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Platelet responses to agonists in a cohort of highly characterised platelet donors are consistent over time

Garner, S. F., Furnell, A., Kahan, B. C., Jones, C. I., Attwood, A., Harrison, P., Kelly, A. M., Goodall, A. H., Cardigan, R. and Ouwehand, W. H. (2017) Platelet responses to agonists in a cohort of highly characterised platelet donors are consistent over time. Vox Sanguinis, 112 (1). pp. 18-24. ISSN 1423-0410

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To link to this item DOI: 10.1111/vox.12468

Abstract/Summary

Background and Objectives Platelet function shows significant inheritance that is at least partially genetically controlled. There is also evidence that the platelet response is stable over time, but there are few studies that have assessed consistency of platelet function over months and years. We aimed to measure platelet function in platelet donors over time in individuals selected from a cohort of 956 donors whose platelet function had been previously characterised. Materials and Methods Platelet function was assessed by flow cytometry, measuring fibrinogen binding and P-selectin expression after stimulation with either cross-linked collagen-related peptide or adenosine 50-diphosphate. Eighty-nine donors from the Cambridge Platelet Function Cohort whose platelet responses were initially within the lower or upper decile of reactivity were retested between 4 months and five and a half years later. Results There was moderate-to-high correlation between the initial and repeat platelet function results for all assays (P ≤ 0.007, r2 0.2961–0.7625); furthermore, the range of results observed in the initial low and high responder groups remained significantly different at the time of the second test (P ≤ 0.0005). Conclusion Platelet function remains consistent over time. This implies that this potential influence on quality of donated platelet concentrates will remain essentially constant for a given donor.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences > Biomedical Sciences
ID Code:68657
Publisher:Wiley

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