Accessibility navigation


Ubiquitin sets the timer: impacts on aging and longevity

Kevei, E. and Hoppe, T. (2014) Ubiquitin sets the timer: impacts on aging and longevity. Nature structural & molecular biology, 21 (4). pp. 290-292. ISSN 1545-9985

[img]
Preview
Text - Accepted Version
· Please see our End User Agreement before downloading.

277kB

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1038/nsmb.2806

Abstract/Summary

Protein homeostasis is essential for cellular function, organismal growth and viability. Damaged and aggregated proteins are turned over by two major proteolytic routes of the cellular quality-control pathways: the ubiquitin-proteasome system and autophagy. For both these pathways, ubiquitination provides the recognition signal for substrate selection. This Commentary discusses how ubiquitin-dependent proteolytic pathways are coordinated with stress- and aging-induced signals.

Item Type:Article
Refereed:No
Divisions:Faculty of Life Sciences > School of Biological Sciences > Biomedical Sciences
ID Code:65858
Publisher:Nature Publishing Group

Downloads

Downloads per month over past year

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation