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Jump to: Atherogenic effects of the lysosomal oxidation of low density lipoprotein - Scientific Meeting Costs | Cell and Molecular, animal and human imaging facilities for the Institute for Cardiovascular Metabolic Research | Clinical Research Fellowship - Dr Emre Amirak | Mechanical stimulation of heart cells as a model of heart failure in vitro | Protein sumoylation in platelets: a potential new signalling paradigm in the control of haemostasis and thrombosis | RCUK: Fellowship | Regulation and function of activating transcription factor 3 (ATF3) in cardiac myocytes | Stress-induced post-transcriptional regulation of gene expression by the Exon Junction Complex in Cardiac Mycocytes | Study of the role of gap junctions and connexin hemichannels in the control of platlet function, haemostasis and thrombosis | Study of the role of secreted platelet thiol isomerases in the regulation of platelet function, haemostasis and thrombosis | The Virtual Platelet - a computational model for the complex regulation of platelet function | The Virtual Platelet - the development of a predictive mathematical model for the complex regulation of platelet function | The mechanisms of heart failure: Mechanosensing and maladaptation in cardiac myocytes | The physiological importance and integration of receptor-mediated inhibitory mechanisms in platelets | The physiological importance and integration of receptor-mediated inhibitory mechanisms in platelets in health and disease | The role of BRaf in the heart and cardiac effects vemurafenib, dabrafenib and trametinib, recently licensed cancer therapies that target BRaf and MKK1/2 | The role of thromboxane receptors and Rho mediated signalling in regulation of endothelial cell calcium activated potassium channels and endothelium dependent hyperpolarisation

Number of items: 71.

Atherogenic effects of the lysosomal oxidation of low density lipoprotein - Scientific Meeting Costs

Ahmad, F. and Leake, D. S. (2019) Lysosomal oxidation of LDL alters lysosomal pH, induces senescence and increases secretion of pro-inflammatory cytokines in human macrophages. Journal of Lipid Research, 60. pp. 98-110. ISSN 1539-7262 doi: https://doi.org/10.1194/jlr.M088245

Palmer, C., Peri, F., Neumann, F., Ahmad, F., Leake, D. S. and Pirianov, G. (2018) The synthetic glycolipid-based TLR4 antagonist FP7 negatively regulates in vitro and in vivo haematopoietic and non-haematopoietic vascular TLR4 signalling. Innate Immunity, 24 (7). pp. 411-421. ISSN 1753-4267 doi: https://doi.org/10.1177/1753425918798904

Cell and Molecular, animal and human imaging facilities for the Institute for Cardiovascular Metabolic Research

Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Unsworth, A. J., Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517, Stainer, A. R., Fry, M. J. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2015) Ibrutinib inhibits platelet integrin αIIbβ3 outside-in signaling and thrombus stability but not adhesion to collagen. Arteriosclerosis Thrombosis and Vascular Biology, 35 (11). pp. 2326-2335. ISSN 1524-4636 doi: https://doi.org/10.1161/ATVBAHA.115.306130

Clinical Research Fellowship - Dr Emre Amirak

Tindall, M. J. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2014) Modelling negative feedback networks for activating transcription factor 3 predicts a dominant role for miRNAs in immediate early gene regulation. PLoS Computational Biology, 10 (5). e1003597. ISSN 1553-734X doi: https://doi.org/10.1371/journal.pcbi.1003597

Mechanical stimulation of heart cells as a model of heart failure in vitro

Pierrat, O. A., Paudyal, A., Woodruff, J., Koroleva, O. and Boateng, S. Y. (2017) The exon junction complex senses energetic stress and regulates contractility and cell architecture in cardiac myocytes. Bioscience Reports, 37 (4). BSR20170707. ISSN 0144-8463 doi: https://doi.org/10.1042/BSR20170707

Protein sumoylation in platelets: a potential new signalling paradigm in the control of haemostasis and thrombosis

AlOuda, S. K., Sasikumar, P., AlThunayan, T., Alaajam, F., Khan, S., Sahli, K. A., Abohassan, M. S., Pollitt, A., Jung, S. M. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2023) Role of heat shock protein 47 in platelet glycoprotein VI dimerisation and signaling. Research and Practice in Thrombosis and Haemostasis, 7 (6). 102177. ISSN 2475-0379 doi: https://doi.org/10.1016/j.rpth.2023.102177

