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Complex history of a chromosomal paralogy region: insights from amphioxus aromatic amino acid hydroxylase genes and insulin-related genes

Patton, S.J., Luke, G. and Holland, P.W. (1998) Complex history of a chromosomal paralogy region: insights from amphioxus aromatic amino acid hydroxylase genes and insulin-related genes. Molecular Biology and Evolution, 15 (11). pp. 1373-1380. ISSN 1537-1719

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Aromatic amino acid hydroxylase (AAAH) genes and insulin-like genes form part of an extensive paralogy region shared by human chromosomes 11 and 12, thought to have arisen by tetraploidy in early vertebrate evolution. Cloning of a complementary DNA (cDNA) for an amphioxus (Branchiostoma floridae) hydroxylase gene (AmphiPAH) allowed us to investigate the ancestry of the human chromosome 11/12 paralogy region. Molecular phylogenetic evidence reveals that AmphiPAH is orthologous to vertebrate phenylalanine (PAH) genes; the implication is that all three vertebrate AAAH genes arose early in metazoan evolution, predating vertebrates. In contrast, our phylogenetic analysis of amphioxus and vertebrate insulin-related gene sequences is consistent with duplication of these genes during early chordate ancestry. The conclusion is that two tightly linked gene families on human chromosomes 11 and 12 were not duplicated coincidentally. We rationalize this paradox by invoking gene loss in the AAAH gene family and conclude that paralogous genes shared by paralogous chromosomes need not have identical evolutionary histories.

Item Type:Article
Divisions:Life Sciences > School of Biological Sciences > Biomedical Sciences
ID Code:23832
Uncontrolled Keywords:Amino Acid Sequence Animals Base Sequence Caenorhabditis elegans/genetics Cattle Chickens Chordata, Nonvertebrate/genetics Chromosome Mapping/methods Cloning, Molecular DNA, Complementary/genetics Drosophila melanogaster *Evolution, Molecular Fishes Gene Duplication Humans Insulin-Like Growth Factor I/*genetics Insulin-Like Growth Factor II/*genetics Mice Molecular Sequence Data Multigene Family/genetics Neuropeptides/*genetics Phenylalanine Hydroxylase/*genetics Phylogeny Quail Rabbits Rats Sequence Homology, Nucleic Acid Tryptophan Hydroxylase/genetics Tyrosine 3-Monooxygenase/genetics Xenopus laevis
Additional Information:Patton, S J Luke, G N Holland, P W Comparative Study Research Support, Non-U.S. Gov't United States Molecular biology and evolution Mol Biol Evol. 1998 Nov;15(11):1373-80.
Publisher:Oxford University Press

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