Accessibility navigation

Solution calorimetry as a tool for investigating drug interaction with intestinal fluid

Arnot, L.F., Minet, A., Patel, N. ORCID:, Royall, P.G. and Forbes, B. (2004) Solution calorimetry as a tool for investigating drug interaction with intestinal fluid. Thermochimica Acta, 419 (1-2). pp. 259-266. ISSN 0040-6031

Full text not archived in this repository.

It is advisable to refer to the publisher's version if you intend to cite from this work. See Guidance on citing.

To link to this item DOI: 10.1016/j.tca.2004.02.017


Solution calorimetry offers a reproducible technique for measuring the enthalpy of solution (ΔsolH) of a solute dissolving into a solvent. The ΔsolH of two solutes, propranolol HCl and mannitol were determined in simulated intestinal fluid (SIF) solutions designed to model the fed and fasted states within the gut, and in Hanks’ balanced salt solution (HBSS) of varying pH. The bile salt and lipid within the SIF solutions formed mixed micelles. Both solutes exhibited endothermic reactions in all solvents. The ΔsolH for propranolol HCl in the SIF solutions differed from those in the HBSS and was lower in the fed state than the fasted state SIF solution, revealing an interaction between propranolol and the micellar phase in both SIF solutions. In contrast, for mannitol the ΔsolH was constant in all solutions indicating minimal interaction between mannitol and the micellar phases of the SIF solutions. In this study, solution calorimetry proved to be a simple method for measuring the enthalpy associated with the dissolution of model drugs in complex biological media such as SIF solutions. In addition, the derived power–time curves allowed the time taken for the powdered solutes to form solutions to be estimated.

Item Type:Article
Divisions:No Reading authors. Back catalogue items
ID Code:37517

University Staff: Request a correction | Centaur Editors: Update this record

Page navigation