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A glimpse of the ERM proteins

Ponuwei, G. A. (2016) A glimpse of the ERM proteins. Journal of Biomedical Science, 23 (1). 35. ISSN 1423-0127

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To link to this item DOI: 10.1186/s12929-016-0246-3

Abstract/Summary

In all eukaryotes, the plasma membrane is critically important as it maintains the architectural integrity of the cell. Proper anchorage and interaction between the plasma membrane and the cytoskeleton is critical for normal cellular processes. The ERM (ezrin-radixin-moesin) proteins are a class of highly homologous proteins involved in linking the plasma membrane to the cortical actin cytoskeleton. This review takes a succinct look at the biology of the ERM proteins including their structure and function. Current reports on their regulation that leads to activation and deactivation was examined before taking a look at the different interacting partners. Finally, emerging roles of each of the ERM family members in cancer was highlighted.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences > Biomedical Sciences
ID Code:62833
Uncontrolled Keywords:Ezrin Radixin Moesin Plasma membrane Phospholipids Cancer
Publisher:Springer

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