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Spatio-temporal dependencies in functional connectivity in rodent cortical cultures

Spencer, M. C., Downes, J. H., Xydas, D., Hammond, M. W., Becerra, V. M., Whalley, B. J., Warwick, K. and Nasuto, S. (2011) Spatio-temporal dependencies in functional connectivity in rodent cortical cultures. Paladyn, 3 (3). pp. 156-163. ISSN 2081-4836

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To link to this item DOI: 10.2478/s13230-012-0002-7


Models of functional connectivity in cortical cultures on multi-electrodes arrays may aid in understanding how cognitive pathways form and improve techniques that aim to interface with neuronal systems. To enable research on such models, this study uses both data- and model-driven approaches to determine what dependencies are present in and between functional connectivity networks derived from bursts of extracellularly recorded activity. Properties of excitation in bursts were analysed using correlative techniques to assess the degree of linear dependence and then two parallel techniques were used to assess functional connectivity. Three models presenting increasing levels of spatio-temporal dependency were used to capture the dynamics of individual functional connections and their consistencies were verified using surrogate data. By comparing network-wide properties between model generated networks and functional networks from data, complex interdependencies were revealed. This indicates the persistent co-activation of neuronal pathways in spontaneous bursts, as can be found in whole brain structures.

Item Type:Article
Divisions:Life Sciences > School of Biological Sciences > Department of Bio-Engineering
Interdisciplinary Research Centres (IDRCs) > Centre for Integrative Neuroscience and Neurodynamics (CINN)
ID Code:27148
Publisher:SP Versita
Publisher Statement:The final publication is available at


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