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Characterisation of an amphioxus Fringe gene and the evolution of the vertebrate segmentation clock

Mazet, F. and Shimeld, S. M. (2003) Characterisation of an amphioxus Fringe gene and the evolution of the vertebrate segmentation clock. Development Genes and Evolution, 213 (10). pp. 505-509. ISSN 0949-944X

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To link to this item DOI: 10.1007/s00427-003-0351-7

Abstract/Summary

In mouse and chick embryos, cyclic expression of lunatic fringe has an important role in the regulation of mesoderm segmentation. We have isolated a Fringe gene from the protochordate amphioxus. Amphioxus is the closest living relative of the vertebrates, and has mesoderm that is definitively segmented in a manner that is similar to, and probably homologous with, that of vertebrates. AmphiFringe is placed basal to vertebrate Fringe genes in molecular phylogenetic analyses, indicating that the duplications that formed radical-, manic- and lunatic fringe are specific to the vertebrate lineage. AmphiFringe expression was detected in the anterior neural plate of early neurulae, where it resolved into a series of segmental patches by the mid-neurulae stage. No AmphiFringe transcripts were detected in the mesoderm. Based on these observations, we propose a model depicting a successive recruitment of Fringe in the maintenance then regulation of segmentation during vertebrate evolution.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences
ID Code:10819
Uncontrolled Keywords:amphioxus, fringe, somite, evolution, segmentation, LUNATIC-FRINGE, SOMITE SEGMENTATION, NOTCH, EXPRESSION, GLYCOSYLTRANSFERASE, SOMITOGENESIS, ZEBRAFISH, SUGGESTS, FAMILY

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