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Features for detection of Parkinson's disease tremor from local field potentials of the subthalamic nucleus

Bakstein, E., Warwick, K., Burgess, J. G., Stavdahl, O. and Aziz, T. (2010) Features for detection of Parkinson's disease tremor from local field potentials of the subthalamic nucleus. In: Cybernetic Intelligent Systems (CIS), 2010 IEEE 9th International Conference on. IEEE, London, pp. 1-6. ISBN 9781424490233

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To link to this article DOI: 10.1109/UKRICIS.2010.5898092

Abstract/Summary

Deep Brain Stimulation (DBS) is a treatment routinely used to alleviate the symptoms of Parkinson's disease (PD). In this type of treatment, electrical pulses are applied through electrodes implanted into the basal ganglia of the patient. As the symptoms are not permanent in most patients, it is desirable to develop an on-demand stimulator, applying pulses only when onset of the symptoms is detected. This study evaluates a feature set created for the detection of tremor - a cardinal symptom of PD. The designed feature set was based on standard signal features and researched properties of the electrical signals recorded from subthalamic nucleus (STN) within the basal ganglia, which together included temporal, spectral, statistical, autocorrelation and fractal properties. The most characterized tremor related features were selected using statistical testing and backward algorithms then used for classification on unseen patient signals. The spectral features were among the most efficient at detecting tremor, notably spectral bands 3.5-5.5 Hz and 0-1 Hz proved to be highly significant. The classification results for determination of tremor achieved 94% sensitivity with specificity equaling one.

Item Type:Book or Report Section
Refereed:Yes
Divisions:Faculty of Science > School of Systems Engineering
ID Code:26558
Publisher:IEEE

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