Number of items: 34.
Article
Gaspar, R. S., Unsworth, A. J., Al-Dibouni, A., Bye, A. P., Sage, T., Stewart, M., Cox, R. D., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352, Sellayah, D. and Hughes, C. ORCID: https://orcid.org/0000-0002-9790-5820
(2021)
Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring.
Scientific Reports, 11.
1473.
ISSN 2045-2322
doi: https://doi.org/10.1038/s41598-020-80373-3
Soriano Jerez, E. M., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 and Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820
(2021)
Targeting platelet inhibition receptors for novel therapies: PECAM-1 and G6b-B.
Platelets, 32 (6).
pp. 761-769.
ISSN 0953-7104
doi: https://doi.org/10.1080/09537104.2021.1882668
Nicolson, P. L., Nock, S. H., Hinds, J., Garcia-Quintanilla, L., Smith, C. W., Campos, J., Brill, A., Pike, J. A., Khan, A. O., Poulter, N. S., Kavanagh, D. M., Watson, S., Watson, C. N., Clifford, H., Huissoon, A. P., Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154, Eble, J. A., Pratt, G., Watson, S. P. and Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820
(2020)
Low dose Btk inhibitors selectively block platelet activation by CLEC-2.
Haematologica, 105 (1).
ISSN 1592-8721
doi: https://doi.org/10.3324/haematol.2019.218545
Nicolson, P. L. R., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Watson, S., Nock, S. H., Hardy, A. T., Watson, C. N., Montague, S. J., Clifford, H., Huissoon, A. P., Malcor, J.-D., Thomas, M. R., Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154, Tomlinson, M. G., Pratt, G. and Watson, S. P.
(2018)
Inhibition of Btk by Btk-specific concentrations of ibrutinib and acalabrutinib delays but does not block platelet aggregation to GPVI.
Haematologica, 103 (12).
pp. 2097-2108.
ISSN 1592-8721
doi: https://doi.org/10.3324/haematol.2018.193391
Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820
(2018)
How to perform aggregometry and lumi-aggregometry in mouse platelets.
Platelets, 29 (7).
pp. 638-643.
ISSN 0953-7104
doi: https://doi.org/10.1080/09537104.2018.1478074
Mangin, P. H., Onselaer, M.-B., Receveur, N., Le Lay, N., Hardy, A. T., Wilson, C., Sanchez, X., Loyau, S., Dupuis, A., Babar, A. K., Miller, J. L. C., Philippou, H., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Herr, A. B., Ariens, R. A., Mezzano, D., Jandrot-Perrus, M., Gachet, C. and Watson, S. P.
(2018)
Immobilized fibrinogen activates human platelets through GPVI.
Hematologica, 103 (5).
pp. 898-907.
ISSN 1592-8721
doi: https://doi.org/10.3324/haematol.2017.182972
Lombard, S. E., Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154, Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Di, Y., Mckinnon, T., O'Callaghan, C. A. and Watson, S. P.
(2018)
Mouse podoplanin supports adhesion and aggregation of platelets under arterial shear: a novel mechanism of haemostasis.
Platelets, 29 (7).
pp. 716-722.
ISSN 0953-7104
doi: https://doi.org/10.1080/09537104.2017.1356919
Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Unsworth, A. J., Desborough, M. J., Hildyard, C. A. T., Appleby, N., Bruce, D., Kriek, N., Nock, S. H., Sage, T., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820 and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352
(2017)
Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib.
Blood Advances, 1 (26).
pp. 2610-2623.
ISSN 2473-9529
doi: https://doi.org/10.1182/bloodadvances.2017011999
Alshehri, O. M., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Montague, S., Watson, S. K., Frampton, J., Bender, M. and Watson, S. P.
(2015)
Fibrin activates GPVI in human and mouse platelets.
Blood, 126 (13).
pp. 1601-1608.
ISSN 0006-4971
doi: https://doi.org/10.1182/blood-2015-04-641654
Alshehri, O. M., Montague, S., Watson, S., Carter, P., Sarker, N., Manne, B. K., Miller, J. L. C., Herr, A. B., Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154, O'Callaghan, C. A., Kunapuli, S., Arman, M., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820 and Watson, S. P.
(2015)
Activation of glycoprotein VI (GPVI) and C-type lectin-like receptor-2 (CLEC-2) underlies platelet activation by diesel exhaust particles and other charged/hydrophobic ligands.
Biochemical Journal, 468 (3).
pp. 459-473.