Wright, J. R., Jones, S., Parvathy, S., Kaczmarek, L. K., Forsythe, I., Farndale, R. W., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 and Mahaut-Smith, M. P. (2022) The voltage-gated K+ channel Kv1.3 modulates platelet motility and α2β1 integrin-dependent adhesion to collagen. Platelets, 33 (3). pp. 451-461. ISSN 0953-7104 doi: https://doi.org/10.1080/09537104.2021.1942818

Huang, Z., Barker, D., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 and Dash, P. R. (2018) Talin is a substrate for SUMOylation in migrating cancer cells. Experimental Cell Research, 370 (2). pp. 417-425. ISSN 0014-4827 doi: https://doi.org/10.1016/j.yexcr.2018.07.005

Stainer, A., Sasikumar, P., Bye, A. ORCID: https://orcid.org/0000-0002-2061-2253, Unsworth, A., Holbrook, L., Tindall, M., Lovegrove, J. ORCID: https://orcid.org/0000-0001-7633-9455 and Gibbins, J. ORCID: https://orcid.org/0000-0002-0372-5352 (2019) Quercetin and its methylated metabolites possess anti-thrombotic properties that interact with aspirin to enhance its anti-platelet effects. TH Open, 3 (3). e244-e258. ISSN 2512-9465 doi: https://doi.org/10.1055/s-0039-1694028

Flora, G. D., Sahli, K. A., Sasikumar, P., Holbrook, L.-M., Stainer, A. R., Alouda, S. K., Crescente, M., Sage, T., Unsworth, A. J. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2019) Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis. Scientific Reports, 9 (1). 17210. ISSN 2045-2322 doi: https://doi.org/10.1038/s41598-019-53218-x

Holbrook, L.-M., Keeton, S. J., Sasikumar, P., Nock, S., Gelzinis, J., Brunt, E., Ryan, S., Pantos, M. M., Verbetsky, C. A., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 and Kennedy, D. R. (2021) Zafirlukast is a broad-spectrum thiol isomerase inhibitor that inhibits thrombosis without altering bleeding times. British Journal of Pharmacology, 178 (3). pp. 550-563. ISSN 1476-5381 doi: https://doi.org/10.1111/bph.15291

RCUK: Fellowship

Regulation and function of activating transcription factor 3 (ATF3) in cardiac myocytes

Stress-induced post-transcriptional regulation of gene expression by the Exon Junction Complex in Cardiac Mycocytes

Study of the role of gap junctions and connexin hemichannels in the control of platlet function, haemostasis and thrombosis

Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517, Sunagar, K., Gibbins, J. ORCID: https://orcid.org/0000-0002-0372-5352, Jackson, T. N. W., Reeks, T. and Fry, B. G. (2015) Kallikrein enzymes. In: Fry, B. (ed.) Venomous reptiles and their toxins: evolution, pathophysiology and biodiscovery. Oxford University Press, New York, pp. 267-280. ISBN 9780199309399

Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517, Flora, G. D. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2015) Gap junctions and connexin hemichannels in the regulation of haemostasis and thrombosis. Biochemical Society Transactions, 43 (3). pp. 489-494. ISSN 1470-8752 doi: https://doi.org/10.1042/BST20150055

Lewin, M. R., Samuel, S. P., Wexler, D. S., Bickler, P., Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517 and Mensh, B. D. (2014) Early treatment with intranasal neostigmine reduces mortality in a mouse model of Naja naja (Indian Cobra) envenomation. Journal of Tropical Medicine, 2014. 131835. ISSN 1687-9686 doi: https://doi.org/10.1155/2014/131835

Mazet, F., Dunster, J. L., Jones, C. I. ORCID: https://orcid.org/0000-0001-7537-1509, Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517, Tindall, M. J., Fry, M. J. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2015) A high-density immunoblotting methodology for quantification of total protein levels and phosphorylation modifications. Scientific Reports, 5. 16995. ISSN 2045-2322 doi: https://doi.org/10.1038/srep16995

Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517, Sage, T., Rana, R. H., Schenk, M. P., Ali, M. S., Unsworth, A. J., Jones, C. I. ORCID: https://orcid.org/0000-0001-7537-1509, Stainer, A. R., Kriek, N. K., Moraes, L. A. and Gibbins, J. ORCID: https://orcid.org/0000-0002-0372-5352 (2015) EphB2 regulates contact-dependent and independent signalling to control platelet function. Blood, 125 (4). pp. 720-730. ISSN 0006-4971 doi: https://doi.org/10.1182/blood-2014-06-585083

Study of the role of secreted platelet thiol isomerases in the regulation of platelet function, haemostasis and thrombosis

Fuentos, E., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352, Holbrook, L. M. and Palomo, I. (2018) NADPH oxidase 2 (NOX2): a key target of oxidative stress-mediated platelet activation and thrombosis. Trends in Cardiovascular Medicine, 28 (7). pp. 429-434. ISSN 1050-1738 doi: https://doi.org/10.1016/j.tcm.2018.03.001

Simoes Gaspar, R. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2021) Thiol isomerases orchestrate thrombosis and haemostasis. Antioxidants & Redox Signaling, 35 (13). ISSN 1523-0864 doi: https://doi.org/10.1089/ars.2021.0086

Gaspar, R. S., Mansilla, S., Vieira, V. A., da Silva, L. B., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352, Castro, L., Trostchansky, A. and de A. Paes, A. M. (2021) The protein disulphide isomerase inhibitor CxxCpep modulates oxidative burst and mitochondrial function in platelets. Free Radical Biology and Medicine, 172. pp. 668-674. ISSN 0891-5849 doi: https://doi.org/10.1016/j.freeradbiomed.2021.07.011

Simoes Gaspar, R., Sage, T., Little, G., Kriek, N., Pula, G. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2021) Protein disulphide isomerase and NADPH oxidase 1 cooperate to control platelet function and are associated with cardiometabolic disease risk factors. Antioxidants, 10 (3). 497. ISSN 2076-3921 doi: https://doi.org/10.3390/antiox10030497

The Virtual Platelet - a computational model for the complex regulation of platelet function

Dunster, J. L., Mazet, F., Fry, M. J., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 and Tindall, M. J. (2015) Regulation of early steps of GPVI signal transduction by phosphatases: a systems biology approach. PLoS Computational Biology, 11 (11). e1004589. ISSN 1553-734X doi: https://doi.org/10.1371/journal.pcbi.1004589

Bayani, A., Dunster, J. L., Crofts, J. J. and Nelson, M. R. (2020) Mechanisms and points of control in the spread of inflammation: a mathematical investigation. Bulletin of Mathematical Biology, 82 (4). 45. ISSN 1522-9602 doi: https://doi.org/10.1007/s11538-020-00709-y

The Virtual Platelet - the development of a predictive mathematical model for the complex regulation of platelet function

Unsworth, A. J., Kriek, N., Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Naran, K., Sage, T., Flora, G. D. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2017) PPARγ agonists negatively regulate αIIbβ3 integrin outside-in signalling and platelet function through upregulation of protein kinase A activity. Journal of Thrombosis and Haemostasis, 15 (2). pp. 356-369. ISSN 1538-7933 doi: https://doi.org/10.1111/jth.13578

The mechanisms of heart failure: Mechanosensing and maladaptation in cardiac myocytes

The physiological importance and integration of receptor-mediated inhibitory mechanisms in platelets

Jones, C. I. ORCID: https://orcid.org/0000-0001-7537-1509, Sage, T., Moraes, L. A., Vaiyapuri, S. ORCID: https://orcid.org/0000-0002-6006-6517, Hussain, U., Tucker, K. L., Barrett, N. E. ORCID: https://orcid.org/0000-0001-9123-1100 and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2014) Platelet endothelial cell adhesion molecule-1 inhibits platelet response to thrombin and von Willebrand factor by regulating the internalization of glycoprotein Ib via AKT/glycogen synthase kinase-3/dynamin and integrin αIIbβ3. Arteriosclerosis Thrombosis and Vascular Biology, 34 (9). pp. 1968-1976. ISSN 1079-5642 doi: https://doi.org/10.1161/ATVBAHA.114.304097

Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Unsworth, A. J. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2016) Platelet signaling: a complex interplay between inhibitory and activatory networks. Journal of Thrombosis and Haemostasis, 14 (5). pp. 918-930. ISSN 1538-7933 doi: https://doi.org/10.1111/jth.13302

Unsworth, A. J., Flora, G. D., Sasikumar, P., Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Sage, T., Kriek, N., Crescente, M. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2017) RXR ligands negatively regulate thrombosis and hemostasis. Arteriosclerosis Thrombosis and Vascular Biology, 37 (5). pp. 812-822. ISSN 1524-4636 doi: https://doi.org/10.1161/ATVBAHA.117.309207

The physiological importance and integration of receptor-mediated inhibitory mechanisms in platelets in health and disease

Unsworth, A. J., Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Sage, T., Gaspar, R. S., Eaton, N., Drew, C., Stainer, A., Kriek, N., Volberding, P. J., Hutchinson, J. L., Riley, R., Jones, S., Mundell, S. J., Cui, W., Falet, H. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2021) Anti-platelet properties of Pim kinase inhibition is mediated through disruption of thromboxane A2 receptor signalling. Haematologica, 106 (7). ISSN 1592-8721 doi: https://doi.org/10.3324/haematol.2019.223529

Gaspar, R. S., Ferreira, P., Mitchell, J. L., Pula, G. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2021) Platelet-derived extracellular vesicles express NADPH oxidase-1 (Nox-1), generate superoxide and modulate platelet function. Free Radical Biology and Medicine, 165. pp. 395-400. ISSN 0891-5849 doi: https://doi.org/10.1016/j.freeradbiomed.2021.01.051

Dunster, J., Mitchell, J., Mohammed, Y., Taylor, K. ORCID: https://orcid.org/0000-0002-4599-7727, Gibbins, J. ORCID: https://orcid.org/0000-0002-0372-5352 and Jones, C. ORCID: https://orcid.org/0000-0001-7537-1509 (2021) Kinetx: a combined flow cytometry assay and analysis software framework to quantitatively measure and categorize platelet activation in real-time. Journal of Visualized Experiments, 176. e62947. ISSN 1940-087X doi: https://doi.org/10.3791/62947

Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 and Mahaut-Smith, M. P. (2020) Ca2+ waves coordinate purinergic receptor–evoked integrin activation and polarization. Science Signaling, 13 (615). eaav7354. ISSN 1937-9145 doi: https://doi.org/10.1126/scisignal.aav7354

Macwan, A. S., Boknas, N., Ntzouni, M. P., Ramstrom, S., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352, Faxalv, L. and Lindahl, T. L. (2019) Gradient-dependent inhibition of stimulatory signaling from platelet G protein-coupled receptors. Haematologica, 104 (7). pp. 1482-1492. ISSN 1592-8721 doi: https://doi.org/10.3324/haematol.2018.205815

Unsworth, A. J., Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Kriek, N., Sage, T., Osborne, A. A., Donaghy, D. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2019) Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction. Platelets, 30 (6). pp. 762-772. ISSN 0953-7104 doi: https://doi.org/10.1080/09537104.2018.1514107

Stefanini, L., Lee, R. H., Paul, D. S., O'Shaughnessy, E. C., Ghalloussi, D., Jones, C. I. ORCID: https://orcid.org/0000-0001-7537-1509, Boulaftali, Y., Poe, K. O., Piatt, R., Kechele, D. O., Caron, K. M., Hahn, K. M., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 and Bergmeier, W. (2018) Functional redundancy between RAP1 isoforms in murine platelet production and function. Blood, 132 (18). pp. 1951-1962. ISSN 0006-4971 doi: https://doi.org/10.1182/blood-2018-03-838714

