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Hemokinins and endokinins

Page, N. M. (2004) Hemokinins and endokinins. Cellular and Molecular Life Sciences, 61 (13). pp. 1652-1663. ISSN 1420-682X

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To link to this item DOI: 10.1007/s00018-004-4035-x

Abstract/Summary

The mammalian tachykinins are a family of peptides that, until recently, has included substance P (SP), neurokinin A and neurokinin B. Since, the discovery of a third preprotachykinin gene (TAC4), the number of tachykinins has more than doubled to reveal several species-divergent peptides. This group includes hemokinin-1 (HK-1) in mouse and rat, endokinin-1 (EK-1) in rabbit, and EKA, EKB, human HK-1 (hHK-1) and hHK(4-11) in humans. Each exhibits a remarkable selectivity and potency for the tachykinin NK1 receptor similar to SP. Their peripheral expression has led to the proposal that they are the endogenous peripheral SP-like endocrine/paracrine agonists where SP is not expressed. Moreover, their strong cross-reactivity with a specific SP antibody leads us to question many of the proposed locations and roles of SP in the periphery. Additionally, three orphan tachykinin gene-related peptides are identified on TAC4, in rabbit, EK-2 and in humans, EKC and EKD.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences
ID Code:10570
Uncontrolled Keywords:endokinin, hemokinin, tachykinin, neurokinin, peptide, TAC4, SUBSTANCE-P PRECURSOR, PORCINE SPINAL-CORD, TACHYKININ NK1 RECEPTOR, MAMMALIAN TACHYKININ, NEUROKININ-B, PHARMACOLOGICAL PROFILE, GAMMA-PREPROTACHYKININ, HYPOTHALAMIC TISSUE, SALIVARY SECRETION, NEUROMEDIN-K

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