Accessibility navigation


Gene regulatory network inference

Babtie, A. C., Stumpf, M. P. H. and Thorne, T. (2019) Gene regulatory network inference. In: Voit, E. (ed.) Reference Module in Biomedical Sciences. Elsevier.

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1016/B978-0-12-801238-3.11346-7

Abstract/Summary

Transcriptomic data quantifying gene expression states for single cells or cell populations at a genomic level is now readily available. Changes in transcriptional state during cell development and function are governed by gene regulatory networks, comprising a collection of genes and regulatory interactions between these genes (or gene products). Network inference algorithms aim to infer functional interactions between genes from experimentally observed expression profiles, and identify the structure of the underlying regulatory networks. Here we describe popular classes of network inference algorithms, highlighting their respective strengths and weaknesses, along with some general challenges faced by these methods. Analyzing inferred network structures can provide insight into the genes, transcriptional changes, and regulatory interactions that play key roles in biological and disease-related processes of interest.

Item Type:Book or Report Section
Refereed:No
Divisions:Faculty of Science > School of Mathematical, Physical and Computational Sciences > Department of Computer Science
ID Code:87798
Publisher:Elsevier

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation