Article

Bryant, L. A., Shankland, K. ORCID: https://orcid.org/0000-0001-6566-0155, Straker, H. E., Johnston, C. D., Lees, N. R. and Cobb, A. J.A. (2021) Enantioselective organocatalytic synthesis of bicyclic resorcinols via an intramolecular Friedel-Crafts-type 1,4-addition: access to cannabidiol analogues. Advanced Synthesis and Catalysis, 363 (16). pp. 4067-4074. ISSN 1615-4169 doi: https://doi.org/10.1002/adsc.202100647

Townsend, D., Shankland, K. ORCID: https://orcid.org/0000-0001-6566-0155, Weymouth-Wilson, A., Komsta, Z., Evans, T. and Cobb, A. (2020) Highly enantioselective, organocatalytic and scalable synthesis of a rare cis-cis-tricyclic diterpenoid. Chemistry- A European Journal, 26 (16). pp. 3504-3508. ISSN 1521-3765 doi: https://doi.org/10.1002/chem.202000164

Fanelli, R., Berta, D., Foldes, T., Rosta, E., Atkinson, R. A., Hofmann, H.-J., Shankland, K. ORCID: https://orcid.org/0000-0001-6566-0155 and Cobb, A. (2020) Organocatalytic access to a cis-Cyclopentyl-gamma-amino acid: an intriguing model of selectivity and formation of a stable 10/12-helix from the corresponding gamma/alpha-peptide. Journal of the American Chemical Society, 142 (3). pp. 1382-1393. ISSN 1520-5126 doi: https://doi.org/10.1021/jacs.9b10861

Arezki, N. R., Williams, A. C. ORCID: https://orcid.org/0000-0003-3654-7916, Cobb, A. J. A. and Brown, M. B. (2017) Design, synthesis and characterisation of linear unnatural amino acids for skin moisturisation. International Journal of Cosmetic Science, 39 (1). pp. 72-82. ISSN 1468-2494 doi: https://doi.org/10.1111/ics.12351

Arezki, N. R., Williams, A. C. ORCID: https://orcid.org/0000-0003-3654-7916, Cobb, A. J. A. and Brown, M. B. (2017) Design, synthesis and characterization of linear unnatural amino acids for skin moisturization. International Journal of Cosmetic Science, 39 (1). pp. 72-82. ISSN 1468-2494 doi: https://doi.org/10.1111/ics.12351

Bryant, L. A., Fanelli, R. and Cobb, A. J. A. (2016) Cupreines and cupreidines: an established class of bifunctional cinchona organocatalysts. Beilstein Journal of Organic Chemistry, 12. pp. 429-443. ISSN 1860-5397 doi: https://doi.org/10.3762/bjoc.12.46

Al-Ani, W., Shankland, K. ORCID: https://orcid.org/0000-0001-6566-0155 and Cobb, A. J. A. (2016) Asymmetric organocatalytic synthesis of cyclopentane γ-nitroketones. Synlett, 27 (1). pp. 17-20. ISSN 0936-5214 doi: https://doi.org/10.1055/s-0035-1560504

Aitken, L. S., Hammond, L. E., Sundaram, R., Shankland, K. ORCID: https://orcid.org/0000-0001-6566-0155, Brown, G. D. and Cobb, A. J. A. (2015) Asymmetric cyclopropanation of conjugated cyanosulfones using a novel cupreine organocatalyst: rapid access to d3-amino acids. Chemical Communications, 51 (70). pp. 13558-13561. ISSN 1359-7345 doi: https://doi.org/10.1039/c5cc05158d

Gadd, A. J. R., Greco, F., Cobb, A. J. A. and Edwards, A. D. ORCID: https://orcid.org/0000-0003-2369-989X (2015) Targeted activation of toll-like receptors: conjugation of a toll-like receptor 7 agonist to a monoclonal antibody maintains antigen binding and specificity. Bioconjugate Chemistry, 26 (8). pp. 1743-1752. ISSN 1043-1802 doi: https://doi.org/10.1021/acs.bioconjchem.5b00302

Dell'Isola, A., McLachlan, M. M. W., Neuman, B. W., Al-Mullah, H. M. N., Binks, A. W. D., Elvidge, W., Shankland, K. ORCID: https://orcid.org/0000-0001-6566-0155 and Cobb, A. J. A. (2014) Synthesis and antiviral properties of spirocyclic [1,2,3]-triazolooxazine nucleosides. Chemistry- A European Journal, 20 (37). pp. 11685-11689. ISSN 0947-6539 doi: https://doi.org/10.1002/chem.201403560

Cobb, A., Arezki, N., Dell'Isola, A. and Aitken, L. (2013) Asymmetric organocatalysis and the nitro group functionality. Synthesis-Stuttgart, 45 (19). pp. 2627-2648. ISSN 0039-7881 doi: https://doi.org/10.1055/s-0033-1338522

Rajkumar, S., Shankland, K. ORCID: https://orcid.org/0000-0001-6566-0155, Goodman, J. M. and Cobb, A. J.A. (2013) Organocatalytic domino reaction of cyanosulfones: access to complex cyclohexane systems with quaternary carbon centers. Organic Letters, 15 (6). pp. 1386-1389. ISSN 1523-7060 doi: https://doi.org/10.1021/ol400356k

