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A model of the dynamic relationship between blood flow and volume changes during brain activation

Kong, Y., Zheng, Y. ORCID:, Johnston, D., Martindale, J., Jones, M., Billings, S. and Mayhew, J. (2004) A model of the dynamic relationship between blood flow and volume changes during brain activation. Journal of Cerebral Blood Flow and Metabolism, 24 (12). pp. 1382-1392. ISSN 1559-7016

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To link to this item DOI: 10.1097/01.WCB.0000141500.74439.53


The temporal relationship between changes in cerebral blood flow (CBF) and cerebral blood volume (CBV) is important in the biophysical modeling and interpretation of the hemodynamic response to activation, particularly in the context of magnetic resonance imaging and the blood oxygen level-dependent signal. Grubb et al. (1974) measured the steady state relationship between changes in CBV and CBF after hypercapnic challenge. The relationship CBV proportional to CBFPhi has been used extensively in the literature. Two similar models, the Balloon (Buxton et al., 1998) and the Windkessel (Mandeville et al., 1999), have been proposed to describe the temporal dynamics of changes in CBV with respect to changes in CBF. In this study, a dynamic model extending the Windkessel model by incorporating delayed compliance is presented. The extended model is better able to capture the dynamics of CBV changes after changes in CBF, particularly in the return-to-baseline stages of the response.

Item Type:Article
Divisions:Life Sciences > School of Biological Sciences > Department of Bio-Engineering
ID Code:33485
Uncontrolled Keywords:Dynamic modeling; Cerebral blood flow; Cerebral blood volume; Balloon; Windkessel; Delayed compliance

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