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Detecting non-multiplicative genotype relative risks from transmissions of parental alleles to affected children

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Ayres, K. L. and Curnow, R. N. (2005) Detecting non-multiplicative genotype relative risks from transmissions of parental alleles to affected children. Journal of Human Genetics, 50 (1). pp. 46-48. ISSN 1435-232X

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To link to this article DOI: 10.1007/s10038-004-0217-5

Abstract/Summary

The differential transmission of alleles from parents to affected children indicates that the locus under investigation is either directly involved in the occurrence of the disease or that there are allelic associations with other loci that are directly involved. Conditional logistic regression applied to a diallelic locus leads to a test with two degrees of freedom. The power of a single degree of freedom test to detect non-multiplicative allelic effects is discussed here.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences
ID Code:10264
Uncontrolled Keywords:genotype relative risks, conditional logistic regression, allelic, transmission, CANDIDATE-GENE ASSOCIATION, DESIGN
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