Rajkumar, S., Shankland, K. ORCID: https://orcid.org/0000-0001-6566-0155, Brown, G. D. and Cobb, A. (2012) Organocatalytic enantioselective construction of nitrocyclohexanes containing multiple chiral centres via a cascade reaction. Chemical Science, 3. pp. 584-588. ISSN 1478-6524 doi: https://doi.org/10.1039/C1SC00592H

Rangam, G., Schmitz, K.-M., Cobb, A. and Petersen-Mahrt, S. (2012) AID enzymatic activity is inversely proportional to the size of cytosine C5 orbital cloud. PloS ONE, 7 (8). e43279. ISSN 1932-6203 doi: https://doi.org/10.1371/journal.pone.0043279

Shaikh, A. K., Cobb, A. J. A. and Varvounis, G. (2012) Mild and rapid method for the generation of ortho-(naphtho)-quinone methide intermediates. Organic Letters, 14 (2). pp. 584-587. ISSN 1523-7060 doi: https://doi.org/10.1021/ol203196n

Fern, S. E., Heath, P. and Cobb, A. J. A. (2011) Aldol reaction of butane-2,3-diacetal protected methyl glycerate. Tetrahedron: Asymmetry, 22 (2). pp. 149-152. ISSN 0957-4166 doi: https://doi.org/10.1016/j.tetasy.2011.01.004

Nodes, W. J., Shankland, K. ORCID: https://orcid.org/0000-0001-6566-0155, Rajkumar, S. and Cobb, A. J. A. (2010) Asymmetric phase-transfer-catalyzed synthesis of five-membered cyclic gamma-Amino acid precursors. Synlett, 2010 (20). pp. 3011-3014. ISSN 1437-2096 doi: https://doi.org/10.1055/s-0030-1259050

Kolstoe, S. E., Mangione, P. P., Bellotti, V., Taylor, G. W., Tennent, G. A., Deroo, S., Morrison, A. J., Cobb, A. J. A., Coyne, A., McCammon, M. G., Warner, T. D., Mitchell, J., Gill, R., Smith, M. D., Ley, S. V., Robinson, S. P. and Pepys, M. B. (2010) Trapping of palindromic ligands within native transthyretin prevents amyloid formation. Proceedings of the National Academy of Sciences of the United States of America, 107 (47). pp. 20483-20488. ISSN 0027-8424 doi: https://doi.org/10.1073/pnas.1008255107

Nodes, W., Nutt, D. R., Chippindale, A. M. ORCID: https://orcid.org/0000-0002-5918-8701 and Cobb, A. J. A. (2009) Enantioselective Intramolecular Michael Addition of Nitronates onto Conjugated Esters: Access to Cyclic γ-Amino Acids with up to Three Stereocenters. Journal of the American Chemical Society, 131 (44). pp. 16016-16017. ISSN 0002-7863 doi: https://doi.org/10.1021/ja9070915

Cobb, A.J.A. (2007) Recent highlights in modified oligonucleotide chemistry. Organic & Biomolecular Chemistry, 5 (20). pp. 3260-3275. ISSN 1477-0520 doi: https://doi.org/10.1039/b709797m

Pepys, M.B., Hirschfield, G.M., Tennent, G.A., Gallimore, J.R., Kahan, M.C., Bellotti, V., Hawkins, P.N., Myers, R.M., Smith, M.D., Polara, A., Cobb, A.J.A., Ley, S.V., Aquilina, J.A., Robinson, C.V., Sharif, I., Gray, G.A., Sabin, C.A., Jenvey, M.C., Kolstoe, S.E., Thompson, D. and Wood, S.P. (2006) Targeting C-reactive protein for the treatment of cardiovascular disease. Nature, 440 (7088). pp. 1217-1221. ISSN 0028-0836 doi: https://doi.org/10.1038/nature04672

Cobb, A.J.A. and Marson, C.M. (2005) Asymmetric synthesis using catalysts containing multiple stereogenic centres and a trans-1,2-diaminocyclohexane core; reversal of predominant enantioselectivity upon N-alkylation. Tetrahedron, 61 (5). pp. 1269-1279. ISSN 0040-4020 doi: https://doi.org/10.1016/j.tet.2004.11.030

Cobb, A.J.A., Shaw, D.M., Longbottom, D.A., Gold, J.B. and Ley, S.V. (2005) Organocatalysis with proline derivatives: improved catalysts for the asymmetric Mannich, nitro-Michael and aldol reactions. Organic & Biomolecular Chemistry, 3 (1). pp. 84-96. ISSN 1477-0520 doi: https://doi.org/10.1039/b414742a

Mitchell, C.E.T., Cobb, A.J.A. and Ley, S.V. (2005) A homo-proline tetrazole as an improved organocatalyst for the asymmetric Michael addition of carbonyl compounds to nitro-olefins. Synlett (4). pp. 611-614. ISSN 0936-5214 doi: https://doi.org/10.1055/s-2005-862392

Book or Report Section

Cobb, A. (2011) General aspects of organocatalytic cyclizations. In: Mahrwald, R. (ed.) Enantioselective Organocatalyzed Reactions II: Asymmetric C-C Bond Formation Processes. Springer, pp. 1-40. ISBN 9789048138661

Cobb, A.J.A. and Ley, S.V. (2009) 5-pyrrolidin-2-yl tetrazole. In: Paquette, L.A. (ed.) Encyclopedia of reagents for organic synthesis. Wiley, Chichester. ISBN 9780470017548