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Discovery of novel 1,2,4-triazolo-1,2,4-triazines with thiomethylpyridine hinge binders as potent c-Met kinase inhibitors

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Dadashpour, S., Kucukkilinc, T. T., Ayazgok, B., Hosseinimehr, S. J., Chippindale, A. ORCID: https://orcid.org/0000-0002-5918-8701, Foroumadi, A. and Irannejad, H. (2019) Discovery of novel 1,2,4-triazolo-1,2,4-triazines with thiomethylpyridine hinge binders as potent c-Met kinase inhibitors. Future Medicinal Chemistry, 11 (10). pp. 1119-1136. ISSN 1756-8927

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To link to this item DOI: 10.4155/fmc-2018-0412

Abstract/Summary

Mesenchymal-epithelial transition factor HGF/c-Met overactivation is involved in diverse human cancers. Herein, we report the synthesis and biological evaluation of thiomethylpyridine-linked triazolotriazines as c-Met kinase inhibitors.

Item Type:Article
Refereed:Yes
Divisions:Interdisciplinary centres and themes > Chemical Analysis Facility (CAF)
ID Code:82834
Publisher:Future Science Group
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