Accessibility navigation


Origin and evolution of flavivirus 5'UTRs and panhandles: trans-terminal duplications?

Gritsun, T. S. and Gould, E. A. (2007) Origin and evolution of flavivirus 5'UTRs and panhandles: trans-terminal duplications? Virology, 366 (1). pp. 8-15. ISSN 0042-6822

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1093/icb/icm026

Abstract/Summary

Flavivirus replication is mediated by interactions between complementary ssRNA sequences of the 5'- and 3'-termini that form dsRNA cyclisation stems or panhandles, varying in length, sequence and specific location in the mosquito-borne, tick-borne, non-vectored and non-classified flaviviruses. In this manuscript we manually aligned the flavivirus 5'UTRs and adjacent capsid genes and revealed significantly more homology than has hitherto been identified. Analysis of the alignments revealed that the panhandles represent evolutionary remnants of a long cyclisation domain that probably emerged through duplication of one of the UTR termini.

Item Type:Article
Refereed:Yes
Divisions:Faculty of Life Sciences > School of Biological Sciences
ID Code:9998
Uncontrolled Keywords:5' Untranslated Regions/*genetics, Base Sequence, *Evolution, Molecular, Flavivirus/*genetics, Models, Molecular, Molecular Sequence Data, Nucleic Acid Conformation, RNA, Viral/chemistry/genetics, Sequence Alignment, *Virus Replication

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation