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Estrogen and thyroid hormone receptor interactions: physiological flexibility by molecular specificity

Vasudevan, N. ORCID:, Ogawa, S. and Pfaff, D. (2002) Estrogen and thyroid hormone receptor interactions: physiological flexibility by molecular specificity. Physiol Rev, 82 (4). pp. 923-44. ISSN 0031-9333 (Print)

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To link to this item DOI: 10.1152/physrev.00014.2002


The influence of thyroid hormone on estrogen actions has been demonstrated both in vivo and in vitro. In transient transfection assays, the effects of liganded thyroid hormone receptors (TR) on transcriptional facilitation by estrogens bound to estrogen receptors (ER) display specificity according to the following: 1) ER isoform, 2) TR isoform, 3) the promoter through which transcriptional facilitation occurs, and 4) cell type. Some of these molecular phenomena may be related to thyroid hormone signaling of seasonal limitations upon reproduction. The various combinations of these molecular interactions provide multiple and flexible opportunities for relations between two major hormonal systems important for neuroendocrine feedbacks and reproductive behaviors.

Item Type:Article
Divisions:No Reading authors. Back catalogue items
ID Code:58922
Uncontrolled Keywords:Animals Estrogens/pharmacology/physiology Female Humans Male Receptors, Estrogen/chemistry/genetics/*physiology Receptors, Thyroid Hormone/chemistry/genetics/*physiology Sexual Behavior, Animal/drug effects Thyroid Hormones/pharmacology/physiology Transcription, Genetic

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