ISSN 0264-6021
doi: https://doi.org/10.1042/BJ20150192
Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Finney, B. A., Koentgen, F., Lowe, K. L. and Watson, S. P.
(2015)
The N-terminal SH2 domain of Syk is required for (hem)ITAM, but not integrin, signaling in mouse platelets.
Blood, 125 (1).
pp. 144-154.
ISSN 0006-4971
doi: https://doi.org/10.1182/blood-2014-05-579375
Cherpokova, D., Bender, M., Morowski, M., Kraft, P., Schuhmann, M. K., Akbar, S. M., Sultan, C. S., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Kleinschnitz, C., Stoll, G., Dragone, L. L., Watson, S. P., Tomlinson, M. G. and Nieswandt, B.
(2015)
SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice.
Blood, 125 (1).
pp. 185-194.
ISSN 0006-4971
doi: https://doi.org/10.1182/blood-2014-06-580597
Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154, Poulter, N. S., Gitz, E., Navarro-Nuñez, L., Wang, Y.-J., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Thomas, S. G., Nieswandt, B., Douglas, M. R., Owen, D. M., Jackson, D. G., Dustin, M. L. and Watson, S. P.
(2014)
Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells.
The Journal of Biological Chemistry, 289 (52).
pp. 35695-35710.
ISSN 1083-351X
doi: https://doi.org/10.1074/jbc.M114.584284
Dütting, S., Vögtle, T., Morowski, M., Schiessl, S., Schäfer, C. M., Watson, S. K., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Ackermann, J. A., Radtke, D., Hermanns, H. M., Watson, S. P., Nitschke, L. and Nieswandt, B.
(2014)
Growth factor receptor-bound protein 2 contributes to (hem)immunoreceptor tyrosine-based activation motif-mediated signaling in platelets.
Circulation Research, 114 (3).
pp. 444-453.
ISSN 0009-7330
doi: https://doi.org/10.1161/CIRCRESAHA.114.302670
Manne, B. K., Getz, T. M., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Alshehri, O., Dangelmaier, C., Naik, U. P., Watson, S. P. and Kunapuli, S. P.
(2013)
Fucoidan is a novel platelet agonist for the C-type lectin-like receptor 2 (CLEC-2).
The Journal of Biological Chemistry, 288 (11).
pp. 7717-7726.
ISSN 1083-351X
doi: https://doi.org/10.1074/jbc.M112.424473
Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Sinha, U., Pandey, A., Eble, J. A., O'Callaghan, C. A. and Watson, S. P.
(2013)
Critical role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2).
The Journal of Biological Chemistry, 288 (7).
pp. 5127-5135.
ISSN 1083-351X
doi: https://doi.org/10.1074/jbc.M112.411462
Finney, B. A., Schweighoffer, E., Navarro-Núñez, L., Bénézech, C., Barone, F., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Langan, S. A., Lowe, K. L., Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154, Mourao-Sa, D., Sheardown, S., Nash, G. B., Smithers, N., Reis e Sousa, C., Tybulewicz, V. L. J. and Watson, S. P.
(2012)
CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development.
Blood, 119 (7).
pp. 1747-1756.
ISSN 0006-4971
doi: https://doi.org/10.1182/blood-2011-09-380709
Jarvis, G. E., Bihan, D., Hamaia, S., Pugh, N., Ghevaert, C. J. G., Pearce, A. C., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Watson, S. P., Ware, J., Rudd, C. E. and Farndale, R. W.
(2012)
A role for adhesion and degranulation-promoting adapter protein in collagen-induced platelet activation mediated via integrin α(2) β(1).
Journal of Thrombosis and Haemostasis, 10 (2).
pp. 268-277.
ISSN 1538-7933
doi: https://doi.org/10.1111/j.1538-7836.2011.04567.x
Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Radhakrishnan, U. P., Lordkipanidzé, M., Egginton, S., Dijkstra, J. M., Jagadeeswaran, P. and Watson, S. P.
(2012)
G6f-like is an ITAM-containing collagen receptor in thrombocytes.
PLoS ONE, 7 (12).
e52622.
ISSN 1932-6203
doi: https://doi.org/10.1371/journal.pone.0052622
Brazón, J., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Mori, J., Sevcik, C., D'suze, G. and Watson, S. P.
(2011)
Tityus discrepans scorpion venom activates platelets through GPVI and a novel Src-dependent signaling pathway.
Platelets, 22 (3).
pp. 165-172.
