Lessons to learn from tumor-educated platelets

Roweth, H. ORCID: https://orcid.org/0000-0002-1100-8409 and Battinelli, E. (2021) Lessons to learn from tumor-educated platelets. Blood, 137 (23). pp. 3174-3180. ISSN 0006-4971 doi: 10.1182/blood.2019003976

Abstract/Summary

Platelets have long been known to play important roles beyond hemostasis and thrombosis. Now recognized as a bona fide mediator of malignant disease, platelets influence various aspects of cancer progression, most notably tumor cell metastasis. Interestingly, platelets isolated from cancer patients often display distinct RNA and protein profiles, with no clear alterations in hemostatic activity. This phenotypically distinct population, termed tumor-educated platelets, now receive significant attention for their potential use as a readily available liquid biopsy for early cancer detection. Although the mechanisms underpinning platelet education are still being defined, direct uptake and storage of tumor-derived factors, signal-dependent changes in platelet RNA processing, and differential platelet production by tumor-educated megakaryocytes are the most prominent scenarios. This article aims to cover the various modalities of platelet education by tumors, in addition to assessing their diagnostic potential.

Item Type	Article
URI	https://centaur.reading.ac.uk/id/eprint/127727
Identification Number/DOI	10.1182/blood.2019003976
Refereed	Yes
Divisions	No Reading authors. Back catalogue items
Publisher	American Society of Hematology
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