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Synthesis of labelled dihydroartemisinic acid

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Brown, G.D. and Sy, L.K. (2004) Synthesis of labelled dihydroartemisinic acid. Tetrahedron, 60 (5). pp. 1125-1138. ISSN 0040-4020

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To link to this item DOI: 10.1016/j.tet.2003.11.069

Abstract/Summary

[15-(CH3)-C-13-H-2]-Dihydroartemisinic acid (2a), [15-(CH3)-H-2]-dihydroartemisinic acid (2b) and [15-(CH3)-C-13]-dihydroartemisinic acid (2c) have been obtained in good yield and high isotopic enrichment by a reconstructive synthesis from artemisinin. These labelled compounds were designed to be used in biosynthetic experiments to determine the origins of artemisinin and other sesquiterpene natural products from Artemisia annua. (C) 2003 Elsevier Ltd. All rights reserved.

Item Type:Article
Refereed:Yes
Divisions:Life Sciences > School of Chemistry, Food and Pharmacy > Department of Chemistry
ID Code:11062
Uncontrolled Keywords:terpenes and terpenoids, labelling, isotope effects, NMR, ARTEMISIA-ANNUA L, ARTEANNUIN-B, SPONTANEOUS AUTOXIDATION, BIOSYNTHESIS, DEOXYARTEANNUIN, SESQUITERPENES, ANTIMALARIAL, PLANTS
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