ISSN 0953-7104
doi: https://doi.org/10.3109/09537104.2010.544343
Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Navarro-Núñez, L., Finney, B. A., Mourão-Sá, D., Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154 and Watson, S. P.
(2010)
CLEC-2 is not required for platelet aggregation at arteriolar shear.
Journal of Thrombosis and Haemostasis, 8 (10).
pp. 2328-2332.
ISSN 1538-7933
doi: https://doi.org/10.1111/j.1538-7836.2010.04006.x
Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154, Mori, J., Eble, J. A., Tomlinson, M. G., Hartwig, J. H., O'Callaghan, C. A., Fütterer, K. and Watson, S. P.
(2010)
CLEC-2 activates Syk through dimerization.
Blood, 115 (14).
pp. 2947-2955.
ISSN 1528-0020
doi: https://doi.org/10.1182/blood-2009-08-237834
Spalton, J. C., Mori, J., Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154, Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Eble, J. A. and Watson, S. P.
(2009)
The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets.
Journal of thrombosis and haemostasis : JTH, 7 (7).
pp. 1192-9.
ISSN 1538-7836
Grygielska, B., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820 and Watson, S. P.
(2009)
Molecular basis of platelet activation by an alphaIIbbeta3-CHAMPS peptide.
Journal of thrombosis and haemostasis : JTH, 7 (2).
pp. 339-46.
ISSN 1538-7836
Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Auger, J. M., McGlade, J., Eble, J. A., Pearce, A. C. and Watson, S. P.
(2008)
Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2.
Journal of thrombosis and haemostasis : JTH, 6 (12).
pp. 2152-9.
ISSN 1538-7836
Riba, R., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Graham, A., Watson, S. P. and Naseem, K. M.
(2008)
Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor gamma chain complex.
Journal of thrombosis and haemostasis : JTH, 6 (6).
pp. 1012-20.
ISSN 1538-7836
Pears, C. J., Thornber, K., Auger, J. M., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Grygielska, B., Protty, M. B., Pearce, A. C. and Watson, S. P.
(2008)
Differential roles of the PKC novel isoforms, PKCδ and PKCε, in mouse and human platelets.
PLoS ONE, 3 (11).
e3793.
ISSN 1932-6203
doi: https://doi.org/10.1371/journal.pone.0003793
Hughan, S. C., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, McCarty, O. J. T., Schweighoffer, E., Soultanova, I., Ware, J., Tybulewicz, V. L. J. and Watson, S. P.
(2007)
GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk.
Arteriosclerosis, thrombosis, and vascular biology, 27 (2).
pp. 422-9.
ISSN 1524-4636
Dhanjal, T. S., Ross, E. A., Auger, J. M., McCarty, O. J. T., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Senis, Y. A., Buckley, C. D. and Watson, S. P.
(2007)
Minimal regulation of platelet activity by PECAM-1.
Platelets, 18 (1).
pp. 56-67.
ISSN 0953-7104
Suzuki-Inoue, K., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Inoue, O., Kaneko, M., Cuyun-Lira, O., Takafuta, T., Watson, S. P. and Ozaki, Y.
(2007)
Involvement of Src kinases and PLCgamma2 in clot retraction.
Thrombosis research, 120 (2).
pp. 251-8.
ISSN 0049-3848
García, A., Senis, Y. A., Antrobus, R., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Dwek, R. A., Watson, S. P. and Zitzmann, N.
(2006)
A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: involvement of G6f, a novel platelet Grb2-binding membrane adapter.
Proteomics, 6 (19).
pp. 5332-43.
ISSN 1615-9853
Book or Report Section
Pollitt, A. Y. ORCID: https://orcid.org/0000-0001-8706-5154, Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820 and Watson, S. P.
(2013)
GPVI and CLEC-2.
In: Michelson, A. D. (ed.)
Platelets. 3rd edition.
Academic Press, Amsterdam, pp. 215-231.
ISBN 9780123878373
doi: https://doi.org/10.1016/B978-0-12-387837-3.00011-0
Conference or Workshop Item
Yu, T. Y., Finney, B. A., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820, Dehghani, H., Claridge, E. and Thomas, S. G.
(2013)
Three dimensional analysis of cardiovascular development in mouse embryos using X-ray microcomputed tomography.
In: Microscopy and Analysis.
Thesis
Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820
(2010)
Comparison of CLEC-2 and GPVI signaling in platelets: the role of adaptor proteins.
PhD thesis, University of Birmingham.
This list was generated on Sun Oct 13 15:36:22 2024 UTC.