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Control of DNA conformation using 3'-S-phosphorothiolate-modified linkages

Buckingham, J., Sabbagh, G., Brazier, J., Fisher, J. and Cosstick, R. (2005) Control of DNA conformation using 3'-S-phosphorothiolate-modified linkages. Nucleosides, Nucleotides & Nucleic Acids, 24 (5-7). pp. 491-495. ISSN 1532-2335

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To link to this article DOI: 10.1081/NCN-200061776

Abstract/Summary

An in-depth study into the incorporation of multiple 3'-S-phosphorothiolate modifications into oligodeoxynucleotides (ODNs) and their subsequent effect on ODN/DNA and ODN/RNA duplex stability. 3'-S-Phosphorothiolate linkages increase the stability of ODN/RNA duplexes and decrease the stability of ODN/DNA duplexes.

Item Type:Article
Refereed:Yes
Divisions:No Reading authors. Back catalogue items
ID Code:27308
Publisher:Taylor & Francis

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