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A reappraisal of blood clotting response tests for anticoagulant resistance and a proposal for a standardised BCR test methodology

Prescott, C. V., (2003) A reappraisal of blood clotting response tests for anticoagulant resistance and a proposal for a standardised BCR test methodology. RRAC Technical Monograph. 2003. Technical Report. Rodenticide Resistance Action Committee of CropLife International pp21.

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Official URL: http://www.rrac.info/releases_01.htm

Abstract/Summary

Blood clotting response (BCR) resistance tests are available for a number of anticoagulant rodenticides. However, during the development of these tests many of the test parameters have been changed, making meaningful comparisons between results difficult. It was recognised that a standard methodology was urgently required for future BCR resistance tests and, accordingly, this document presents a reappraisal of published tests, and proposes a standard protocol for future use (see Appendix). The protocol can be used to provide information on the incidence and degree of resistance in a particular rodent population; to provide a simple comparison of resistance factors between active ingredients, thus giving clear information about cross-resistance for any given strain; and to provide comparisons of susceptibility or resistance between different populations. The methodology has a sound statistical basis in being based on the ED50 response, and requires many fewer animals than the resistance tests in current use. Most importantly, tests can be used to give a clear indication of the likely practical impact of the resistance on field efficacy. The present study was commissioned and funded by the Rodenticide Resistance Action Committee (RRAC) of CropLife International.

Item Type:Report (Technical Report)
Divisions:Faculty of Life Sciences > School of Biological Sciences > Environmental Biology
ID Code:27541
Publisher:Rodenticide Resistance Action Committee of CropLife International

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