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CCL3, acting via the chemokine receptor CCR5, leads to independent activation of Janus kinase 2 (JAK2) and G(i) proteins

Mueller, A. and Strange, P. G. (2004) CCL3, acting via the chemokine receptor CCR5, leads to independent activation of Janus kinase 2 (JAK2) and G(i) proteins. FEBS Letters, 570 (1-3). pp. 126-132. ISSN 0014-5793

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To link to this item DOI: 10.1016/j.feblet.2004.04.100

Abstract/Summary

The interaction of the chemokine receptor, CCR5, expressed in recombinant cells, with different G proteins was investigated and CCR5 was found to interact with G(i), G(o) and G(q) species. Interaction with Gi leads to G protein activation, whereas G. does not seem to be activated. Additionally, CCR5 activation also leads to phosphorylation of Janus kinase 2 (JAK2). Activation of JAK2 is independent of Gi or Gq activation. Gi protein activation was not prevented by inhibition of JAK, showing that heterotrimeric G protein activation and activation of the JAK/signal transducer and activator of transcription (STAT) pathway are independent of each other. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences
ID Code:10557
Uncontrolled Keywords:CCR5, JAK2, G protein, [S-35]GTP gamma S binding assay, calcium ion, release, T-CELLS, IMMUNODEFICIENCY-VIRUS, JAK/STAT PATHWAY, RANTES, DIMERIZATION, STATS, SIGNAL, IDENTIFICATION, STIMULATION, MIP-1-ALPHA

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