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Intra-ovarian roles of activins and inhibins

Knight, P. G., Satchell, L. and Glister, C. (2012) Intra-ovarian roles of activins and inhibins. Molecular and Cellular Endocrinology, 359 (1-2). pp. 53-65. ISSN 0303-7207

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To link to this article DOI: 10.1016/j.mce.2011.04.024

Abstract/Summary

Granulosa cells are the main ovarian source of inhibins, activins and activin-binding protein (follistatin) while germ (oogonia, oocytes) and somatic (theca, granulosa, luteal) cells express activin receptors, signaling components and inhibin co-receptor (betaglycan). Activins are implicated in various intra-ovarian roles including germ cell survival and primordial follicle assembly; follicle growth from preantral to mid-antral stages; suppression of thecal androgen production; promotion of granulosa cell proliferation, FSHR and CYP19A1 expression; enhancement of oocyte developmental competence; retardation of follicle luteinization and/or atresia and involvement in luteolysis. Inhibins (primarily inhibin A) are produced in greatest amounts by preovulatory follicles (and corpus luteum in primates) and suppress FSH secretion through endocrine negative feedback. Together with follistatin, inhibins act locally to oppose auto-/paracrine activin (and BMP) signaling thus modulating many of the above processes. The balance between activin-inhibin shifts during follicle development with activin signalling prevailing at earlier stages but declining as inhibin and betaglycan expression rise.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences > Biomedical Sciences
ID Code:23000
Uncontrolled Keywords:Inhibin; Activin; Follistatin; Ovary; Follicle; Corpus luteum
Publisher:Elsevier

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