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Intra-individual variation of serum prostate specific antigen levels in men with benign prostate biopsies

Boddy, J. L., Dev, S., Pike, D. J. and Malone, P. R. (2004) Intra-individual variation of serum prostate specific antigen levels in men with benign prostate biopsies. Bju International, 93 (6). pp. 735-738. ISSN 1464-4096

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To link to this item DOI: 10.1111/j.1464-410X.2004.04717.x

Abstract/Summary

To determine the intra-individual (physiological) variation of prostate-specific antigen (PSA) measurements in men after a benign prostatic biopsy. Sixty-four men were prospectively assessed, all of whom had a benign prostatic biopsy within the preceding 13 months. The degree of intra-individual variability was established by calculating the coefficient of variation on four PSA levels obtained from each patient weekly over a month. Six patients were subsequently diagnosed with prostate cancer and their data are presented separately. In the remaining 58 patients the median (range) individual mean PSA value was 6.3 (0.5-34.1) ng/mL. The median (range) coefficient of variation within the group was 9.5 (2.4-76.1)%. There was a clear linear relationship between mean PSA level and the standard deviation. In 48 of the 63 patients analysed, the coefficient of variation for serum PSA values in the group as a whole was greater than the variation claimed for the assay technique. The significance of the linear relationship between PSA and the standard deviation is discussed, with particular reference to those men who had a benign prostate biopsy.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences
ID Code:10437
Uncontrolled Keywords:PSA, intra-individual, variation, benign biopsy, BIOLOGICAL VARIATION, NEEDLE-BIOPSY, CYSTOSCOPY, POPULATION, PREDICTORS, CANCER

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