Accessibility navigation


Coupling between gamma-band power and cerebral blood volume during recurrent acute neocortical seizures

Harris, S., Ma, H., Zhao, M., Boorman, L., Zheng, Y., Kennerley, A., Bruyns-Haylett, M., Overton, P. G., Berwick, J. and Schwartz, T. H. (2014) Coupling between gamma-band power and cerebral blood volume during recurrent acute neocortical seizures. NeuroImage, 97. pp. 62-70. ISSN 1053-8119

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1016/j.neuroimage.2014.04.014

Abstract/Summary

Characterization of neural and hemodynamic biomarkers of epileptic activity that can be measured using noninvasive techniques is fundamental to the accurate identification of the epileptogenic zone (EZ) in the clinical setting. Recently, oscillations at gamma-band frequencies and above (N30 Hz) have been suggested to provide valuable localizing information of the EZ and track cortical activation associated with epileptogenic processes. Although a tight coupling between gamma-band activity and hemodynamic-based signals has been consistently demonstrated in non-pathological conditions, very little is known about whether such a relationship is maintained in epilepsy and the laminar etiology of these signals. Confirmation of this relationship may elucidate the underpinnings of perfusion-based signals in epilepsy and the potential value of localizing the EZ using hemodynamic correlates of pathological rhythms. Here, we use concurrent multi-depth electrophysiology and 2- dimensional optical imaging spectroscopy to examine the coupling between multi-band neural activity and cerebral blood volume (CBV) during recurrent acute focal neocortical seizures in the urethane-anesthetized rat. We show a powerful correlation between gamma-band power (25–90 Hz) and CBV across cortical laminae, in particular layer 5, and a close association between gamma measures and multi-unit activity (MUA). Our findings provide insights into the laminar electrophysiological basis of perfusion-based imaging signals in the epileptic state and may have implications for further research using non-invasive multi-modal techniques to localize epileptogenic tissue

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences > Department of Bio-Engineering
ID Code:39828
Uncontrolled Keywords:Neurovascular coupling Gamma 4-AP Focal epilepsy
Publisher:Elsevier

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation