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Comparison of the bacterial Enhancin-like proteins from Yersinia and Bacillus spp. with a baculovirus Enhancin

Galloway, C. S., Wang, P., Winstanley, D. and Jones, I. M. (2005) Comparison of the bacterial Enhancin-like proteins from Yersinia and Bacillus spp. with a baculovirus Enhancin. Journal of Invertebrate Pathology, 90 (2). pp. 134-137. ISSN 0022-2011

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To link to this article DOI: 10.1016/j.jip.2005.06.008

Abstract/Summary

Enhancins are a class of metalloproteases found in some baculoviruses that enhance viral infection by degrading the peritrophic, membrane (PM) of the insect midgut. However, sequencing has revealed enhancin-like genes with 24-25% homology to viral enhancins, in the genomes of Yersinia pestis and Bacillus anthracis. AcMNPV does not encode enhancin therefore recombinant AcMNPV budded viruses (BVs) and polyhedra inclusion bodies (PIBs) were generated expressing the bacterial Enhancins. Bacterial Enhancins were found to be cytotoxic when compared to viral enhancin, however, larval bioassays suggested that the bacterial Enhancins did not enhance infection in the same way as viral Enhancin. This suggests that the bacterial Enhancins may have evolved a distinct biochemical function. (c) 2005 Elsevier Inc. All rights reserved.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences
ID Code:10322
Uncontrolled Keywords:enhancin, baculovirus, Yersinia spp., Bacillus spp., protein function, NUCLEAR POLYHEDROSIS-VIRUS, GRANULOSIS-VIRUS, GENOME SEQUENCE, NUCLEOPOLYHEDROVIRUS ENHANCIN, SIGNAL PEPTIDES, PREDICTION, ANTHRACIS, SITES

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