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Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation

Ura, S., Pollitt, A. Y., Veltman, D. M., Morrice, N. A., Machesky, L. M. and Insall, R. H. (2012) Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation. Current Biology, 22 (7). pp. 553-561. ISSN 0960-9822

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To link to this item DOI: 10.1016/j.cub.2012.02.020

Abstract/Summary

Regulated dephosphorylation of a fraction of the cellular SCAR pool is a key step in SCAR activation during pseudopod growth. Phosphorylation increases autoinhibition of the intact complex. Dephosphorylation weakens this interaction and facilitates SCAR activation but also destabilizes the protein. We show that SCAR is specifically dephosphorylated in pseudopods, increasing activation by Rac and lipids and supporting positive feedback of pseudopod growth.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences > Biomedical Sciences
ID Code:44793
Publisher:Elsevier

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