CD8+ T-cells mediate immunopathology in tick-borne encephalitisRuzek, D., Salat, J., Palus, M., Gritsun, T. S., Gould, E. A., Dykova, I., Skallova, A., Jelinek, J., Kopecky, J. and Grubhoffer, L. (2009) CD8+ T-cells mediate immunopathology in tick-borne encephalitis. Virology, 384 (1). pp. 1-6. ISSN 0042-6822 Full text not archived in this repository. It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1016/j.virol.2008.11.023 Abstract/SummaryEpidemics of tick-borne encephalitis involving thousands of humans occur annually in the forested regions of Europe and Asia. Despite the importance of this disease, the underlying basis for the development of encephalitis remains undefined. Here, we prove the key role of CD8(+) T-cells in the immunopathology of tick-borne encephalitis, as demonstrated by prolonged survival of SCID or CD8(-/-) mice, following infection, when compared with immunocompetent mice or mice with adoptively transferred CD8(+) T-cells. The results imply that tick-borne encephalitis is an immunopathological disease and that the inflammatory reaction significantly contributes to the fatal outcome of the infection. (C) 2008 Elsevier Inc. All rights reserved.
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