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Fluorinated ionic surfactant microemulsions in hydrofluorocarbon 134a (HFC 134a)

Patel, N., Marlow, M. and Lawrence, M. J. (2003) Fluorinated ionic surfactant microemulsions in hydrofluorocarbon 134a (HFC 134a). Journal of Colloid and Interface Science, 258 (2). pp. 354-362. ISSN 0021-9797

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To link to this item DOI: 10.1016/S0021-9797(02)00071-1

Abstract/Summary

The factors influencing the formation of water-in-134a-propellant microemulsions using the fluorinated ionic surfactants ammonium perfluorooctanoate, ammonium perfluoroheptanoate, and sodium perfluorooctanoate has been determined. None of the fluorinated ionic surfactants could be used to prepare clear, one-phase systems when used as sole surfactant, but they could be when combined with a short-chain fluoro- or hydrocarbon alcohol in surfactant:cosurfactant weight-mixing ratios (K(m)) in the range 1:2 to 2:1. When hydrocarbon alcohols were used this clear region extended over a wide range of compositions and was confirmed by means of photon correlation spectroscopy (PCS) to contain microemulsion droplets in the propellant-rich part of the phase diagram. PCS studies performed in the presence of the water-soluble drug terbutaline sulfate showed that it was possible to solubilize the drug within water-in-propellant microemulsion droplets. These studies confirm for the first time that it is possible to prepare water-in-propellant 134a microemulsions using fluorinated ionic surfactants and to solubilize water-soluble drugs within these systems.

Item Type:Article
Refereed:Yes
Divisions:No Reading authors. Back catalogue items
ID Code:37506
Publisher:Elsevier

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