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Interaction of pesticides with p-glycoprotein and other ABC proteins: A survey of the possible importance to insecticide, herbicide and fungicide resistance

Buss, D. S. and Callaghan, A. (2008) Interaction of pesticides with p-glycoprotein and other ABC proteins: A survey of the possible importance to insecticide, herbicide and fungicide resistance. Pesticide Biochemistry and Physiology, 90 (3). pp. 141-153. ISSN 0048-3575

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To link to this article DOI: 10.1016/j.pestbp.2007.12.001

Abstract/Summary

P-glycoproteins (p-gps) are ubiquitous membrane proteins from the ABC (ATP-binding cassette) family. They have been found in many animals, bacteria, plants and fungi and are extremely important in regulating a wide range of xenobiotics including pesticides. P-gps have been linked to xenobiotic resistance, most famously in resistance to cancer drug treatments. Their wide substrate range has led to what is known as "multidrug resistance", where resistance developed to one type of xenobiotic gives resistance to a different classes of xenobiotic. P-gps are a major contributor to drug resistance in mammalian tumours and infections of protozoan parasites such as Plasmodium and Leishmania. There is a growing body of literature suggesting that p-gps, and other ABC proteins, are important in regulating pesticide toxicity and represent potential control failure through the development of pesticide resistance, in both agricultural and medical pests. At the same time, aspects of their biochemistry offer new hope in pest control, in particular in furthering our understanding of toxicity and offering insights into how we can improve control without recourse to new chemical discovery. (c) 2008 Elsevier Inc. All rights reserved.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences
ID Code:9760
Uncontrolled Keywords:Culex pipiens, p-glycoprotein, resistance, insecticide, herbicide, fungicide, BLOOD-BRAIN-BARRIER, BINDING CASSETTE TRANSPORTER, GLUTATHIONE-S-TRANSFERASES, PEST HELICOVERPA-ARMIGERA, HIV PROTEASE, INHIBITORS, BREAST-CANCER CELLS, MULTIDRUG-RESISTANCE, MDR1 GENE, DRUG-RESISTANCE, SACCHAROMYCES-CEREVISIAE

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