain. Journal of neurochemistry, 60 (2). pp. 435-41. ISSN 0022-3042

Muntoni, F., Mateddu, A., Cianchetti, C., Marrosu, M. G., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Cau, M., Congiu, R., Cao, A. and Melis, M. A. (1993) Dystrophin analysis using a panel of anti-dystrophin antibodies in Duchenne and Becker muscular dystrophy. Journal of Neurology, Neurosurgery, and Psychiatry, 56 (1). pp. 26-31. ISSN 0022-3050

1992

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Sewry, C. A., Dubowitz, V. and Strong, P. N. (1992) Characterisation of dystrophin in fetuses at risk for Duchenne muscular dystrophy. Journal of Neurological Sciences, 111 (1). pp. 82-91. ISSN 0022-510X

Torelli, S., Sogos, V., Ennas, M. G., Muntoni, F., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Strong, P. N. and Gremo, F. (1992) Dystrophin immunoreactivity in normal and Duchenne human fetal neurons in culture. Journal of neuroscience research, 32 (1). pp. 116-25. ISSN 0360-4012

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Strong, P. N. and Sewry, C. A. (1992) Characterisation of dystrophin during development of human skeletal muscle. Development (Cambridge, England), 114 (2). pp. 395-402. ISSN 0950-1991

1991

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Rodillo, E., Heckmatt, J. Z., Dubowitz, V., Strong, P. N. and Sewry, C. A. (1991) Characterisation of dystrophin in carriers of Duchenne muscular dystrophy. Journal of Neurological Sciences, 102 (2). pp. 197-205. ISSN 0022-510X

Sewry, C. A., Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Heckmatt, J. Z., Vyse, T., Dubowitz, V. and Strong, P. N. (1991) Dystrophin abnormalities in polymyositis and dermatomyositis. Neuromuscular disorders : NMD, 1 (5). pp. 333-9. ISSN 0960-8966

1990

Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708, Muntoni, F. and Strong, P. (1990) Dystrophin and dystrophin-like proteins in muscle and brain of normal and mdx mice. Biochemical Society Transactions, 18 (3). pp. 388-9. ISSN 0300-5127