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Assessment of inter-examiner agreement and variability in the manual classification of auditory brainstem response

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Naves, K. F. P., Pereira, A. A., Nasuto, S. J., Russo, I. P. C. and Andrade, A. O. (2012) Assessment of inter-examiner agreement and variability in the manual classification of auditory brainstem response. BioMedical Engineering OnLine, 11. 86. ISSN 1475-925X

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To link to this item DOI: 10.1186/1475-925X-11-86

Abstract/Summary

Abstract Background: The analysis of the Auditory Brainstem Response (ABR) is of fundamental importance to the investigation of the auditory system behaviour, though its interpretation has a subjective nature because of the manual process employed in its study and the clinical experience required for its analysis. When analysing the ABR, clinicians are often interested in the identification of ABR signal components referred to as Jewett waves. In particular, the detection and study of the time when these waves occur (i.e., the wave latency) is a practical tool for the diagnosis of disorders affecting the auditory system. Significant differences in inter-examiner results may lead to completely distinct clinical interpretations of the state of the auditory system. In this context, the aim of this research was to evaluate the inter-examiner agreement and variability in the manual classification of ABR. Methods: A total of 160 ABR data samples were collected, for four different stimulus intensity (80dBHL, 60dBHL, 40dBHL and 20dBHL), from 10 normal-hearing subjects (5 men and 5 women, from 20 to 52 years). Four examiners with expertise in the manual classification of ABR components participated in the study. The Bland-Altman statistical method was employed for the assessment of inter-examiner agreement and variability. The mean, standard deviation and error for the bias, which is the difference between examiners’ annotations, were estimated for each pair of examiners. Scatter plots and histograms were employed for data visualization and analysis. Results: In most comparisons the differences between examiner’s annotations were below 0.1 ms, which is clinically acceptable. In four cases, it was found a large error and standard deviation (>0.1 ms) that indicate the presence of outliers and thus, discrepancies between examiners. Conclusions: Our results quantify the inter-examiner agreement and variability of the manual analysis of ABR data, and they also allows for the determination of different patterns of manual ABR analysis.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences > Department of Bio-Engineering
ID Code:32271
Uncontrolled Keywords:Auditory brainstem response, ABR classification, Inter-examiner variability
Additional Information:The full text of this article is freely available via PMC using the link supplied in Related URLs Cite this article as: Naves et al.: Assessment of inter-examiner agreement and variability in the manual classification of auditory brainstem response. BioMedical Engineering OnLine 2012 11:86.
Publisher:Biomed Central

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