Detecting non-multiplicative genotype relative risks from transmissions of parental alleles to affected childrenAyres, K. L. and Curnow, R. N. (2005) Detecting non-multiplicative genotype relative risks from transmissions of parental alleles to affected children. Journal of Human Genetics, 50 (1). pp. 46-48. ISSN 1435-232X Full text not archived in this repository. It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1007/s10038-004-0217-5 Abstract/SummaryThe differential transmission of alleles from parents to affected children indicates that the locus under investigation is either directly involved in the occurrence of the disease or that there are allelic associations with other loci that are directly involved. Conditional logistic regression applied to a diallelic locus leads to a test with two degrees of freedom. The power of a single degree of freedom test to detect non-multiplicative allelic effects is discussed here.
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