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Chapter Five - The function, biogenesis and regulation of the electron transport chains in Campylobacter jejuni: new insights into the bioenergetics of a major food-borne pathogen

Taylor, A. J. ORCID: https://orcid.org/0000-0003-1006-1205 and Kelly, D. J. (2019) Chapter Five - The function, biogenesis and regulation of the electron transport chains in Campylobacter jejuni: new insights into the bioenergetics of a major food-borne pathogen. In: Poole, R. K. (ed.) Advances in Microbial Physiology. Adv Microb Physiol, London, pp. 239-329. ISBN 9780128177136

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To link to this item DOI: 10.1016/BS.AMPBS.2019.02.003

Abstract/Summary

Campylobacter jejuni is a zoonotic Epsilonproteobacterium that grows in the gastrointestinal tract of birds and mammals, and is the most frequent cause of food-borne bacterial gastroenteritis worldwide. As an oxygen-sensitive microaerophile, C. jejuni has to survive high environmental oxygen tensions, adapt to oxygen limitation in the host intestine and resist host oxidative attack. Despite its small genome size, C. jejuni is a versatile and metabolically active pathogen, with a complex and highly branched set of respiratory chains allowing the use of a wide range of electron donors and alternative electron acceptors in addition to oxygen, including fumarate, nitrate, nitrite, tetrathionate and N- or S-oxides. Several novel enzymes participate in these electron transport chains, including a tungsten containing formate dehydrogenase, a Complex I that uses flavodoxin and not NADH, a periplasmic facing fumarate reductase and a cytochrome c tetrathionate reductase. This review presents an updated description of the composition and bioenergetics of these various respiratory chains as they are currently understood, including recent work that gives new insights into energy conservation during electron transport to various alternative electron acceptors. The regulation of synthesis and assembly of the electron transport chains is also discussed. A deeper appreciation of the unique features of the respiratory systems of C. jejuni may be helpful in informing strategies to control this important pathogen.

Item Type:Book or Report Section
Refereed:Yes
Divisions:No Reading authors. Back catalogue items
ID Code:110825
Uncontrolled Keywords:Aidan J Taylor, Bacterial Proteins / genetics*, Bacterial Proteins / metabolism*, Bacterial*, Biological, Campylobacter jejuni / enzymology, Campylobacter jejuni / genetics, Campylobacter jejuni / metabolism*, Carbon / metabolism, David J Kelly, Electron Transport, Energy Metabolism*, Foodborne Diseases / microbiology, Gene Expression Regulation, MEDLINE, Models, NCBI, NIH, NLM, National Center for Biotechnology Information, National Institutes of Health, National Library of Medicine, Non-U.S. Gov't, Oxidation-Reduction, Oxygen / metabolism, PubMed Abstract, Research Support, Review, doi:10.1016/bs.ampbs.2019.02.003, pmid:31126532
Publisher:Adv Microb Physiol

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