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Role of FTO in adipocyte development and function: recent insights

Merkestein, M. and Sellayah, D. (2015) Role of FTO in adipocyte development and function: recent insights. International Journal of Endocrinology, 2015. 521381. ISSN 1687-8337

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To link to this item DOI: 10.1155/2015/521381

Abstract/Summary

In 2007, FTO was identified as the first genome-wide association study (GWAS) gene associated with obesity in humans. Since then, various animal models have served to establish the mechanistic basis behind this association. Many earlier studies focussed on FTO’s effects on food intake via central mechanisms. Emerging evidence, however, implicates adipose tissue development and function in the causal relationship between perturbations in FTO expression and obesity. The purpose of this mini review is to shed light on these new studies of FTO function in adipose tissue and present a clearer picture of its impact on obesity susceptibility.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences > Biomedical Sciences
ID Code:49318
Publisher:Hindawi

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