A

Adiyaman, R. and McGuffin, L. ORCID: https://orcid.org/0000-0003-4501-4767 (2021) ReFOLD3: refinement of 3D protein models with gradual restraints based on predicted local quality and residue contacts. Nucleic Acids Research, 49 (W1). W589-W596. ISSN 1362-4962 doi: https://doi.org/10.1093/nar/gkab300

Ahmad, F., Mitchell, R., Houben, T., Palo, A., Yasdati, T., Parnell, A., Patel, K., Shiri-Sverdlov, R. and Leake, D. ORCID: https://orcid.org/0000-0002-1742-6134 (2021) Cysteamine decreases low density lipoprotein oxidation, causes regression of atherosclerosis and improves liver and muscle function in LDL receptor deficient mice. JAHA: Journal of the American Heart Association, 10 (18). ISSN 2047-9980 doi: https://doi.org/10.1161/JAHA.120.017524

B

Brackenridge, D. A. and McGuffin, L. J. ORCID: https://orcid.org/0000-0003-4501-4767 (2021) Proteins and their interacting partners: an introduction to protein–ligand binding site prediction methods with a focus on FunFOLD3. In: Cacace, A. M., Hickey, C. M. and Bekes, M. (eds.) Targeted Protein Degradation: Methods and Protocols. Methods in Molecular Biology, 2365. Springer, pp. 43-58. ISBN 9781071616642 doi: https://doi.org/10.1007/978-1-0716-1665-9

Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Hoepel, W., Mitchell, J. L., Jegouic, S. M., Loureiro, S. ORCID: https://orcid.org/0009-0000-8886-6893, Sage, T., Vidarsson, G., Nouta, J., Wuhrer, M., de Taeye, S. W., van Gils, M., Kriek, N., Cooper, N., Jones, I. ORCID: https://orcid.org/0000-0002-7738-2516, den Dunnen, J. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2021) Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a pro-thrombotic stimulus for platelets. Blood, 138 (16). pp. 1481-1489. ISSN 0006-4971 doi: https://doi.org/10.1182/blood.2021011871

C

Cai, H., Sasikumar, P., Little, G., Bihan, D., Hamaia, S. W., Zhou, A., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 and Farndale, R. W. (2021) Identification of HSP47 binding site on native collagen and its implications on the development of HSP47 inhibitors. Biomolecules, 11 (7). 983. ISSN 2218-273X doi: https://doi.org/10.3390/biom11070983

Chamata, Y., Jackson, K. G. ORCID: https://orcid.org/0000-0002-0070-3203, Watson, K. A. ORCID: https://orcid.org/0000-0002-9987-8539 and Jauregi, P. (2021) Whey-derived peptides at the heart of the COVID-19 pandemic. International Journal of Molecular Sciences, 22 (21). 11662. ISSN 1422-0067 doi: https://doi.org/10.3390/ijms222111662

D

Derrick, D. J. A., Wolton, K., Currie, R. A. and Tindall, M. J. (2021) A mathematical model of the role of aggregation in sonic hedgehog signalling. PLoS computational biology, 17 (2). e1008562. ISSN 1553-7358 doi: https://doi.org/10.1371/journal.pcbi.1008562

Dunster, J. ORCID: https://orcid.org/0000-0001-8986-4902, Bye, A. ORCID: https://orcid.org/0000-0002-2061-2253, Kriek, N., Sage, T., Mitchell, J., Kempster, C., Batista, J., KcKinney, H., Thomas, P., Jones, C. ORCID: https://orcid.org/0000-0001-7537-1509, Downes, K., Unsworth, A. and Gibbins, J. ORCID: https://orcid.org/0000-0002-0372-5352 (2021) Multi-parameter phenotyping of platelet reactivity for stratification of human cohorts. Blood Advances, 5 (20). pp. 4017-4030. ISSN 2473-9529 doi: https://doi.org/10.1182/bloodadvances.2020003261

E

Edmunds, N. S. and McGuffin, L. J. ORCID: https://orcid.org/0000-0003-4501-4767 (2021) Computational methods for the elucidation of protein structure and interactions. In: Owens, R. J. (ed.) Methods Molecular Biology: Structural Proteomics. Methods Molecular Biology, 2305. Springer Nature, pp. 23-52. ISBN 9781071614068 doi: https://doi.org/10.1007/978-1-0716-1406-8_2

