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New challenges in the study of the mammalian tachykinins

Page, N. M. (2005) New challenges in the study of the mammalian tachykinins. Peptides, 26 (8). pp. 1356-1368. ISSN 0196-9781

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To link to this item DOI: 10.1016/j.peptides.2005.03.030

Abstract/Summary

There is an expanding repertoire of mammalian tachykinins produced by a variety of tachykinin genes, gene splicing events and peptide processing. Novel tachykinin-binding molecules/receptors are proposed, but only, three tachykinin receptors are identified with certainty. The question remains - do more tachykinin receptors exist or is there just the need to reappraise Our understanding of the known receptors? The tachykinin NK1 receptor, the preferred receptor for both substance P and the peripheral SP-like endokinins, exists in several tissue-specific conformations and isoforms and may provide some clues. This review addresses recent advances in this exciting field and raises challenging new concepts. (c) 2005 Elsevier Inc. All rights reserved.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences
ID Code:10368
Uncontrolled Keywords:endokinin, hemokinin tachykinin, neurokinin, peptide, receptor, long, short isoform, substance P, tachykinin NK1 receptor, virokinin, SUBSTANCE-P RECEPTOR, PORCINE SPINAL-CORD, HUMAN NEUROKININ-3 RECEPTOR, NK1 RECEPTOR, NEUROPEPTIDE-GAMMA, FUNCTIONAL EXPRESSION, MESSENGER-RNAS, BINDING-SITES, HIGH-AFFINITY, PHARMACOLOGICAL PROFILE

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