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The sequential analysis of repeated binary responses: a score test for the case of three time points

Sooriyarachchi, M.R., Whitehead, J., Whitehead, A. and Bolland, K. (2006) The sequential analysis of repeated binary responses: a score test for the case of three time points. Statistics in Medicine, 25 (13). pp. 2196-2214. ISSN 0277-6715

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To link to this article DOI: 10.1002/sim.2339

Abstract/Summary

In this paper a robust method is developed for the analysis of data consisting of repeated binary observations taken at up to three fixed time points on each subject. The primary objective is to compare outcomes at the last time point, using earlier observations to predict this for subjects with incomplete records. A score test is derived. The method is developed for application to sequential clinical trials, as at interim analyses there will be many incomplete records occurring in non-informative patterns. Motivation for the methodology comes from experience with clinical trials in stroke and head injury, and data from one such trial is used to illustrate the approach. Extensions to more than three time points and to allow for stratification are discussed. Copyright © 2005 John Wiley & Sons, Ltd.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Science > School of Mathematical and Physical Sciences > Department of Mathematics and Statistics > Applied Statistics
ID Code:9456
Uncontrolled Keywords:binary data , longitudinal data , repeated observations , score test , sequential clinical trial

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