F

Fernández, D. I. ORCID: https://orcid.org/0000-0002-5055-9019, Provenzale, I., Cheung, H. Y. F., van Groningen, J., Tullemans, B. M. E., Veninga, A., Dunster, J. L. ORCID: https://orcid.org/0000-0001-8986-4902, Honarnejad, S. ORCID: https://orcid.org/0000-0002-4558-501X, van den Hurk, H., Kuijpers, M. J. E. and Heemskerk, J. W. M. (2021) Ultra-high throughput Ca2+ assay in platelets to distinguish ITAM-linked and G-protein coupled receptor activation. iScience, 25 (1). 103718. ISSN 2589-0042 doi: https://doi.org/10.1016/j.isci.2021.103718

Fuller, S. J., Edmunds, N. S., McGuffin, L. J. ORCID: https://orcid.org/0000-0003-4501-4767, Hardyman, M. A., Cull, J. J., Alharbi, H. O., Meijles, D. N., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2021) MAP4K4 expression in cardiomyocytes: multiple isoforms, multiple phosphorylations and interactions with striatins. Biochemical Journal, 478 (11). pp. 2121-2143. ISSN 0264-6021 doi: https://doi.org/10.1042/BCJ20210003

G

Gaspar, R. S., Ferreira, P., Mitchell, J. L., Pula, G. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2021) Platelet-derived extracellular vesicles express NADPH oxidase-1 (Nox-1), generate superoxide and modulate platelet function. Free Radical Biology and Medicine, 165. pp. 395-400. ISSN 0891-5849 doi: https://doi.org/10.1016/j.freeradbiomed.2021.01.051

Gaspar, R. S., Mansilla, S., Vieira, V. A., da Silva, L. B., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352, Castro, L., Trostchansky, A. and de A. Paes, A. M. (2021) The protein disulphide isomerase inhibitor CxxCpep modulates oxidative burst and mitochondrial function in platelets. Free Radical Biology and Medicine, 172. pp. 668-674. ISSN 0891-5849 doi: https://doi.org/10.1016/j.freeradbiomed.2021.07.011

Griffin, B. A. and Lovegrove, J. A. ORCID: https://orcid.org/0000-0001-7633-9455 (2021) Evidence for beneficial associations between isoenergetic macronutrient exchanges and serum non-HDL cholesterol, a measure of all circulating atherogenic, apoB-containing lipoproteins. Journal of Nutrition, 151 (8). pp. 2096-2098. ISSN 1541-6100 doi: https://doi.org/10.1093/jn/nxab127

Griffin, B. A., Mensink, R. P. and Lovegrove, J. A. ORCID: https://orcid.org/0000-0001-7633-9455 (2021) Does variation in serum LDL-cholesterol response to dietary fatty acids help explain the controversy over fat quality and cardiovascular disease risk? Atherosclerosis, 328. pp. 108-113. ISSN 0021-9150 doi: https://doi.org/10.1016/j.atherosclerosis.2021.03.024

H

Holbrook, L.-M., Keeton, S. J., Sasikumar, P., Nock, S., Gelzinis, J., Brunt, E., Ryan, S., Pantos, M. M., Verbetsky, C. A., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 and Kennedy, D. R. (2021) Zafirlukast is a broad-spectrum thiol isomerase inhibitor that inhibits thrombosis without altering bleeding times. British Journal of Pharmacology, 178 (3). pp. 550-563. ISSN 1476-5381 doi: https://doi.org/10.1111/bph.15291

Houben, T., Yadati, T., De Kruijf, R., Gijbels, M. J., Luiken, J., Van Zandvoort, M., Kapsokalyvas, D., Lütjohann, D., Westerterp, M., Plat, J., Leake, D. ORCID: https://orcid.org/0000-0002-1742-6134 and Shiri-Sverdlov, R. (2021) Pro-inflammatory implications of 2-hydroxypropyl-β-cyclodextrin treatment. Frontiers in Immunology, 12. 716357. ISSN 1664-3224 doi: https://doi.org/10.3389/fimmu.2021.716357

J

Jannah, N., Hadjiloucas, S. ORCID: https://orcid.org/0000-0003-2380-6114 and Al-Malki, J. (2021) Arrhythmia detection using multi-lead ECG spectra and Complex Support Vector Machine classifiers. Procedia Computer Science, 194. pp. 69-79. ISSN 1877-0509 doi: https://doi.org/10.1016/j.procs.2021.10.060

K

Kryshtafovych, A. ORCID: https://orcid.org/0000-0001-5066-7178, Moult, J. ORCID: https://orcid.org/0000-0002-3012-2282, Billings, W. M., Della Corte, D. ORCID: https://orcid.org/0000-0002-8884-9724, Fidelis, K. ORCID: https://orcid.org/0000-0002-8061-412X, Kwon, S., Olechnovič, K. ORCID: https://orcid.org/0000-0003-4918-9505, Seok, C. ORCID: https://orcid.org/0000-0002-1419-9888, Venclovas, Č., Won, J., Adiyaman, R. and McGuffin, L. ORCID: https://orcid.org/0000-0003-4501-4767 (2021) Modeling SARS‐CoV2 proteins in the CASP ‐commons experiment. Proteins: Structure, Function, and Bioinformatics, 89 (12). pp. 1987-1996. ISSN 0887-3585 doi: https://doi.org/10.1002/prot.26231

L

Livingstone, K. M., Celis-Morales, C., Navas-Carretero, S., San-Cristobal, R., Forster, H., Woolhead, C., O’Donovan, C. B., Moschonis, G., Manios, Y., Traczyk, I., Gundersen, T. E., Drevon, C. A., Marsaux, C. F. M., Fallaize, R., Macready, A. L. ORCID: https://orcid.org/0000-0003-0368-9336, Daniel, H., Saris, W. H. M., Lovegrove, J. A. ORCID: https://orcid.org/0000-0001-7633-9455, Gibney, M., Gibney, E. R., Walsh, M., Brennan, L., Martinez, J. A. and Mathers, J. C. (2021) Personalised nutrition advice reduces intake of discretionary foods and beverages: findings from the Food4Me randomised controlled trial. International Journal of Behavioral Nutrition and Physical Activity, 18 (1). 70. ISSN 1479-5868 doi: https://doi.org/10.1186/s12966-021-01136-5

M

Markey, O., Vasilopoulou, D., Kliem, K. E. ORCID: https://orcid.org/0000-0002-0058-8225, Fagan, C. C. ORCID: https://orcid.org/0000-0002-2101-8694, Grandison, A. S., Sutton, R., Humphries, D. J., Todd, S. ORCID: https://orcid.org/0000-0002-9981-923X, Jackson, K. G. ORCID: https://orcid.org/0000-0002-0070-3203, Givens, D. I. ORCID: https://orcid.org/0000-0002-6754-6935 and Lovegrove, J. A. ORCID: https://orcid.org/0000-0001-7633-9455 (2021) Postprandial fatty acid profile, but not cardiometabolic risk markers, is modulated by dairy fat manipulation in adults with moderate cardiovascular disease risk: the randomized controlled REplacement of SaturatEd fat in dairy on Total cholesterol (RESET) study. Journal of Nutrition, 151 (7). pp. 1755-1768. ISSN 1541-6100 doi: https://doi.org/10.1093/jn/nxab050

N

Navas-Carretero, S., San-Cristobal, R., Alvarez-Alvarez, I., Celis-Morales, C., Livingstone, K. M., O'Donovan, C. B., Mavrogianni, C., Lambrinou, C. P., Manios, Y., Traczyck, I., Drevon, C. A., Marsaux, C. F. M., Saris, W. H. M., Fallaize, R., Macready, A. L. ORCID: https://orcid.org/0000-0003-0368-9336, Lovegrove, J. A. ORCID: https://orcid.org/0000-0001-7633-9455, Gundersen, T. E., Walsh, M., Brennan, L., Gibney, E. R., Gibney, M., Mathers, J. C. and Martinez, J. A. (2021) Interactions of carbohydrate intake and physical activity with regulatory genes affecting glycaemia: a Food4Me study analysis. Lifestyle Genomics, 14 (3). pp. 63-72. ISSN 2504-3188 doi: https://doi.org/10.1159/000515068

Nock, S. (2021) The dual kinase and scaffold function of Btk downstream of GPVI and CLEC-2 in platelets. PhD thesis, University of Reading. doi: https://doi.org/10.48683/1926.00101688

O

Ojo, O. O. and Leake, D. S. ORCID: https://orcid.org/0000-0002-1742-6134 (2021) Vitamins E and C do not effectively inhibit low density lipoprotein oxidation by ferritin at lysosomal pH. Free Radical Research, 55 (5). pp. 525-534. ISSN 1071-5762 doi: https://doi.org/10.1080/10715762.2021.1964494

R

Rathnayake, K. M., Weech, M. ORCID: https://orcid.org/0000-0003-1738-877X, Lovegrove, J. A. ORCID: https://orcid.org/0000-0001-7633-9455 and Jackson, K. G. ORCID: https://orcid.org/0000-0002-0070-3203 (2021) Glu298Asp (rs1799983) polymorphism influences postprandial vascular reactivity and the insulin response to meals of varying fat composition in postmenopausal women: findings from the randomized, controlled DIVAS-2 study. Journal of Nutrition, 151 (4). pp. 848-856. ISSN 1541-6100 doi: https://doi.org/10.1093/jn/nxaa394

S

Sahli, K. A., Flora, G. D., Sasikumar, P., Maghrabi, A. H., Holbrook, L., AlOuda, S. K., Elgheznawy, A., Sage, T., Stainer, A. R., Adiyaman, R., AboHassan, M., Crescente, M., Kriek, N., Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517, Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Unsworth, A. J., Jones, C. I. ORCID: https://orcid.org/0000-0001-7537-1509, McGuffin, L. J. ORCID: https://orcid.org/0000-0003-4501-4767 and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2021) Structural, functional and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets. Blood, 137 (6). pp. 830-843. ISSN 0006-4971 doi: https://doi.org/10.1182/blood.2019004575

Simoes Gaspar, R. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2021) Thiol isomerases orchestrate thrombosis and haemostasis. Antioxidants & Redox Signaling, 35 (13). ISSN 1523-0864 doi: https://doi.org/10.1089/ars.2021.0086

Simoes Gaspar, R., Sage, T., Little, G., Kriek, N., Pula, G. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2021) Protein disulphide isomerase and NADPH oxidase 1 cooperate to control platelet function and are associated with cardiometabolic disease risk factors. Antioxidants, 10 (3). 497. ISSN 2076-3921 doi: https://doi.org/10.3390/antiox10030497

Simões Gaspar, R. (2021) Investigation of how redox processes regulate platelet function in health and disease. PhD thesis, University of Reading. doi: https://doi.org/10.48683/1926.00107568

Sowa, M. A. (2021) Artificial lipid membranes to study the platelet CLEC-2-podoplanin interaction. PhD thesis, University of Reading. doi: https://doi.org/10.48683/1926.00109189

T

Taylor, K. A. ORCID: https://orcid.org/0000-0002-4599-7727, Little, G. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2021) Mind the gap: connexins and pannexins in platelet function. Platelets, 32 (7). pp. 888-894. ISSN 0953-7104 doi: https://doi.org/10.1080/09537104.2021.1902971

U

Unsworth, A. J., Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Sage, T., Gaspar, R. S., Eaton, N., Drew, C., Stainer, A., Kriek, N., Volberding, P. J., Hutchinson, J. L., Riley, R., Jones, S., Mundell, S. J., Cui, W., Falet, H. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2021) Anti-platelet properties of Pim kinase inhibition is mediated through disruption of thromboxane A2 receptor signalling. Haematologica, 106 (7). ISSN 1592-8721 doi: https://doi.org/10.3324/haematol.2019.223529

V

Vavouraki, N. ORCID: https://orcid.org/0000-0003-2581-4935, Tomkins, J. E. ORCID: https://orcid.org/0000-0003-3010-6634, Kara, E. ORCID: https://orcid.org/0000-0001-5428-6743, Houlden, H., Hardy, J., Tindall, M. J., Lewis, P. A. ORCID: https://orcid.org/0000-0003-4537-0489 and Manzoni, C. (2021) Integrating protein networks and machine learning for disease stratification in the Hereditary Spastic Paraplegias. iScience, 24 (5). 102484. ISSN 2589-0042 doi: https://doi.org/10.1016/j.isci.2021.102484

Vogtschmidt, Y. D., Raben, A., Faber, I., de Wilde, C., Lovegrove, J. A. ORCID: https://orcid.org/0000-0001-7633-9455, Givens, D. I. ORCID: https://orcid.org/0000-0002-6754-6935, Pfeiffer, A. F. H. and Soedamah-Muthu, S. S. (2021) Is protein the forgotten ingredient: effects of higher compared to lower protein diets on cardiometabolic risk factors. A systematic review and meta-analysis of randomised controlled trials. Atherosclerosis, 328. pp. 124-135. ISSN 0021-9150 doi: https://doi.org/10.1016/j.atherosclerosis.2021.05.011