Belyaev, A. V., Dunster, J. L., Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352, Panteleev, M. A. and Volpert, V. (2018) Modelling thrombosis in silico: frontiers, challenges, unresolved problems and milestones. Physics of Life Reviews, 26-27. pp. 57-95. ISSN 1571-0645 doi: https://doi.org/10.1016/j.plrev.2018.02.005

Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253 and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2018) Move along, nothing to see here: Btk inhibitors stop platelets sticking to plaques. Journal of Thrombosis and Haemostasis, 16 (8). pp. 1461-1463. ISSN 1538-7933 doi: https://doi.org/10.1111/jth.14201

Molica, F., Figueroa, X. F., Kwak, B. R., Isakson, B. E. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2018) Connexins and pannexins in vascular function and disease. International Journal of Molecular Sciences, 19 (6). 1663. ISSN 1422-0067 doi: https://doi.org/10.3390/ijms19061663

Unsworth, A. J., Flora, G. D. and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2018) Non-genomic effects of nuclear receptors: insights from the anucleate platelet. Cardiovascular Research, 114 (5). pp. 645-655. ISSN 0008-6363 doi: https://doi.org/10.1093/cvr/cvy044

Bye, A. P. ORCID: https://orcid.org/0000-0002-2061-2253, Unsworth, A. J., Desborough, M. J., Hildyard, C. A. T., Appleby, N., Bruce, D., Kriek, N., Nock, S. H., Sage, T., Hughes, C. E. ORCID: https://orcid.org/0000-0002-9790-5820 and Gibbins, J. M. ORCID: https://orcid.org/0000-0002-0372-5352 (2017) Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib. Blood Advances, 1 (26). pp. 2610-2623. ISSN 2473-9529 doi: https://doi.org/10.1182/bloodadvances.2017011999

The role of BRaf in the heart and cardiac effects vemurafenib, dabrafenib and trametinib, recently licensed cancer therapies that target BRaf and MKK1/2

Alharbi, H. O., Hardyman, M. A., Cull, J. J., Markou, T., Cooper, S. T. E., Glennon, P. E., Fuller, S. J., Sugden, P. H. and Clerk, A. ORCID: https://orcid.org/0000-0002-5658-0708 (2022) Cardiomyocyte BRAF is a key signalling intermediate in cardiac hypertrophy in mice. Clinical Science, 136 (22). pp. 1661-1681. ISSN 0143-5221 doi: https://doi.org/10.1042/CS20220607

The role of thromboxane receptors and Rho mediated signalling in regulation of endothelial cell calcium activated potassium channels and endothelium dependent hyperpolarisation

Barrese, V., Cidad, P., Yueng, S. Y., Lopez-Lopez, J. R., McNeish, A., Ohya, S., Perez-Garcia, M. T. and Greenwood, I. A. (2017) Proliferative role of Kv11 channels in murine arteries. Frontiers in Physiology, 8. 500. ISSN 1664-042X doi: https://doi.org/10.3389/fphys.2017.00500

Onetti, Y., Dantas, A. Y., Perez, B., McNeish, A. J., Vila, E. and Jimenez-Altyayo, F. (2017) Peroxynitrate formed during a transient episode of brain ischemia increases endothelium-derived hyperpolarization-type dilations in thromboxane/prostaglandin receptor stimulated rat cerebral arteries. Acta Physiologica, 220 (1). pp. 150-166. ISSN 1748-1716 doi: https://doi.org/10.1111/apha.12809

Roux, B. T., Bauer, C. C., McNeish, A. J., Ward, S. G. and Cottrell, G. S. ORCID: https://orcid.org/0000-0001-9098-7627 (2017) The role of ubiquitination and hepatocyte growth factor-regulated tyrosine kinase substrate in the degradation of the adrenomedullin type I receptor. Scientific Reports, 7 (1). p. 12389. ISSN 2045-2322 doi: https://doi.org/10.1038/s41598-017-12585-z

Gauthier, K. M., Campbell, W. B. and McNeish, A. J. (2014) Regulation of KCa2.3 andendothelium-dependent hyperpolarization (EDH) in the rat middle cerebral artery: the role of lipoxygenase metabolites and isoprostanes. PeerJ, 2. e414. ISSN 2167-8359 doi: https://doi.org/10.7717/peerj.414

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