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Reintroduction of the 2G12 epitope in an HIV-1 clade C gp120

Chen, H. Y., Xu, X. D., Bishop, A. and Jones, I. M. (2005) Reintroduction of the 2G12 epitope in an HIV-1 clade C gp120. Aids, 19 (8). pp. 833-835. ISSN 0269-9370

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Abstract/Summary

Many clade C isolates of HIV-1 do not react with monoclonal antibody (MAb) 2G12, a broad-ranging human neutralizing MAb that recognizes high mannose carbohydrate groups attached to glycoprotein gp120. We reintroduced a partial and complete 2G12 epitope into a clade C background, HIV-1(CN54), and examined the antibody reactivity of the resulting recombinant molecules. Two glycosylation sites recovered 2G12 binding completely, but some binding was evident after the reintroduction of a single glycosylation site at Asn295.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences
ID Code:10293
Uncontrolled Keywords:IMMUNODEFICIENCY-VIRUS TYPE-1, HUMAN MONOCLONAL-ANTIBODY, NEUTRALIZING, ANTI-HIV-1 ANTIBODY, VACCINE DESIGN, OLIGOSACCHARIDES, GLYCOPROTEIN, REACTIVITY, PROTEIN, CLUSTER

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