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The hemodynamic impulse response to a single neural event

Martindale, J., Mayhew, J., Berwick, J., Jones, M., Martin, C., Johnston, D., Redgrave, P. and Zheng, Y. (2003) The hemodynamic impulse response to a single neural event. Journal of Cerebral Blood Flow and Metabolism, 23. pp. 546-555. ISSN 1559-7016

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To link to this item DOI: 10.1097/01.WCB.0000058871.46954.2B

Abstract/Summary

This article investigates the relation between stimulus-evoked neural activity and cerebral hemodynamics. Specifically, the hypothesis is tested that hemodynamic responses can be modeled as a linear convolution of experimentally obtained measures of neural activity with a suitable hemodynamic impulse response function. To obtain a range of neural and hemodynamic responses, rat whisker pad was stimulated using brief (less than or equal to2 seconds) electrical stimuli consisting of single pulses (0.3 millisecond, 1.2 mA) combined both at different frequencies and in a paired-pulse design. Hemodynamic responses were measured using concurrent optical imaging spectroscopy and laser Doppler flowmetry, whereas neural responses were assessed through current source density analysis of multielectrode recordings from a single barrel. General linear modeling was used to deconvolve the hemodynamic impulse response to a single "neural event" from the hemodynamic and neural responses to stimulation. The model provided an excellent fit to the empirical data. The implications of these results for modeling schemes and for physiologic systems coupling neural and hemodynamic activity are discussed.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences > Department of Bio-Engineering
ID Code:33486
Uncontrolled Keywords:Current source density; Optical imaging spectroscopy; Hemodynamics; Impulse response; General linear modeling; Rat
Publisher:Nature

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