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Adaptive designs for Phase I dose-finding studies

Zhou, Y. (2010) Adaptive designs for Phase I dose-finding studies. Fundamental & Clinical Pharmacology, 24 (2). pp. 129-138. ISSN 0767-3981

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To link to this item DOI: 10.1111/j.1472-8206.2009.00746.x


Improving methodology for Phase I dose-finding studies is currently of great interest in pharmaceutical and medical research. This article discusses the current atmosphere and attitude towards adaptive designs and focuses on the influence of Bayesian approaches.

Item Type:Article
Divisions:Science > School of Mathematical, Physical and Computational Sciences > Department of Mathematics and Statistics > Applied Statistics
ID Code:17763
Uncontrolled Keywords:adaptive designs; Bayesian approaches; dose-finding studies continual reassessment method; i/ii clinical-trials; Bayesian decision procedures; healthy-volunteers; down designs; escalation; agent; toxicity; efficacy; outcomes

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