Dispersal of NK homeobox gene clusters in amphioxus and humansLuke, G. N., Castro, L. F. C., McLay, K., Bird, C., Coulson, A. and Holland, P. W. H. (2003) Dispersal of NK homeobox gene clusters in amphioxus and humans. Proceedings of the National Academy of Sciences of the United States of America, 100 (9). pp. 5292-5295. ISSN 0027-8424 Full text not archived in this repository. It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing. To link to this item DOI: 10.1073/pnas.0836141100 Abstract/SummaryThe Drosophila melanogaster genome has six physically clustered NK-related homeobox genes in just 180 kb. Here we show that the NK homeobox gene cluster was an ancient feature of bilaterian animal genomes, but has been secondarily split in chordate ancestry. The NK homeobox gene clusters of amphioxus and vertebrates are each split and dispersed at two equivalent intergenic positions. From the ancestral NK gene cluster, only the Tlx-Lbx and NK3-NK4 linkages have been retained in chordates. This evolutionary pattern is in marked contrast to the Hox and ParaHox gene clusters, which are compact in amphioxus and vertebrates, but have been disrupted in Drosophila.
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